Effects of benzoic acid and its analogues on insulin and glucagon secretion in sheep
The effects of benzoic acid and its analogues on insulin and glucagon secretion were investigated in conscious sheep. Intravenous injections of benzoic acid increased plasma insulin and glucagon concentrations in a dose-dependent manner between 39–1250 μmol/kg, with ED 50s for increasing both hormon...
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| Veröffentlicht in: | European journal of pharmacology 1995-07, Vol.280 (2), p.149-154 |
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| container_title | European journal of pharmacology |
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| creator | Mineo, Hitoshi Ohdate, Tatsuya Fukumura, Kouichi Katayama, Toyohiro Onaga, Takenori Kato, Seiyu Yanaihara, Noboru |
| description | The effects of benzoic acid and its analogues on insulin and glucagon secretion were investigated in conscious sheep. Intravenous injections of benzoic acid increased plasma insulin and glucagon concentrations in a dose-dependent manner between 39–1250 μmol/kg, with ED
50s for increasing both hormones of about 625 μmol/kg. Various derivatives of benzoic acid (625 μmol/kg) were administered and structure-activity relationships were examined. A single carboxylic group was essential for stimulating insulin and glucagon secretion, since both hormone responses were abolished with compounds in which the carboxylic group was replaced by sulfonic or phosphoric groups, or in which another carboxylic element was introduced (phthalic acids). Most of the compounds which introduced other elements (amino and hydroxy groups, and halogens) onto the benzene ring had an altered stimulating activity. Thus the pancreatic endocrine system can recognize the chemical structure of benzoic acid and its derivatives in detail and induce insulin and glucagon secretion in sheep. |
| doi_str_mv | 10.1016/0014-2999(95)00192-N |
| format | Article |
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50s for increasing both hormones of about 625 μmol/kg. Various derivatives of benzoic acid (625 μmol/kg) were administered and structure-activity relationships were examined. A single carboxylic group was essential for stimulating insulin and glucagon secretion, since both hormone responses were abolished with compounds in which the carboxylic group was replaced by sulfonic or phosphoric groups, or in which another carboxylic element was introduced (phthalic acids). Most of the compounds which introduced other elements (amino and hydroxy groups, and halogens) onto the benzene ring had an altered stimulating activity. Thus the pancreatic endocrine system can recognize the chemical structure of benzoic acid and its derivatives in detail and induce insulin and glucagon secretion in sheep.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(95)00192-N</identifier><identifier>PMID: 7589179</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Benzoates - administration & dosage ; Benzoates - chemistry ; Benzoates - pharmacology ; Benzoic acid ; Biological and medical sciences ; Blood Glucose - metabolism ; Dose-Response Relationship, Drug ; Endocrine pancreas ; Glucagon ; Glucagon - blood ; Glucagon - metabolism ; Injections, Intravenous ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin Secretion ; Islets of Langerhans - drug effects ; Islets of Langerhans - metabolism ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Ruminant ; Sheep ; Structure-Activity Relationship</subject><ispartof>European journal of pharmacology, 1995-07, Vol.280 (2), p.149-154</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-681482d831b33afdaf5ed108efeed0b8eab4d4a1a0e5fd760654408637ba30833</citedby><cites>FETCH-LOGICAL-c417t-681482d831b33afdaf5ed108efeed0b8eab4d4a1a0e5fd760654408637ba30833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(95)00192-N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3584094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7589179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mineo, Hitoshi</creatorcontrib><creatorcontrib>Ohdate, Tatsuya</creatorcontrib><creatorcontrib>Fukumura, Kouichi</creatorcontrib><creatorcontrib>Katayama, Toyohiro</creatorcontrib><creatorcontrib>Onaga, Takenori</creatorcontrib><creatorcontrib>Kato, Seiyu</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><title>Effects of benzoic acid and its analogues on insulin and glucagon secretion in sheep</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effects of benzoic acid and its analogues on insulin and glucagon secretion were investigated in conscious sheep. Intravenous injections of benzoic acid increased plasma insulin and glucagon concentrations in a dose-dependent manner between 39–1250 μmol/kg, with ED
50s for increasing both hormones of about 625 μmol/kg. Various derivatives of benzoic acid (625 μmol/kg) were administered and structure-activity relationships were examined. A single carboxylic group was essential for stimulating insulin and glucagon secretion, since both hormone responses were abolished with compounds in which the carboxylic group was replaced by sulfonic or phosphoric groups, or in which another carboxylic element was introduced (phthalic acids). Most of the compounds which introduced other elements (amino and hydroxy groups, and halogens) onto the benzene ring had an altered stimulating activity. Thus the pancreatic endocrine system can recognize the chemical structure of benzoic acid and its derivatives in detail and induce insulin and glucagon secretion in sheep.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Benzoates - administration & dosage</subject><subject>Benzoates - chemistry</subject><subject>Benzoates - pharmacology</subject><subject>Benzoic acid</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine pancreas</subject><subject>Glucagon</subject><subject>Glucagon - blood</subject><subject>Glucagon - metabolism</subject><subject>Injections, Intravenous</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Ruminant</subject><subject>Sheep</subject><subject>Structure-Activity Relationship</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxYMo9bX2GyjMQkq7GL2ZJJNkI0hpq1Dqpl2HTHLzjMzLPJM3Bf30zfvDW-oq5J7fPRzOJeQ9hU8UaP8ZgPK201pfanFVP7prH16RBVVStyBp95osjshbclrKLwAQuhMn5EQKpanUC_J4EwK6TWmm0AyY_k7RNdZF39jkm1jnNtlxWs5YidTEVOYxpp24HGdnl3VY0GXcxJ3clJ-I63fkTbBjwfPDe0aebm8er7-19z_uvl9_vW8dp3LT9opy1XnF6MCYDd4GgZ6CwoDoYVBoB-65pRZQBC976AXnoHomB8tAMXZGLva-6zz9rhE3ZhWLw3G0Cae5GCklANP8vyCV1ZZrqCDfgy5PpWQMZp3jyuY_hoLZtm62lZptpUYLs2vdPNS1Dwf_eVihPy4daq76x4Nui7NjyDa5WI4YE4rDLuaXPYa1tOeI2RQXMTn0MdcjGT_Ff-d4Acd8ncQ</recordid><startdate>19950704</startdate><enddate>19950704</enddate><creator>Mineo, Hitoshi</creator><creator>Ohdate, Tatsuya</creator><creator>Fukumura, Kouichi</creator><creator>Katayama, Toyohiro</creator><creator>Onaga, Takenori</creator><creator>Kato, Seiyu</creator><creator>Yanaihara, Noboru</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19950704</creationdate><title>Effects of benzoic acid and its analogues on insulin and glucagon secretion in sheep</title><author>Mineo, Hitoshi ; Ohdate, Tatsuya ; Fukumura, Kouichi ; Katayama, Toyohiro ; Onaga, Takenori ; Kato, Seiyu ; Yanaihara, Noboru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-681482d831b33afdaf5ed108efeed0b8eab4d4a1a0e5fd760654408637ba30833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Benzoates - administration & dosage</topic><topic>Benzoates - chemistry</topic><topic>Benzoates - pharmacology</topic><topic>Benzoic acid</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine pancreas</topic><topic>Glucagon</topic><topic>Glucagon - blood</topic><topic>Glucagon - metabolism</topic><topic>Injections, Intravenous</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Ruminant</topic><topic>Sheep</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mineo, Hitoshi</creatorcontrib><creatorcontrib>Ohdate, Tatsuya</creatorcontrib><creatorcontrib>Fukumura, Kouichi</creatorcontrib><creatorcontrib>Katayama, Toyohiro</creatorcontrib><creatorcontrib>Onaga, Takenori</creatorcontrib><creatorcontrib>Kato, Seiyu</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mineo, Hitoshi</au><au>Ohdate, Tatsuya</au><au>Fukumura, Kouichi</au><au>Katayama, Toyohiro</au><au>Onaga, Takenori</au><au>Kato, Seiyu</au><au>Yanaihara, Noboru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of benzoic acid and its analogues on insulin and glucagon secretion in sheep</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1995-07-04</date><risdate>1995</risdate><volume>280</volume><issue>2</issue><spage>149</spage><epage>154</epage><pages>149-154</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effects of benzoic acid and its analogues on insulin and glucagon secretion were investigated in conscious sheep. Intravenous injections of benzoic acid increased plasma insulin and glucagon concentrations in a dose-dependent manner between 39–1250 μmol/kg, with ED
50s for increasing both hormones of about 625 μmol/kg. Various derivatives of benzoic acid (625 μmol/kg) were administered and structure-activity relationships were examined. A single carboxylic group was essential for stimulating insulin and glucagon secretion, since both hormone responses were abolished with compounds in which the carboxylic group was replaced by sulfonic or phosphoric groups, or in which another carboxylic element was introduced (phthalic acids). Most of the compounds which introduced other elements (amino and hydroxy groups, and halogens) onto the benzene ring had an altered stimulating activity. Thus the pancreatic endocrine system can recognize the chemical structure of benzoic acid and its derivatives in detail and induce insulin and glucagon secretion in sheep.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7589179</pmid><doi>10.1016/0014-2999(95)00192-N</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1995-07, Vol.280 (2), p.149-154 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Benzoates - administration & dosage Benzoates - chemistry Benzoates - pharmacology Benzoic acid Biological and medical sciences Blood Glucose - metabolism Dose-Response Relationship, Drug Endocrine pancreas Glucagon Glucagon - blood Glucagon - metabolism Injections, Intravenous Insulin Insulin - blood Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Medical sciences Pharmacology. Drug treatments Ruminant Sheep Structure-Activity Relationship |
| title | Effects of benzoic acid and its analogues on insulin and glucagon secretion in sheep |
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