Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis
Increased oxidation of fat is an important host response to sepsis, and carnitine is essential for long-chain fatty acid oxidation. Because neonates have low levels of carnitine, their ability to respond to a septic insult may be impaired. The purpose of this study was to compare fatty acid and carn...
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| Veröffentlicht in: | Journal of pediatric surgery 1995-07, Vol.30 (7), p.959-966 |
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| container_title | Journal of pediatric surgery |
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| creator | Linz, David N Garcia, Victor F Arya, Gaira Hug, George Tombragel, Esther Landrigan, Evelyn Chuck, Gail Tsoras, Monica Ryan, Mary Ziegler, Moritz M |
| description | Increased oxidation of fat is an important host response to sepsis, and carnitine is essential for long-chain fatty acid oxidation. Because neonates have low levels of carnitine, their ability to respond to a septic insult may be impaired. The purpose of this study was to compare fatty acid and carnitine metabolism in septic weanling (60 to 85 g) and septic adult (285 to 310 g) rats. Sepsis was induced in weanling and adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). The rats were killed 16 hours after CLP or sham operation, and serum glucose, lactate, β-hydroxybutyrate, fatty acid, carnitine, liver fatty acid, and tissue carnitine levels were measured. The data suggest that during sepsis weanling rats may be more dependent on fatty acid oxidation than adult rats are, as evidenced by their elevated serum fatty acid and acylcarnitine levels, and relative hypoglycemia and hyperketonemia. In addition, although total serum carnitine levels were increased in both adult and weanling septic rats, tissue carnitine levels of weanling rats became significantly depleted during sepsis, unlike in adult rats. This study supports further investigation regarding the role of exogenous carnitine in newborn sepsis. |
| doi_str_mv | 10.1016/0022-3468(95)90321-6 |
| format | Article |
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Because neonates have low levels of carnitine, their ability to respond to a septic insult may be impaired. The purpose of this study was to compare fatty acid and carnitine metabolism in septic weanling (60 to 85 g) and septic adult (285 to 310 g) rats. Sepsis was induced in weanling and adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). The rats were killed 16 hours after CLP or sham operation, and serum glucose, lactate, β-hydroxybutyrate, fatty acid, carnitine, liver fatty acid, and tissue carnitine levels were measured. The data suggest that during sepsis weanling rats may be more dependent on fatty acid oxidation than adult rats are, as evidenced by their elevated serum fatty acid and acylcarnitine levels, and relative hypoglycemia and hyperketonemia. In addition, although total serum carnitine levels were increased in both adult and weanling septic rats, tissue carnitine levels of weanling rats became significantly depleted during sepsis, unlike in adult rats. This study supports further investigation regarding the role of exogenous carnitine in newborn sepsis.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/0022-3468(95)90321-6</identifier><identifier>PMID: 7472953</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3-Hydroxybutyric Acid ; Aging - metabolism ; Animals ; Bacterial Infections - metabolism ; Blood Glucose - analysis ; Carnitine - blood ; Carnitine - metabolism ; Fatty Acids - blood ; Fatty Acids - metabolism ; Fatty Acids, Nonesterified - blood ; Fatty Acids, Nonesterified - metabolism ; Hydroxybutyrates - blood ; Hypoglycemia - blood ; Ketones - blood ; Kidney - metabolism ; Lactates - blood ; Liver - metabolism ; Male ; Muscle, Skeletal - metabolism ; Myocardium - metabolism ; Oxidation-Reduction ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution ; Weaning</subject><ispartof>Journal of pediatric surgery, 1995-07, Vol.30 (7), p.959-966</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3d931383b36556f64e30a9453d51f2e8eabc01faf060be54a8bf992666499f643</citedby><cites>FETCH-LOGICAL-c357t-3d931383b36556f64e30a9453d51f2e8eabc01faf060be54a8bf992666499f643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022346895903216$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7472953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linz, David N</creatorcontrib><creatorcontrib>Garcia, Victor F</creatorcontrib><creatorcontrib>Arya, Gaira</creatorcontrib><creatorcontrib>Hug, George</creatorcontrib><creatorcontrib>Tombragel, Esther</creatorcontrib><creatorcontrib>Landrigan, Evelyn</creatorcontrib><creatorcontrib>Chuck, Gail</creatorcontrib><creatorcontrib>Tsoras, Monica</creatorcontrib><creatorcontrib>Ryan, Mary</creatorcontrib><creatorcontrib>Ziegler, Moritz M</creatorcontrib><title>Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Increased oxidation of fat is an important host response to sepsis, and carnitine is essential for long-chain fatty acid oxidation. Because neonates have low levels of carnitine, their ability to respond to a septic insult may be impaired. The purpose of this study was to compare fatty acid and carnitine metabolism in septic weanling (60 to 85 g) and septic adult (285 to 310 g) rats. Sepsis was induced in weanling and adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). The rats were killed 16 hours after CLP or sham operation, and serum glucose, lactate, β-hydroxybutyrate, fatty acid, carnitine, liver fatty acid, and tissue carnitine levels were measured. The data suggest that during sepsis weanling rats may be more dependent on fatty acid oxidation than adult rats are, as evidenced by their elevated serum fatty acid and acylcarnitine levels, and relative hypoglycemia and hyperketonemia. In addition, although total serum carnitine levels were increased in both adult and weanling septic rats, tissue carnitine levels of weanling rats became significantly depleted during sepsis, unlike in adult rats. This study supports further investigation regarding the role of exogenous carnitine in newborn sepsis.</description><subject>3-Hydroxybutyric Acid</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Bacterial Infections - metabolism</subject><subject>Blood Glucose - analysis</subject><subject>Carnitine - blood</subject><subject>Carnitine - metabolism</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Hydroxybutyrates - blood</subject><subject>Hypoglycemia - blood</subject><subject>Ketones - blood</subject><subject>Kidney - metabolism</subject><subject>Lactates - blood</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tissue Distribution</subject><subject>Weaning</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxRyEj1Uk6ZJm4sgi1-w4EHFY0iTiUT6sSapsP_e1l08ehqYeeYd5kHolJIrSqi4JiTPM1aI6kLyS0lYTjOxh-aUM5pxwsp9NP9DDtFRjJ-EjG1CZ2hWFmUuOZujl3fQXeO7D6w7i7UdmoSDThFb7xwE7DvsdEobrI23v4zRofPJd4BbSLruGx9bbIcwZURYRx-P0YHTTYSTXV2gt_u71-Vjtnp-eFrerjLDeJkyZiWjrGI1E5wLJwpgRMuCM8upy6ECXRtCnXZEkBp4oavaSZkLIQopR5wt0Pk2dx36rwFiUq2PBppGd9APUZWlkBWvJrDYgib0MQZwah18q8NGUaIml2oSpSZRSnL161KJce1slz_ULdi_pZ28cX6zncP45LeHoKLx0BmwPoBJyvb-_wM_NbiCkw</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Linz, David N</creator><creator>Garcia, Victor F</creator><creator>Arya, Gaira</creator><creator>Hug, George</creator><creator>Tombragel, Esther</creator><creator>Landrigan, Evelyn</creator><creator>Chuck, Gail</creator><creator>Tsoras, Monica</creator><creator>Ryan, Mary</creator><creator>Ziegler, Moritz M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis</title><author>Linz, David N ; Garcia, Victor F ; Arya, Gaira ; Hug, George ; Tombragel, Esther ; Landrigan, Evelyn ; Chuck, Gail ; Tsoras, Monica ; Ryan, Mary ; Ziegler, Moritz M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3d931383b36556f64e30a9453d51f2e8eabc01faf060be54a8bf992666499f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>3-Hydroxybutyric Acid</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Bacterial Infections - metabolism</topic><topic>Blood Glucose - analysis</topic><topic>Carnitine - blood</topic><topic>Carnitine - metabolism</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids - metabolism</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Hydroxybutyrates - blood</topic><topic>Hypoglycemia - blood</topic><topic>Ketones - blood</topic><topic>Kidney - metabolism</topic><topic>Lactates - blood</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tissue Distribution</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linz, David N</creatorcontrib><creatorcontrib>Garcia, Victor F</creatorcontrib><creatorcontrib>Arya, Gaira</creatorcontrib><creatorcontrib>Hug, George</creatorcontrib><creatorcontrib>Tombragel, Esther</creatorcontrib><creatorcontrib>Landrigan, Evelyn</creatorcontrib><creatorcontrib>Chuck, Gail</creatorcontrib><creatorcontrib>Tsoras, Monica</creatorcontrib><creatorcontrib>Ryan, Mary</creatorcontrib><creatorcontrib>Ziegler, Moritz M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linz, David N</au><au>Garcia, Victor F</au><au>Arya, Gaira</au><au>Hug, George</au><au>Tombragel, Esther</au><au>Landrigan, Evelyn</au><au>Chuck, Gail</au><au>Tsoras, Monica</au><au>Ryan, Mary</au><au>Ziegler, Moritz M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>30</volume><issue>7</issue><spage>959</spage><epage>966</epage><pages>959-966</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Increased oxidation of fat is an important host response to sepsis, and carnitine is essential for long-chain fatty acid oxidation. Because neonates have low levels of carnitine, their ability to respond to a septic insult may be impaired. The purpose of this study was to compare fatty acid and carnitine metabolism in septic weanling (60 to 85 g) and septic adult (285 to 310 g) rats. Sepsis was induced in weanling and adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). The rats were killed 16 hours after CLP or sham operation, and serum glucose, lactate, β-hydroxybutyrate, fatty acid, carnitine, liver fatty acid, and tissue carnitine levels were measured. The data suggest that during sepsis weanling rats may be more dependent on fatty acid oxidation than adult rats are, as evidenced by their elevated serum fatty acid and acylcarnitine levels, and relative hypoglycemia and hyperketonemia. In addition, although total serum carnitine levels were increased in both adult and weanling septic rats, tissue carnitine levels of weanling rats became significantly depleted during sepsis, unlike in adult rats. 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| ispartof | Journal of pediatric surgery, 1995-07, Vol.30 (7), p.959-966 |
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| subjects | 3-Hydroxybutyric Acid Aging - metabolism Animals Bacterial Infections - metabolism Blood Glucose - analysis Carnitine - blood Carnitine - metabolism Fatty Acids - blood Fatty Acids - metabolism Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Hydroxybutyrates - blood Hypoglycemia - blood Ketones - blood Kidney - metabolism Lactates - blood Liver - metabolism Male Muscle, Skeletal - metabolism Myocardium - metabolism Oxidation-Reduction Rats Rats, Sprague-Dawley Tissue Distribution Weaning |
| title | Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis |
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