Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: Reduction in spinocerebellar degeneration
Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) were examined in patients with spinocerebellar degeneration (SCD) including olivopontocerebellar atrophy (OPCA), dentatorubropallidoluysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (PD) and sen...
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| Veröffentlicht in: | Life sciences (1973) 1995, Vol.57 (24), p.2231-2235 |
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| container_issue | 24 |
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| container_title | Life sciences (1973) |
| container_volume | 57 |
| creator | Suemaru, Shuso Suemaru, Koso Kawai, Kensuke Miyata, Shinji Nobukuni, Keigo Ihara, Yuetsu Namba, Reiko Urakami, Katsuya Hashimoto, Kozo |
| description | Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) were examined in patients with spinocerebellar degeneration (SCD) including olivopontocerebellar atrophy (OPCA), dentatorubropallidoluysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (PD) and senile dementia of the Alzheimer type (SDAT), and normal aged subjects. CRH concentrations in CSF were significantly reduced in SCD compared to SDAT, PD and normal aged subjects. It is likely that degeneration not only of the cerebral cortex and the limbic system but also of the subcortical structures such as the brainstem and the cerebellum alters levels of CRH in CSF. Together with the recent anatomical and physiological evidence, the results suggest pathophysiological relevance of CRH for the cerebellar symptoms in SCD. |
| doi_str_mv | 10.1016/0024-3205(95)02215-5 |
| format | Article |
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CRH concentrations in CSF were significantly reduced in SCD compared to SDAT, PD and normal aged subjects. It is likely that degeneration not only of the cerebral cortex and the limbic system but also of the subcortical structures such as the brainstem and the cerebellum alters levels of CRH in CSF. Together with the recent anatomical and physiological evidence, the results suggest pathophysiological relevance of CRH for the cerebellar symptoms in SCD.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(95)02215-5</identifier><identifier>PMID: 7475976</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Aged ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer' s disease ; cerebrospinal fluid ; corticotropin-releasing hormone ; Corticotropin-Releasing Hormone - cerebrospinal fluid ; Dementia ; DRPLA ; Friedreich Ataxia - cerebrospinal fluid ; Friedreich' s ataxia ; Humans ; Middle Aged ; Nervous System Diseases - cerebrospinal fluid ; OPCA ; Parkinson Disease - cerebrospinal fluid ; Parkinson' s disease ; senile dementia ; spinocerebellar degeneration ; Spinocerebellar Degenerations - cerebrospinal fluid</subject><ispartof>Life sciences (1973), 1995, Vol.57 (24), p.2231-2235</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-5263b163904ca5f6310c87730b79c209e84bf590ceef20eb87f43f696a36f6b73</citedby><cites>FETCH-LOGICAL-c388t-5263b163904ca5f6310c87730b79c209e84bf590ceef20eb87f43f696a36f6b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320595022155$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7475976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suemaru, Shuso</creatorcontrib><creatorcontrib>Suemaru, Koso</creatorcontrib><creatorcontrib>Kawai, Kensuke</creatorcontrib><creatorcontrib>Miyata, Shinji</creatorcontrib><creatorcontrib>Nobukuni, Keigo</creatorcontrib><creatorcontrib>Ihara, Yuetsu</creatorcontrib><creatorcontrib>Namba, Reiko</creatorcontrib><creatorcontrib>Urakami, Katsuya</creatorcontrib><creatorcontrib>Hashimoto, Kozo</creatorcontrib><title>Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: Reduction in spinocerebellar degeneration</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) were examined in patients with spinocerebellar degeneration (SCD) including olivopontocerebellar atrophy (OPCA), dentatorubropallidoluysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (PD) and senile dementia of the Alzheimer type (SDAT), and normal aged subjects. CRH concentrations in CSF were significantly reduced in SCD compared to SDAT, PD and normal aged subjects. It is likely that degeneration not only of the cerebral cortex and the limbic system but also of the subcortical structures such as the brainstem and the cerebellum alters levels of CRH in CSF. Together with the recent anatomical and physiological evidence, the results suggest pathophysiological relevance of CRH for the cerebellar symptoms in SCD.</description><subject>Adult</subject><subject>Aged</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer' s disease</subject><subject>cerebrospinal fluid</subject><subject>corticotropin-releasing hormone</subject><subject>Corticotropin-Releasing Hormone - cerebrospinal fluid</subject><subject>Dementia</subject><subject>DRPLA</subject><subject>Friedreich Ataxia - cerebrospinal fluid</subject><subject>Friedreich' s ataxia</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Nervous System Diseases - cerebrospinal fluid</subject><subject>OPCA</subject><subject>Parkinson Disease - cerebrospinal fluid</subject><subject>Parkinson' s disease</subject><subject>senile dementia</subject><subject>spinocerebellar degeneration</subject><subject>Spinocerebellar Degenerations - cerebrospinal fluid</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr2zAUhUXpyNJ0_6ADP5X2wduVZUlWHwoltFshMBjrs7Dlq1TFkTLJDgz242svIXtrnwS63zlXOoeQCwpfKFDxFaAoc1YAv1L8GoqC8pyfkDmtpMpBMHpK5kfkIzlL6QUAOJdsRmaylFxJMSd_lxixiSFtna-7zHaDazMTYu9M6GMYb_OIHdbJ-XX2HOImeMyczzwOMbS4Ro-x7t0Os9alEcN0k_3EdjC9C34CJ-NgpiXYdXXM_muCPycfbN0l_HQ4F-Tp4f7X8nu--vHtcXm3yg2rqj7nhWANFUxBaWpux6-BqaRk0EhlClBYlY3lCgyiLQCbStqSWaFEzYQVjWQLcrn33cbwe8DU641LZnqPxzAkLaVQrCjVuyCVUNIKJrDcg2aMLkW0ehvdpo5_NAU9taOn6PUUvVZc_2tH81H2-eA_NBtsj6JDHeP8dj_HMY2dw6iTcegNti6i6XUb3NsLXgHneaE4</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Suemaru, Shuso</creator><creator>Suemaru, Koso</creator><creator>Kawai, Kensuke</creator><creator>Miyata, Shinji</creator><creator>Nobukuni, Keigo</creator><creator>Ihara, Yuetsu</creator><creator>Namba, Reiko</creator><creator>Urakami, Katsuya</creator><creator>Hashimoto, Kozo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: Reduction in spinocerebellar degeneration</title><author>Suemaru, Shuso ; Suemaru, Koso ; Kawai, Kensuke ; Miyata, Shinji ; Nobukuni, Keigo ; Ihara, Yuetsu ; Namba, Reiko ; Urakami, Katsuya ; Hashimoto, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-5263b163904ca5f6310c87730b79c209e84bf590ceef20eb87f43f696a36f6b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer' s disease</topic><topic>cerebrospinal fluid</topic><topic>corticotropin-releasing hormone</topic><topic>Corticotropin-Releasing Hormone - cerebrospinal fluid</topic><topic>Dementia</topic><topic>DRPLA</topic><topic>Friedreich Ataxia - cerebrospinal fluid</topic><topic>Friedreich' s ataxia</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Nervous System Diseases - cerebrospinal fluid</topic><topic>OPCA</topic><topic>Parkinson Disease - cerebrospinal fluid</topic><topic>Parkinson' s disease</topic><topic>senile dementia</topic><topic>spinocerebellar degeneration</topic><topic>Spinocerebellar Degenerations - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suemaru, Shuso</creatorcontrib><creatorcontrib>Suemaru, Koso</creatorcontrib><creatorcontrib>Kawai, Kensuke</creatorcontrib><creatorcontrib>Miyata, Shinji</creatorcontrib><creatorcontrib>Nobukuni, Keigo</creatorcontrib><creatorcontrib>Ihara, Yuetsu</creatorcontrib><creatorcontrib>Namba, Reiko</creatorcontrib><creatorcontrib>Urakami, Katsuya</creatorcontrib><creatorcontrib>Hashimoto, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suemaru, Shuso</au><au>Suemaru, Koso</au><au>Kawai, Kensuke</au><au>Miyata, Shinji</au><au>Nobukuni, Keigo</au><au>Ihara, Yuetsu</au><au>Namba, Reiko</au><au>Urakami, Katsuya</au><au>Hashimoto, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: Reduction in spinocerebellar degeneration</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1995</date><risdate>1995</risdate><volume>57</volume><issue>24</issue><spage>2231</spage><epage>2235</epage><pages>2231-2235</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) were examined in patients with spinocerebellar degeneration (SCD) including olivopontocerebellar atrophy (OPCA), dentatorubropallidoluysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (PD) and senile dementia of the Alzheimer type (SDAT), and normal aged subjects. CRH concentrations in CSF were significantly reduced in SCD compared to SDAT, PD and normal aged subjects. It is likely that degeneration not only of the cerebral cortex and the limbic system but also of the subcortical structures such as the brainstem and the cerebellum alters levels of CRH in CSF. Together with the recent anatomical and physiological evidence, the results suggest pathophysiological relevance of CRH for the cerebellar symptoms in SCD.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>7475976</pmid><doi>10.1016/0024-3205(95)02215-5</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Aged Alzheimer Disease - cerebrospinal fluid Alzheimer' s disease cerebrospinal fluid corticotropin-releasing hormone Corticotropin-Releasing Hormone - cerebrospinal fluid Dementia DRPLA Friedreich Ataxia - cerebrospinal fluid Friedreich' s ataxia Humans Middle Aged Nervous System Diseases - cerebrospinal fluid OPCA Parkinson Disease - cerebrospinal fluid Parkinson' s disease senile dementia spinocerebellar degeneration Spinocerebellar Degenerations - cerebrospinal fluid |
| title | Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: Reduction in spinocerebellar degeneration |
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