Different tissue responses for iodine and iodide in rat thyroid and mammary glands
This research describes the effects of short-term elemental iodine (I2) and iodide (I-) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the...
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| Veröffentlicht in: | Biological trace element research 1995-07, Vol.49 (1), p.9-19 |
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| creator | Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.) Grotkowski, C.E Connolly, C.P Ghent, W.R |
| description | This research describes the effects of short-term elemental iodine (I2) and iodide (I-) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I- and I2, whereas serum total thyroxine approached the normal control with both I- and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I-. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I- when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I-; and periductal fibrosis was markedly reduced with I2, but remained severe with I-. Thus, orally administered I2 or I- in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific. |
| doi_str_mv | 10.1007/BF02788999 |
| format | Article |
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Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I- and I2, whereas serum total thyroxine approached the normal control with both I- and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I-. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I- when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I-; and periductal fibrosis was markedly reduced with I2, but remained severe with I-. Thus, orally administered I2 or I- in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/BF02788999</identifier><identifier>PMID: 7577324</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Body Weight - drug effects ; CARENCE EN SUBSTANCE NUTRITIVE ; DEFICIENCIAS NUTRITIVAS ; Female ; GLANDE MAMMAIRE ; GLANDULA TIROIDE ; GLANDULAS MAMARIAS ; HISTOLOGY ; IODE ; IODIDES ; Iodides - pharmacology ; IODINE ; Iodine - pharmacology ; IODURE ; MAMMARY GLANDS ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - physiology ; METABOLISM ; METABOLISME ; METABOLISMO ; NUTRIENT DEFICIENCIES ; Organ Size - drug effects ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; THYROID GLAND ; Thyroid Gland - anatomy & histology ; Thyroid Gland - drug effects ; Thyroid Gland - physiology ; THYROIDE ; YODO ; YODUROS</subject><ispartof>Biological trace element research, 1995-07, Vol.49 (1), p.9-19</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-7db2908fc0bf3495bc388d2ac1acff70b37115bfe9b5cd1464c055a91f1c25a53</citedby><cites>FETCH-LOGICAL-c301t-7db2908fc0bf3495bc388d2ac1acff70b37115bfe9b5cd1464c055a91f1c25a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7577324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.)</creatorcontrib><creatorcontrib>Grotkowski, C.E</creatorcontrib><creatorcontrib>Connolly, C.P</creatorcontrib><creatorcontrib>Ghent, W.R</creatorcontrib><title>Different tissue responses for iodine and iodide in rat thyroid and mammary glands</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>This research describes the effects of short-term elemental iodine (I2) and iodide (I-) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I- and I2, whereas serum total thyroxine approached the normal control with both I- and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I-. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I- when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I-; and periductal fibrosis was markedly reduced with I2, but remained severe with I-. Thus, orally administered I2 or I- in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific.</description><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>CARENCE EN SUBSTANCE NUTRITIVE</subject><subject>DEFICIENCIAS NUTRITIVAS</subject><subject>Female</subject><subject>GLANDE MAMMAIRE</subject><subject>GLANDULA TIROIDE</subject><subject>GLANDULAS MAMARIAS</subject><subject>HISTOLOGY</subject><subject>IODE</subject><subject>IODIDES</subject><subject>Iodides - pharmacology</subject><subject>IODINE</subject><subject>Iodine - pharmacology</subject><subject>IODURE</subject><subject>MAMMARY GLANDS</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - physiology</subject><subject>METABOLISM</subject><subject>METABOLISME</subject><subject>METABOLISMO</subject><subject>NUTRIENT DEFICIENCIES</subject><subject>Organ Size - drug effects</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>THYROID GLAND</subject><subject>Thyroid Gland - anatomy & histology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>THYROIDE</subject><subject>YODO</subject><subject>YODUROS</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEYhIMotVYvHgUhJw_Caj42m-So1apQENSeQzYfNdLd1GT30H_v1hY9vfMyD8MwAJxjdIMR4rf3M0S4EFLKAzDGjMkCcYIOwRjhihalFOUxOMn5CyHMiaQjMOKMc0rKMXh7CN675NoOdiHn3sHk8jq22WXoY4Ih2tA6qFv7K62DoYVJD_TnJsVgf51GN41OG7hcDV8-BUder7I7298JWMweP6bPxfz16WV6Ny8MRbgruK2JRMIbVHtaSlYbKoQl2mBtvOeophxjVnsna2YsLqvSIMa0xB4bwjSjE3C1y12n-N273KkmZONWQwkX-6w4r2RZoS14vQNNijkn59U6hW1hhZHaDqj-Bxzgy31qXzfO_qH7xQb_Yud7HZVeppDV4l1WpMJC0B-qzHNu</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.)</creator><creator>Grotkowski, C.E</creator><creator>Connolly, C.P</creator><creator>Ghent, W.R</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199507</creationdate><title>Different tissue responses for iodine and iodide in rat thyroid and mammary glands</title><author>Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.) ; Grotkowski, C.E ; Connolly, C.P ; Ghent, W.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-7db2908fc0bf3495bc388d2ac1acff70b37115bfe9b5cd1464c055a91f1c25a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>CARENCE EN SUBSTANCE NUTRITIVE</topic><topic>DEFICIENCIAS NUTRITIVAS</topic><topic>Female</topic><topic>GLANDE MAMMAIRE</topic><topic>GLANDULA TIROIDE</topic><topic>GLANDULAS MAMARIAS</topic><topic>HISTOLOGY</topic><topic>IODE</topic><topic>IODIDES</topic><topic>Iodides - pharmacology</topic><topic>IODINE</topic><topic>Iodine - pharmacology</topic><topic>IODURE</topic><topic>MAMMARY GLANDS</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - physiology</topic><topic>METABOLISM</topic><topic>METABOLISME</topic><topic>METABOLISMO</topic><topic>NUTRIENT DEFICIENCIES</topic><topic>Organ Size - drug effects</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>THYROID GLAND</topic><topic>Thyroid Gland - anatomy & histology</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>THYROIDE</topic><topic>YODO</topic><topic>YODUROS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.)</creatorcontrib><creatorcontrib>Grotkowski, C.E</creatorcontrib><creatorcontrib>Connolly, C.P</creatorcontrib><creatorcontrib>Ghent, W.R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eskin, B.A. (Medical College of Pennsylvania, Philadelphia, PA.)</au><au>Grotkowski, C.E</au><au>Connolly, C.P</au><au>Ghent, W.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different tissue responses for iodine and iodide in rat thyroid and mammary glands</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>1995-07</date><risdate>1995</risdate><volume>49</volume><issue>1</issue><spage>9</spage><epage>19</epage><pages>9-19</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>This research describes the effects of short-term elemental iodine (I2) and iodide (I-) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I- and I2, whereas serum total thyroxine approached the normal control with both I- and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I-. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I- when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I-; and periductal fibrosis was markedly reduced with I2, but remained severe with I-. Thus, orally administered I2 or I- in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific.</abstract><cop>United States</cop><pmid>7577324</pmid><doi>10.1007/BF02788999</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Body Weight - drug effects CARENCE EN SUBSTANCE NUTRITIVE DEFICIENCIAS NUTRITIVAS Female GLANDE MAMMAIRE GLANDULA TIROIDE GLANDULAS MAMARIAS HISTOLOGY IODE IODIDES Iodides - pharmacology IODINE Iodine - pharmacology IODURE MAMMARY GLANDS Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Glands, Animal - physiology METABOLISM METABOLISME METABOLISMO NUTRIENT DEFICIENCIES Organ Size - drug effects RAT RATA RATS Rats, Sprague-Dawley THYROID GLAND Thyroid Gland - anatomy & histology Thyroid Gland - drug effects Thyroid Gland - physiology THYROIDE YODO YODUROS |
| title | Different tissue responses for iodine and iodide in rat thyroid and mammary glands |
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