Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies
Rats were treated orally with gossypol acetic acid at 30 or 10 mg/kg daily, 6 days a week, for 8, 12, 14 or 16 weeks. At the end of each treatment regimen, treated rats and an equal number of control rats were killed for histological and histochemical studies. From 8 weeks onward, as a result of the...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 1987-06, Vol.20 (1), p.39-43 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 43 |
|---|---|
| container_issue | 1 |
| container_start_page | 39 |
| container_title | Journal of ethnopharmacology |
| container_volume | 20 |
| creator | Zhou, L.F Qi, S.Q Lei, H.P |
| description | Rats were treated orally with gossypol acetic acid at 30 or 10 mg/kg daily, 6 days a week, for 8, 12, 14 or 16 weeks. At the end of each treatment regimen, treated rats and an equal number of control rats were killed for histological and histochemical studies. From 8 weeks onward, as a result of the treatment, the tubular lumen of the corpus epididymides became narrowed with thickened pseudostratified epithelium and there was a reduction in the amount of spermatozoa. There was an increase in esterase, alkaline phosphatase, acid phosphatase and ATPase activity. These changes increased in intensity with the duration of treatment. Scanning electron microscopic examinations of the corpus epididymides of rats treated for 16 weeks, compared with those of controls, revealed similar changes, namely, narrowing of the tubular lumen, thickening of the pseudostratified epithelium and reduction in the number of spermatozoa. |
| doi_str_mv | 10.1016/0378-8741(87)90117-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77688344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0378874187901176</els_id><sourcerecordid>77688344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-8dbe3d6a425ebe7e71520c3f8fe0215efb4f8ca9cf49be9e524db498a31967123</originalsourceid><addsrcrecordid>eNp9kMFuEzEQhi0EKmnhDUD4gBAcFjy2d-3tAQlVhSJV4gA9W157nBht1ou9Qcrb4zRRjlw8h_-b0e-PkFfAPgKD7hMTSjdaSXiv1YeeAaime0JWoBVvVKvEU7I6I8_JZSm_GWMKJLsgF4JJAM5XZHMbArqFpkDXqZT9nEZqHS7R1RE9TRNdNkhxjj76_TaWa3oXy5LcBrfR2QpPnhZnpylOa4pjvZXrTs1yKi7NSMuy8xHLC_Is2LHgy9O8Ig9fb3_d3DX3P759v_ly3zgJbGm0H1D4zkre4oAKFbScORF0QMahxTDIoJ3tXZD9gD22XPpB9toK6DsFXFyRd8e7c05_dlgWU0s7HEc7YdoVo1SntZCygvIIHpqWjMHMOW5t3htg5iDYHOyZg736mEfBpqtrr0_3d8MW_XnpZLTmb0-5rVrGkO3kYjljmveKy75ib45YsMnYda7Iw0_OQDCQon6DVeLzkcBq62_EbIqLODn0MVfLxqf4_6b_APcyoXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77688344</pqid></control><display><type>article</type><title>Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Zhou, L.F ; Qi, S.Q ; Lei, H.P</creator><creatorcontrib>Zhou, L.F ; Qi, S.Q ; Lei, H.P</creatorcontrib><description>Rats were treated orally with gossypol acetic acid at 30 or 10 mg/kg daily, 6 days a week, for 8, 12, 14 or 16 weeks. At the end of each treatment regimen, treated rats and an equal number of control rats were killed for histological and histochemical studies. From 8 weeks onward, as a result of the treatment, the tubular lumen of the corpus epididymides became narrowed with thickened pseudostratified epithelium and there was a reduction in the amount of spermatozoa. There was an increase in esterase, alkaline phosphatase, acid phosphatase and ATPase activity. These changes increased in intensity with the duration of treatment. Scanning electron microscopic examinations of the corpus epididymides of rats treated for 16 weeks, compared with those of controls, revealed similar changes, namely, narrowing of the tubular lumen, thickening of the pseudostratified epithelium and reduction in the number of spermatozoa.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/0378-8741(87)90117-6</identifier><identifier>PMID: 3041122</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>acetic acid ; Animals ; Biological and medical sciences ; Birth control ; epididymis ; Epididymis - drug effects ; Epididymis - metabolism ; Epididymis - ultrastructure ; Esterases - metabolism ; Glycogen - metabolism ; gossypol ; Gossypol - analogs & derivatives ; Gossypol - pharmacology ; Gynecology. Andrology. Obstetrics ; histochemistry ; Male ; Medical sciences ; Microscopy, Electron ; Other methods of contraception. Sterilization ; Phosphoric Monoester Hydrolases - metabolism ; Rats ; Rats, Inbred Strains ; scanning electron microscopy ; Succinate Dehydrogenase - metabolism</subject><ispartof>Journal of ethnopharmacology, 1987-06, Vol.20 (1), p.39-43</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-8dbe3d6a425ebe7e71520c3f8fe0215efb4f8ca9cf49be9e524db498a31967123</citedby><cites>FETCH-LOGICAL-c410t-8dbe3d6a425ebe7e71520c3f8fe0215efb4f8ca9cf49be9e524db498a31967123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-8741(87)90117-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8297249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3041122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, L.F</creatorcontrib><creatorcontrib>Qi, S.Q</creatorcontrib><creatorcontrib>Lei, H.P</creatorcontrib><title>Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Rats were treated orally with gossypol acetic acid at 30 or 10 mg/kg daily, 6 days a week, for 8, 12, 14 or 16 weeks. At the end of each treatment regimen, treated rats and an equal number of control rats were killed for histological and histochemical studies. From 8 weeks onward, as a result of the treatment, the tubular lumen of the corpus epididymides became narrowed with thickened pseudostratified epithelium and there was a reduction in the amount of spermatozoa. There was an increase in esterase, alkaline phosphatase, acid phosphatase and ATPase activity. These changes increased in intensity with the duration of treatment. Scanning electron microscopic examinations of the corpus epididymides of rats treated for 16 weeks, compared with those of controls, revealed similar changes, namely, narrowing of the tubular lumen, thickening of the pseudostratified epithelium and reduction in the number of spermatozoa.</description><subject>acetic acid</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>epididymis</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - metabolism</subject><subject>Epididymis - ultrastructure</subject><subject>Esterases - metabolism</subject><subject>Glycogen - metabolism</subject><subject>gossypol</subject><subject>Gossypol - analogs & derivatives</subject><subject>Gossypol - pharmacology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>histochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Other methods of contraception. Sterilization</subject><subject>Phosphoric Monoester Hydrolases - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>scanning electron microscopy</subject><subject>Succinate Dehydrogenase - metabolism</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFuEzEQhi0EKmnhDUD4gBAcFjy2d-3tAQlVhSJV4gA9W157nBht1ou9Qcrb4zRRjlw8h_-b0e-PkFfAPgKD7hMTSjdaSXiv1YeeAaime0JWoBVvVKvEU7I6I8_JZSm_GWMKJLsgF4JJAM5XZHMbArqFpkDXqZT9nEZqHS7R1RE9TRNdNkhxjj76_TaWa3oXy5LcBrfR2QpPnhZnpylOa4pjvZXrTs1yKi7NSMuy8xHLC_Is2LHgy9O8Ig9fb3_d3DX3P759v_ly3zgJbGm0H1D4zkre4oAKFbScORF0QMahxTDIoJ3tXZD9gD22XPpB9toK6DsFXFyRd8e7c05_dlgWU0s7HEc7YdoVo1SntZCygvIIHpqWjMHMOW5t3htg5iDYHOyZg736mEfBpqtrr0_3d8MW_XnpZLTmb0-5rVrGkO3kYjljmveKy75ib45YsMnYda7Iw0_OQDCQon6DVeLzkcBq62_EbIqLODn0MVfLxqf4_6b_APcyoXw</recordid><startdate>19870601</startdate><enddate>19870601</enddate><creator>Zhou, L.F</creator><creator>Qi, S.Q</creator><creator>Lei, H.P</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870601</creationdate><title>Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies</title><author>Zhou, L.F ; Qi, S.Q ; Lei, H.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-8dbe3d6a425ebe7e71520c3f8fe0215efb4f8ca9cf49be9e524db498a31967123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>acetic acid</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>epididymis</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - metabolism</topic><topic>Epididymis - ultrastructure</topic><topic>Esterases - metabolism</topic><topic>Glycogen - metabolism</topic><topic>gossypol</topic><topic>Gossypol - analogs & derivatives</topic><topic>Gossypol - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>histochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Other methods of contraception. Sterilization</topic><topic>Phosphoric Monoester Hydrolases - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>scanning electron microscopy</topic><topic>Succinate Dehydrogenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, L.F</creatorcontrib><creatorcontrib>Qi, S.Q</creatorcontrib><creatorcontrib>Lei, H.P</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, L.F</au><au>Qi, S.Q</au><au>Lei, H.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1987-06-01</date><risdate>1987</risdate><volume>20</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Rats were treated orally with gossypol acetic acid at 30 or 10 mg/kg daily, 6 days a week, for 8, 12, 14 or 16 weeks. At the end of each treatment regimen, treated rats and an equal number of control rats were killed for histological and histochemical studies. From 8 weeks onward, as a result of the treatment, the tubular lumen of the corpus epididymides became narrowed with thickened pseudostratified epithelium and there was a reduction in the amount of spermatozoa. There was an increase in esterase, alkaline phosphatase, acid phosphatase and ATPase activity. These changes increased in intensity with the duration of treatment. Scanning electron microscopic examinations of the corpus epididymides of rats treated for 16 weeks, compared with those of controls, revealed similar changes, namely, narrowing of the tubular lumen, thickening of the pseudostratified epithelium and reduction in the number of spermatozoa.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3041122</pmid><doi>10.1016/0378-8741(87)90117-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 1987-06, Vol.20 (1), p.39-43 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77688344 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | acetic acid Animals Biological and medical sciences Birth control epididymis Epididymis - drug effects Epididymis - metabolism Epididymis - ultrastructure Esterases - metabolism Glycogen - metabolism gossypol Gossypol - analogs & derivatives Gossypol - pharmacology Gynecology. Andrology. Obstetrics histochemistry Male Medical sciences Microscopy, Electron Other methods of contraception. Sterilization Phosphoric Monoester Hydrolases - metabolism Rats Rats, Inbred Strains scanning electron microscopy Succinate Dehydrogenase - metabolism |
| title | Effect of gossypol acetic acid on the epididymis: Histochemical and scanning electron microscope studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T22%3A24%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20gossypol%20acetic%20acid%20on%20the%20epididymis:%20Histochemical%20and%20scanning%20electron%20microscope%20studies&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Zhou,%20L.F&rft.date=1987-06-01&rft.volume=20&rft.issue=1&rft.spage=39&rft.epage=43&rft.pages=39-43&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/0378-8741(87)90117-6&rft_dat=%3Cproquest_cross%3E77688344%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77688344&rft_id=info:pmid/3041122&rft_els_id=0378874187901176&rfr_iscdi=true |