Perinatal undernutrition alters hypothermic responses to different central agonists in recovered adult rats
Adult rats submitted to a protein deprivation schedule at perinatal age and later rehabilitated with balanced laboratory chow were studied in order to evaluate the hypothermic effect induced by the following central agonists: apomorphine, naphazoline, clonidine, diazepam, 5-MeODMT and oxotremorine....
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| Veröffentlicht in: | Neuropharmacology 1987-07, Vol.26 (7A), p.771-774 |
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| container_title | Neuropharmacology |
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| creator | BRIONI, J. D ORSINGHER, O. A |
| description | Adult rats submitted to a protein deprivation schedule at perinatal age and later rehabilitated with balanced laboratory chow were studied in order to evaluate the hypothermic effect induced by the following central agonists: apomorphine, naphazoline, clonidine, diazepam, 5-MeODMT and oxotremorine. Deprived animals showed an enhanced reactivity to the hypothermic effect of apomorphine, naphazoline and diazepam, while a reduced responsiveness to clonidine was observed. Hypothermic responses to oxotremorine and 5-MeODMT were similar between both groups. These results stressed the functional relevancy of neurochemical changes induced by early undernutrition that may persist into adult life after nutritional recovery. |
| doi_str_mv | 10.1016/0028-3908(87)90240-1 |
| format | Article |
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D ; ORSINGHER, O. A</creator><creatorcontrib>BRIONI, J. D ; ORSINGHER, O. A</creatorcontrib><description>Adult rats submitted to a protein deprivation schedule at perinatal age and later rehabilitated with balanced laboratory chow were studied in order to evaluate the hypothermic effect induced by the following central agonists: apomorphine, naphazoline, clonidine, diazepam, 5-MeODMT and oxotremorine. Deprived animals showed an enhanced reactivity to the hypothermic effect of apomorphine, naphazoline and diazepam, while a reduced responsiveness to clonidine was observed. Hypothermic responses to oxotremorine and 5-MeODMT were similar between both groups. These results stressed the functional relevancy of neurochemical changes induced by early undernutrition that may persist into adult life after nutritional recovery.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/0028-3908(87)90240-1</identifier><identifier>PMID: 3627385</identifier><identifier>CODEN: NEPHBW</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Animals ; Animals, Newborn - physiology ; Biological and medical sciences ; Body Temperature - drug effects ; Body Weight ; Central Nervous System - physiopathology ; Fetus - physiology ; Hypothermia - chemically induced ; Male ; Medical sciences ; Miscellaneous ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. 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A</creatorcontrib><title>Perinatal undernutrition alters hypothermic responses to different central agonists in recovered adult rats</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Adult rats submitted to a protein deprivation schedule at perinatal age and later rehabilitated with balanced laboratory chow were studied in order to evaluate the hypothermic effect induced by the following central agonists: apomorphine, naphazoline, clonidine, diazepam, 5-MeODMT and oxotremorine. Deprived animals showed an enhanced reactivity to the hypothermic effect of apomorphine, naphazoline and diazepam, while a reduced responsiveness to clonidine was observed. Hypothermic responses to oxotremorine and 5-MeODMT were similar between both groups. These results stressed the functional relevancy of neurochemical changes induced by early undernutrition that may persist into adult life after nutritional recovery.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Weight</subject><subject>Central Nervous System - physiopathology</subject><subject>Fetus - physiology</subject><subject>Hypothermia - chemically induced</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Protein Deficiency - pathology</topic><topic>Protein Deficiency - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRIONI, J. D</creatorcontrib><creatorcontrib>ORSINGHER, O. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRIONI, J. D</au><au>ORSINGHER, O. 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| ispartof | Neuropharmacology, 1987-07, Vol.26 (7A), p.771-774 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Animals, Newborn - physiology Biological and medical sciences Body Temperature - drug effects Body Weight Central Nervous System - physiopathology Fetus - physiology Hypothermia - chemically induced Male Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Protein Deficiency - pathology Protein Deficiency - physiopathology Rats Rats, Inbred Strains |
| title | Perinatal undernutrition alters hypothermic responses to different central agonists in recovered adult rats |
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