Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecul...
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| Veröffentlicht in: | Nature structural biology 1995-11, Vol.2 (11), p.968-974 |
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| container_end_page | 974 |
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| container_issue | 11 |
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| container_title | Nature structural biology |
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| creator | Swairjo, M A Concha, N O Kaetzel, M A Dedman, J R Seaton, B A |
| description | Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo. |
| doi_str_mv | 10.1038/nsb1195-968 |
| format | Article |
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| ispartof | Nature structural biology, 1995-11, Vol.2 (11), p.968-974 |
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| source | MEDLINE; Nature |
| subjects | Amino Acid Sequence Annexin A5 - chemistry Annexin A5 - metabolism Annexins Calcium - chemistry Calcium - metabolism Membranes - metabolism Models, Molecular Molecular Sequence Data Phosphatidylethanolamines - chemistry Phosphatidylethanolamines - metabolism Phospholipids - chemistry Phospholipids - metabolism Phosphoserine - analogs & derivatives Phosphoserine - chemistry Phosphoserine - metabolism Protein Binding |
| title | Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V |
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