Is Polyamine Decrease a Common Feature of Apoptosis? Evidence from γ Rays- and Heat Shock-Induced Cell Death

Here we report that in rat thymocytes undergoing apoptosis upon two different stimuli, such as heat shock treatment and γ irradiation, an early mRNA accumulation of ornithine decarboxylase (ODC) - the rate-limiting enzyme of polyamine biosynthesis - was followed by a very marked increase in ODC acti...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-11, Vol.216 (2), p.708-714
Hauptverfasser:	Grassilli, E., Desiderio, M.A., Bellesia, E., Salomoni, P., Benatti, F., Franceschi, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Apoptosis - radiation effects Cell Death - drug effects Cells, Cultured Chromatography, High Pressure Liquid DNA - isolation & purification DNA - radiation effects Electrophoresis, Agar Gel Gamma Rays Hot Temperature Kinetics Ornithine Decarboxylase - metabolism Polyamines - metabolism Putrescine - metabolism Rats Rats, Sprague-Dawley Spermidine - metabolism Spermine - metabolism Thymus Gland - cytology Thymus Gland - pathology Thymus Gland - radiation effects Time Factors
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