A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain
In this study, the effects of a single dose of the indirect dopamine agonists amphetamine and methamphetamine on behavior and messenger RNA expression were evaluated. Expression of c- fos, a member of the leucine zipper family, zif/268 (NGFI-A, egrl and Krox-24), a member of the zinc finger family,...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 1995-09, Vol.68 (1), p.83-95 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 95 |
|---|---|
| container_issue | 1 |
| container_start_page | 83 |
| container_title | Neuroscience |
| container_volume | 68 |
| creator | Wang, J.Q. Smith, A.J.W. McGinty, J.F. |
| description | In this study, the effects of a single dose of the indirect dopamine agonists amphetamine and methamphetamine on behavior and messenger RNA expression were evaluated. Expression of c-
fos, a member of the leucine zipper family,
zif/268 (NGFI-A, egrl and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative
in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection. Behavioral observations indicated that a qualitatively different behavioral syndrome was induced following methamphetamine (15 mg/kg, i.p.) as compared with that observed after amphetamine (5 mg/kg, i.p.). Similarly, methamphetamine induced a different pattern of c-
fos and
zif/268 messenger RNA induction in sensory/motor cortex, dorsal striatum (caudatoputamen) and ventral striatum (nucleus accumbens) than did amphetamine. The increase in c-
fos messenger RNA expression peaked at 1 h and returned to basal levels in all regions by 3 h. In contrast, the increase in
zif/268 messenger RNA expression in the cortical regions was equally strong at 1 and 2 h, gradually returning to basal levels by 6 h after either drug. However, in the striatal regions,
zif/268 messenger RNA levels peaked at 1 h and declined gradually to basal levels by 6 h. Interestingly, methamphetamine caused an actual suppression of
zif/268 gene expression (> 50%) in both caudatoputamen and nucleus accumbens at 3 h. Preprodynorphin messenger RNA expression was increased in a patchy motif in the caudatoputamen and nucleus accumbens beginning at 2 h and returning to basal levels by 30 h after injection of either drug. This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-
fos,
zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine. |
| doi_str_mv | 10.1016/0306-4522(95)00100-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77685308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030645229500100W</els_id><sourcerecordid>77685308</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-49064bdf9144f78e8d6531ed7461b4dc1b2ed8a8de1a9e1da364a4563ac5dc423</originalsourceid><addsrcrecordid>eNqFkV1rFDEYhYModVv9Bwq5kKLg2GTyOTfCUuoHFAVRehkyyTvdlJnMmMwW67_xn5pxl8WrNjeBnOecvMlB6AUl7yih8owwIisu6vp1I94QQgmprh6hFdWKVUpw_hitDshTdJzzDSlLcHaEjhRXqmF6hf6scQ7xugcc4g24OYwRjx22w7SB2Q4hAh4THmDe_H8Uot86yNjfxXLgsO1nSHYx56JhV-FuzG_x79Cd1VJjGz2eEkxpLIYxTZvCDJAzxGtI-NuXNYZfRc95ub1oJaoEJGiTDfEZetLZPsPz_X6Cfny4-H7-qbr8-vHz-fqycpyqueINkbz1XUM575QG7aVgFLzikrbcO9rW4LXVHqhtgHrLJLdcSGad8I7X7ASd7nLLmD-3kGczhOyg722EcZuNUlILRvSDIJVaCqoWkO9Al8acE3RmSmGw6c5QYpYKzdKPWfoxjTD_KjRXxfZyn79tB_AH076zor_a6zY723fJRhfyAWOiUM3ynvc7DMqn3QZIJrsA0YEPqRRt_Bjun-Mv-tu6Zw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16865178</pqid></control><display><type>article</type><title>A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wang, J.Q. ; Smith, A.J.W. ; McGinty, J.F.</creator><creatorcontrib>Wang, J.Q. ; Smith, A.J.W. ; McGinty, J.F.</creatorcontrib><description>In this study, the effects of a single dose of the indirect dopamine agonists amphetamine and methamphetamine on behavior and messenger RNA expression were evaluated. Expression of c-
fos, a member of the leucine zipper family,
zif/268 (NGFI-A, egrl and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative
in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection. Behavioral observations indicated that a qualitatively different behavioral syndrome was induced following methamphetamine (15 mg/kg, i.p.) as compared with that observed after amphetamine (5 mg/kg, i.p.). Similarly, methamphetamine induced a different pattern of c-
fos and
zif/268 messenger RNA induction in sensory/motor cortex, dorsal striatum (caudatoputamen) and ventral striatum (nucleus accumbens) than did amphetamine. The increase in c-
fos messenger RNA expression peaked at 1 h and returned to basal levels in all regions by 3 h. In contrast, the increase in
zif/268 messenger RNA expression in the cortical regions was equally strong at 1 and 2 h, gradually returning to basal levels by 6 h after either drug. However, in the striatal regions,
zif/268 messenger RNA levels peaked at 1 h and declined gradually to basal levels by 6 h. Interestingly, methamphetamine caused an actual suppression of
zif/268 gene expression (> 50%) in both caudatoputamen and nucleus accumbens at 3 h. Preprodynorphin messenger RNA expression was increased in a patchy motif in the caudatoputamen and nucleus accumbens beginning at 2 h and returning to basal levels by 30 h after injection of either drug. This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-
fos,
zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(95)00100-W</identifier><identifier>PMID: 7477938</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amphetamine - pharmacology ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Central Nervous System Stimulants - pharmacology ; DNA-Binding Proteins - biosynthesis ; Dynorphins - biosynthesis ; Early Growth Response Protein 1 ; Gene Expression Regulation - drug effects ; Genes, fos - drug effects ; Genes, Immediate-Early - drug effects ; Immediate-Early Proteins ; In Situ Hybridization ; Male ; Medical sciences ; Methamphetamine - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Prosencephalon - drug effects ; Prosencephalon - metabolism ; Protein Precursors - biosynthesis ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; RNA, Messenger - biosynthesis ; Transcription Factors - biosynthesis ; Zinc Fingers</subject><ispartof>Neuroscience, 1995-09, Vol.68 (1), p.83-95</ispartof><rights>1995 IBRO</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-49064bdf9144f78e8d6531ed7461b4dc1b2ed8a8de1a9e1da364a4563ac5dc423</citedby><cites>FETCH-LOGICAL-c417t-49064bdf9144f78e8d6531ed7461b4dc1b2ed8a8de1a9e1da364a4563ac5dc423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030645229500100W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3579392$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7477938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J.Q.</creatorcontrib><creatorcontrib>Smith, A.J.W.</creatorcontrib><creatorcontrib>McGinty, J.F.</creatorcontrib><title>A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>In this study, the effects of a single dose of the indirect dopamine agonists amphetamine and methamphetamine on behavior and messenger RNA expression were evaluated. Expression of c-
fos, a member of the leucine zipper family,
zif/268 (NGFI-A, egrl and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative
in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection. Behavioral observations indicated that a qualitatively different behavioral syndrome was induced following methamphetamine (15 mg/kg, i.p.) as compared with that observed after amphetamine (5 mg/kg, i.p.). Similarly, methamphetamine induced a different pattern of c-
fos and
zif/268 messenger RNA induction in sensory/motor cortex, dorsal striatum (caudatoputamen) and ventral striatum (nucleus accumbens) than did amphetamine. The increase in c-
fos messenger RNA expression peaked at 1 h and returned to basal levels in all regions by 3 h. In contrast, the increase in
zif/268 messenger RNA expression in the cortical regions was equally strong at 1 and 2 h, gradually returning to basal levels by 6 h after either drug. However, in the striatal regions,
zif/268 messenger RNA levels peaked at 1 h and declined gradually to basal levels by 6 h. Interestingly, methamphetamine caused an actual suppression of
zif/268 gene expression (> 50%) in both caudatoputamen and nucleus accumbens at 3 h. Preprodynorphin messenger RNA expression was increased in a patchy motif in the caudatoputamen and nucleus accumbens beginning at 2 h and returning to basal levels by 30 h after injection of either drug. This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-
fos,
zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine.</description><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>Dynorphins - biosynthesis</subject><subject>Early Growth Response Protein 1</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, fos - drug effects</subject><subject>Genes, Immediate-Early - drug effects</subject><subject>Immediate-Early Proteins</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methamphetamine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prosencephalon - drug effects</subject><subject>Prosencephalon - metabolism</subject><subject>Protein Precursors - biosynthesis</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transcription Factors - biosynthesis</subject><subject>Zinc Fingers</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEYhYModVv9Bwq5kKLg2GTyOTfCUuoHFAVRehkyyTvdlJnMmMwW67_xn5pxl8WrNjeBnOecvMlB6AUl7yih8owwIisu6vp1I94QQgmprh6hFdWKVUpw_hitDshTdJzzDSlLcHaEjhRXqmF6hf6scQ7xugcc4g24OYwRjx22w7SB2Q4hAh4THmDe_H8Uot86yNjfxXLgsO1nSHYx56JhV-FuzG_x79Cd1VJjGz2eEkxpLIYxTZvCDJAzxGtI-NuXNYZfRc95ub1oJaoEJGiTDfEZetLZPsPz_X6Cfny4-H7-qbr8-vHz-fqycpyqueINkbz1XUM575QG7aVgFLzikrbcO9rW4LXVHqhtgHrLJLdcSGad8I7X7ASd7nLLmD-3kGczhOyg722EcZuNUlILRvSDIJVaCqoWkO9Al8acE3RmSmGw6c5QYpYKzdKPWfoxjTD_KjRXxfZyn79tB_AH076zor_a6zY723fJRhfyAWOiUM3ynvc7DMqn3QZIJrsA0YEPqRRt_Bjun-Mv-tu6Zw</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Wang, J.Q.</creator><creator>Smith, A.J.W.</creator><creator>McGinty, J.F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain</title><author>Wang, J.Q. ; Smith, A.J.W. ; McGinty, J.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-49064bdf9144f78e8d6531ed7461b4dc1b2ed8a8de1a9e1da364a4563ac5dc423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>Dynorphins - biosynthesis</topic><topic>Early Growth Response Protein 1</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes, fos - drug effects</topic><topic>Genes, Immediate-Early - drug effects</topic><topic>Immediate-Early Proteins</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methamphetamine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prosencephalon - drug effects</topic><topic>Prosencephalon - metabolism</topic><topic>Protein Precursors - biosynthesis</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transcription Factors - biosynthesis</topic><topic>Zinc Fingers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J.Q.</creatorcontrib><creatorcontrib>Smith, A.J.W.</creatorcontrib><creatorcontrib>McGinty, J.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J.Q.</au><au>Smith, A.J.W.</au><au>McGinty, J.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>68</volume><issue>1</issue><spage>83</spage><epage>95</epage><pages>83-95</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>In this study, the effects of a single dose of the indirect dopamine agonists amphetamine and methamphetamine on behavior and messenger RNA expression were evaluated. Expression of c-
fos, a member of the leucine zipper family,
zif/268 (NGFI-A, egrl and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative
in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection. Behavioral observations indicated that a qualitatively different behavioral syndrome was induced following methamphetamine (15 mg/kg, i.p.) as compared with that observed after amphetamine (5 mg/kg, i.p.). Similarly, methamphetamine induced a different pattern of c-
fos and
zif/268 messenger RNA induction in sensory/motor cortex, dorsal striatum (caudatoputamen) and ventral striatum (nucleus accumbens) than did amphetamine. The increase in c-
fos messenger RNA expression peaked at 1 h and returned to basal levels in all regions by 3 h. In contrast, the increase in
zif/268 messenger RNA expression in the cortical regions was equally strong at 1 and 2 h, gradually returning to basal levels by 6 h after either drug. However, in the striatal regions,
zif/268 messenger RNA levels peaked at 1 h and declined gradually to basal levels by 6 h. Interestingly, methamphetamine caused an actual suppression of
zif/268 gene expression (> 50%) in both caudatoputamen and nucleus accumbens at 3 h. Preprodynorphin messenger RNA expression was increased in a patchy motif in the caudatoputamen and nucleus accumbens beginning at 2 h and returning to basal levels by 30 h after injection of either drug. This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-
fos,
zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7477938</pmid><doi>10.1016/0306-4522(95)00100-W</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 1995-09, Vol.68 (1), p.83-95 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77685308 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amphetamine - pharmacology Animals Behavior, Animal - drug effects Biological and medical sciences Central Nervous System Stimulants - pharmacology DNA-Binding Proteins - biosynthesis Dynorphins - biosynthesis Early Growth Response Protein 1 Gene Expression Regulation - drug effects Genes, fos - drug effects Genes, Immediate-Early - drug effects Immediate-Early Proteins In Situ Hybridization Male Medical sciences Methamphetamine - pharmacology Neuropharmacology Pharmacology. Drug treatments Prosencephalon - drug effects Prosencephalon - metabolism Protein Precursors - biosynthesis Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar RNA, Messenger - biosynthesis Transcription Factors - biosynthesis Zinc Fingers |
| title | A single injection of amphetamine or methamphetamine induces dynamic alterations in c- fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T19%3A34%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20single%20injection%20of%20amphetamine%20or%20methamphetamine%20induces%20dynamic%20alterations%20in%20c-%20fos,%20zif/268%20and%20preprodynorphin%20messenger%20RNA%20expression%20in%20rat%20forebrain&rft.jtitle=Neuroscience&rft.au=Wang,%20J.Q.&rft.date=1995-09-01&rft.volume=68&rft.issue=1&rft.spage=83&rft.epage=95&rft.pages=83-95&rft.issn=0306-4522&rft.eissn=1873-7544&rft.coden=NRSCDN&rft_id=info:doi/10.1016/0306-4522(95)00100-W&rft_dat=%3Cproquest_cross%3E77685308%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16865178&rft_id=info:pmid/7477938&rft_els_id=030645229500100W&rfr_iscdi=true |