Pharmacological Analysis in Rat of the Role of the ATP-Sensitive Potassium Channel as a Potential Target for Antifibrillatory Intervention in Acute Myocardial Ischaemia

We tested the hypothesis that blockade of the ATP-sensitive K channel (IK(ATP)) is an antiarrhythmic mechanism in acute myocardial ischaemia, using an opener of the channel (10μM RP 49356, RP) and a blocker of the channel (10 μM glibenclamide, GL) and a combination of the two drugs (GL + RP, 10 μM e...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1995-08, Vol.26 (2), p.280-288
Hauptverfasser:	Rees, Sian A, Curtis, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Biological and medical sciences Cardiovascular system Coronary Circulation - drug effects Electrocardiography - drug effects Glyburide - pharmacology Male Medical sciences Myocardial Ischemia - physiopathology Pharmacology. Drug treatments Picolines - pharmacology Potassium Channels - drug effects Potassium Channels - physiology Pyrans - pharmacology Rats Rats, Wistar Ventricular Fibrillation - drug therapy
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