Factors Affecting Quality of Ulcer Healing After Lansoprazole Treatment
To evaluate endogenous and exogenous factors affecting the quality of ulcer healing produced by proton pump inhibitors, gastric acid pH, serum gastrin, and serum pepsinogen (PG) I and II were measured in peptic ulcer patients before and after treatment with lansoprazole 30 mg once daily. Lansoprazol...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1995, Vol.20 Suppl 2, p.S62-S66 |
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| container_title | Journal of clinical gastroenterology |
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| creator | Ito, Go Nakagawara, Masanori Watanabe, Fumitoshi Ooi, Sigeko Nawano, Mitsumasa Hanai, Hiroyuki Kaneko, Eizo |
| description | To evaluate endogenous and exogenous factors affecting the quality of ulcer healing produced by proton pump inhibitors, gastric acid pH, serum gastrin, and serum pepsinogen (PG) I and II were measured in peptic ulcer patients before and after treatment with lansoprazole 30 mg once daily. Lansoprazole achieved more rapid scarring in duodenal ulcer (n = 34), with a healing rate of 97.1 % after 6 weeks, than in gastric ulcer (n = 56), with a healing rate of 92.8% after 8 weeks. Scarring was the most rapid in gastroduodenal ulcer (n = 8), with a healing rate of 100% after 8 weeks, but the rate of complete scarring was the lowest (37.5%). Lower gastric acidity and lower PG I:II ratio were associated with poor quality ulcer scarring in patients with gastric ulcers, but the opposite was true for those with duodenal and gastroduodenal ulcers. For gastric ulcers, not only ulcer size but also mucosal atrophy was an important factor in ulcer healing. Smoking and alcohol consumption had little effect on the quality of ulcer healing during treatment. These results suggest that there are a number of differences between gastric ulcers and duodenal ulcers in terms of the quality of ulcer healing after lansoprazole treatment. |
| doi_str_mv | 10.1097/00004836-199506002-00017 |
| format | Article |
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Lansoprazole achieved more rapid scarring in duodenal ulcer (n = 34), with a healing rate of 97.1 % after 6 weeks, than in gastric ulcer (n = 56), with a healing rate of 92.8% after 8 weeks. Scarring was the most rapid in gastroduodenal ulcer (n = 8), with a healing rate of 100% after 8 weeks, but the rate of complete scarring was the lowest (37.5%). Lower gastric acidity and lower PG I:II ratio were associated with poor quality ulcer scarring in patients with gastric ulcers, but the opposite was true for those with duodenal and gastroduodenal ulcers. For gastric ulcers, not only ulcer size but also mucosal atrophy was an important factor in ulcer healing. Smoking and alcohol consumption had little effect on the quality of ulcer healing during treatment. These results suggest that there are a number of differences between gastric ulcers and duodenal ulcers in terms of the quality of ulcer healing after lansoprazole treatment.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-199506002-00017</identifier><identifier>PMID: 7594344</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles ; Age Factors ; Alcohol Drinking - adverse effects ; Anti-Ulcer Agents - therapeutic use ; Biological and medical sciences ; Digestive system ; Duodenal Ulcer - drug therapy ; Duodenal Ulcer - pathology ; Female ; Gastric Acid - metabolism ; Gastrins - blood ; Humans ; Lansoprazole ; Male ; Medical sciences ; Middle Aged ; Omeprazole - analogs & derivatives ; Omeprazole - therapeutic use ; Pepsinogens - blood ; Peptic Ulcer - drug therapy ; Peptic Ulcer - pathology ; Pharmacology. Drug treatments ; Proton Pump Inhibitors ; Sex Factors ; Smoking - adverse effects ; Stomach Ulcer - drug therapy ; Stomach Ulcer - pathology</subject><ispartof>Journal of clinical gastroenterology, 1995, Vol.20 Suppl 2, p.S62-S66</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-eb4078da16df1058e055a30b20c71d5ae17adbf35c6ae2ef5f118e5e525254173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3608292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7594344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Go</creatorcontrib><creatorcontrib>Nakagawara, Masanori</creatorcontrib><creatorcontrib>Watanabe, Fumitoshi</creatorcontrib><creatorcontrib>Ooi, Sigeko</creatorcontrib><creatorcontrib>Nawano, Mitsumasa</creatorcontrib><creatorcontrib>Hanai, Hiroyuki</creatorcontrib><creatorcontrib>Kaneko, Eizo</creatorcontrib><title>Factors Affecting Quality of Ulcer Healing After Lansoprazole Treatment</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>To evaluate endogenous and exogenous factors affecting the quality of ulcer healing produced by proton pump inhibitors, gastric acid pH, serum gastrin, and serum pepsinogen (PG) I and II were measured in peptic ulcer patients before and after treatment with lansoprazole 30 mg once daily. Lansoprazole achieved more rapid scarring in duodenal ulcer (n = 34), with a healing rate of 97.1 % after 6 weeks, than in gastric ulcer (n = 56), with a healing rate of 92.8% after 8 weeks. Scarring was the most rapid in gastroduodenal ulcer (n = 8), with a healing rate of 100% after 8 weeks, but the rate of complete scarring was the lowest (37.5%). Lower gastric acidity and lower PG I:II ratio were associated with poor quality ulcer scarring in patients with gastric ulcers, but the opposite was true for those with duodenal and gastroduodenal ulcers. For gastric ulcers, not only ulcer size but also mucosal atrophy was an important factor in ulcer healing. Smoking and alcohol consumption had little effect on the quality of ulcer healing during treatment. These results suggest that there are a number of differences between gastric ulcers and duodenal ulcers in terms of the quality of ulcer healing after lansoprazole treatment.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles</subject><subject>Age Factors</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Duodenal Ulcer - pathology</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastrins - blood</subject><subject>Humans</subject><subject>Lansoprazole</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Omeprazole - analogs & derivatives</subject><subject>Omeprazole - therapeutic use</subject><subject>Pepsinogens - blood</subject><subject>Peptic Ulcer - drug therapy</subject><subject>Peptic Ulcer - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proton Pump Inhibitors</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - pathology</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFPwyAYhonRzDn9CSY9GG9VKFDKcVncZrLEmGxnQumHq7J2Qhszf73Mzd2EA-F7nw_IA0IJwQ8ES_GI42AFzVMiJcc5xlkaK0ScoSHhVKYZpuQcDTGRMRASX6KrEN73BKVkgAaCS0YZG6LZVJuu9SEZWwumq5u35LXXru52SWuTlTPgkznEQgzGtou7hW5Cu_X6u3WQLD3obgNNd40urHYBbo7rCK2mT8vJPF28zJ4n40VqaMFECiXDoqg0yStLMC8Ac64pLjNsBKm4BiJ0VVrKTa4hA8stIQVw4FmcLL5-hO4P5259-9lD6NSmDgac0w20fVBC5JIyTiNYHEDj2xA8WLX19Ub7nSJY7R2qP4fq5FD9Ooytt8c7-nID1anxKC3md8dcB6Od9boxdThhNMdFJrOIsQP21booLny4_gu8Wkeb3Vr994P0B27Ah_k</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Ito, Go</creator><creator>Nakagawara, Masanori</creator><creator>Watanabe, Fumitoshi</creator><creator>Ooi, Sigeko</creator><creator>Nawano, Mitsumasa</creator><creator>Hanai, Hiroyuki</creator><creator>Kaneko, Eizo</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>1995</creationdate><title>Factors Affecting Quality of Ulcer Healing After Lansoprazole Treatment</title><author>Ito, Go ; Nakagawara, Masanori ; Watanabe, Fumitoshi ; Ooi, Sigeko ; Nawano, Mitsumasa ; Hanai, Hiroyuki ; Kaneko, Eizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-eb4078da16df1058e055a30b20c71d5ae17adbf35c6ae2ef5f118e5e525254173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles</topic><topic>Age Factors</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Duodenal Ulcer - drug therapy</topic><topic>Duodenal Ulcer - pathology</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastrins - blood</topic><topic>Humans</topic><topic>Lansoprazole</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Omeprazole - analogs & derivatives</topic><topic>Omeprazole - therapeutic use</topic><topic>Pepsinogens - blood</topic><topic>Peptic Ulcer - drug therapy</topic><topic>Peptic Ulcer - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proton Pump Inhibitors</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Go</creatorcontrib><creatorcontrib>Nakagawara, Masanori</creatorcontrib><creatorcontrib>Watanabe, Fumitoshi</creatorcontrib><creatorcontrib>Ooi, Sigeko</creatorcontrib><creatorcontrib>Nawano, Mitsumasa</creatorcontrib><creatorcontrib>Hanai, Hiroyuki</creatorcontrib><creatorcontrib>Kaneko, Eizo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Go</au><au>Nakagawara, Masanori</au><au>Watanabe, Fumitoshi</au><au>Ooi, Sigeko</au><au>Nawano, Mitsumasa</au><au>Hanai, Hiroyuki</au><au>Kaneko, Eizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Affecting Quality of Ulcer Healing After Lansoprazole Treatment</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1995</date><risdate>1995</risdate><volume>20 Suppl 2</volume><spage>S62</spage><epage>S66</epage><pages>S62-S66</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>To evaluate endogenous and exogenous factors affecting the quality of ulcer healing produced by proton pump inhibitors, gastric acid pH, serum gastrin, and serum pepsinogen (PG) I and II were measured in peptic ulcer patients before and after treatment with lansoprazole 30 mg once daily. Lansoprazole achieved more rapid scarring in duodenal ulcer (n = 34), with a healing rate of 97.1 % after 6 weeks, than in gastric ulcer (n = 56), with a healing rate of 92.8% after 8 weeks. Scarring was the most rapid in gastroduodenal ulcer (n = 8), with a healing rate of 100% after 8 weeks, but the rate of complete scarring was the lowest (37.5%). Lower gastric acidity and lower PG I:II ratio were associated with poor quality ulcer scarring in patients with gastric ulcers, but the opposite was true for those with duodenal and gastroduodenal ulcers. For gastric ulcers, not only ulcer size but also mucosal atrophy was an important factor in ulcer healing. Smoking and alcohol consumption had little effect on the quality of ulcer healing during treatment. These results suggest that there are a number of differences between gastric ulcers and duodenal ulcers in terms of the quality of ulcer healing after lansoprazole treatment.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7594344</pmid><doi>10.1097/00004836-199506002-00017</doi></addata></record> |
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| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles Age Factors Alcohol Drinking - adverse effects Anti-Ulcer Agents - therapeutic use Biological and medical sciences Digestive system Duodenal Ulcer - drug therapy Duodenal Ulcer - pathology Female Gastric Acid - metabolism Gastrins - blood Humans Lansoprazole Male Medical sciences Middle Aged Omeprazole - analogs & derivatives Omeprazole - therapeutic use Pepsinogens - blood Peptic Ulcer - drug therapy Peptic Ulcer - pathology Pharmacology. Drug treatments Proton Pump Inhibitors Sex Factors Smoking - adverse effects Stomach Ulcer - drug therapy Stomach Ulcer - pathology |
| title | Factors Affecting Quality of Ulcer Healing After Lansoprazole Treatment |
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