Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells

Exposure of NIH3T3 cells to elevated temperatures induces the phosphorylation and activation of mitogen-activated protein (MAP) kinases [or extracellular signal-regulated kinases (ERKs)]. To investigate the significance of MAP kinase activation by heat shock, we examined the effect of inhibiting the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-12, Vol.55 (23), p.5512-5519
Hauptverfasser:	MIVECHI, N. F, GIACCIA, A. J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium-Calmodulin-Dependent Protein Kinases - physiology DNA-Binding Proteins - metabolism Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, ras Heat Shock Transcription Factors Hot Temperature HSP70 Heat-Shock Proteins - metabolism Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Molecular Sequence Data Phosphorylation - drug effects Transcription Factors Transferases Vanadates - pharmacology
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