Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein

Ketanserin has higher affinity for 5-HT 1Dα receptors compared to 5-HT 1Dβ receptors, whereas, GR127935 ( N-[4-methoxy-3-(4-methyl-1-mpiperazinyl)phenyl]-2(methyl-4(-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1-biphenyl]-4-carboxamide), a novel and selective 5-HT 1D receptor antagonist, has higher affinity f...

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Veröffentlicht in:	European journal of pharmacology 1995-09, Vol.283 (1), p.199-206
Hauptverfasser:	Razzaque, Zerin, Longmore, Jeanette, Hill, Raymond G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 1D receptor Animals Dose-Response Relationship, Drug GR127935 Guinea Pigs Jugular vein, guinea-pig Jugular Veins - drug effects Ketanserin Ketanserin - pharmacology Male Myenteric Plexus - drug effects Nifedipine - pharmacology Oxadiazoles - pharmacology Piperazines - pharmacology Rabbits Saphenous Vein - drug effects Saphenous vein, rabbit Serotonin - pharmacology Serotonin Antagonists - pharmacology Sumatriptan - pharmacology
Online-Zugang:	Volltext
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