Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta
The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth Factor-$\beta $ (TGF-$\beta $), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a si...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1987-09, Vol.237 (4820), p.1333-1336 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Mustoe, Thomas A. Pierce, Glenn F. Thomason, Arlen Gramates, Peggy Sporn, Michael B. Deuel, Thomas F. |
| description | The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth Factor-$\beta $ (TGF-$\beta $), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-$\beta $ on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-$\beta $ These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-$\beta $. TGF-$\beta $ is thus a potent pharmacologic agent that can accelerate wound healing in rats. |
| doi_str_mv | 10.1126/science.2442813 |
| format | Article |
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A dose-dependent, direct stimulatory effect of a single application of TGF-$\beta $ on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-$\beta $ These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-$\beta $. TGF-$\beta $ is thus a potent pharmacologic agent that can accelerate wound healing in rats.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2442813</identifier><identifier>PMID: 2442813</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animals ; Biochemistry ; Biological and medical sciences ; Collagens ; Fibroblasts ; Flux density ; Growth factors ; Growth Substances - pharmacology ; Healing ; Histology ; Hormones ; Inflammation ; Infrared observatories ; Injuries ; Laboratory rats ; Male ; Medical research ; Medical sciences ; Peptides - pharmacology ; Pharmacology. Drug treatments ; Physical growth ; Physiological aspects ; Platelet-derived growth factor ; Platelets ; Pluto ; Rats ; Rats as laboratory animals ; Rats, Inbred Strains ; Regeneration (Biology) ; Rodents ; Skin, nail, hair, dermoskeleton ; Staining and Labeling ; Transforming Growth Factors ; Wound healing ; Wound Healing - drug effects ; Wounds and injuries ; Wounds, Penetrating - pathology</subject><ispartof>Science (American Association for the Advancement of Science), 1987-09, Vol.237 (4820), p.1333-1336</ispartof><rights>Copyright 1987 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 11, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-5c7d9588d1f69aeb19f80d0e0e6e3e02278e5c70547a45b8aa21ea73036478cb3</citedby><cites>FETCH-LOGICAL-c699t-5c7d9588d1f69aeb19f80d0e0e6e3e02278e5c70547a45b8aa21ea73036478cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1700007$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1700007$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7783004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2442813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mustoe, Thomas A.</creatorcontrib><creatorcontrib>Pierce, Glenn F.</creatorcontrib><creatorcontrib>Thomason, Arlen</creatorcontrib><creatorcontrib>Gramates, Peggy</creatorcontrib><creatorcontrib>Sporn, Michael B.</creatorcontrib><creatorcontrib>Deuel, Thomas F.</creatorcontrib><title>Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth Factor-$\beta $ (TGF-$\beta $), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-$\beta $ on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-$\beta $ These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-$\beta $. TGF-$\beta $ is thus a potent pharmacologic agent that can accelerate wound healing in rats.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Collagens</subject><subject>Fibroblasts</subject><subject>Flux density</subject><subject>Growth factors</subject><subject>Growth Substances - pharmacology</subject><subject>Healing</subject><subject>Histology</subject><subject>Hormones</subject><subject>Inflammation</subject><subject>Infrared observatories</subject><subject>Injuries</subject><subject>Laboratory rats</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Peptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical growth</subject><subject>Physiological aspects</subject><subject>Platelet-derived growth factor</subject><subject>Platelets</subject><subject>Pluto</subject><subject>Rats</subject><subject>Rats as laboratory animals</subject><subject>Rats, Inbred Strains</subject><subject>Regeneration (Biology)</subject><subject>Rodents</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Staining and Labeling</subject><subject>Transforming Growth Factors</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and injuries</subject><subject>Wounds, Penetrating - pathology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0-9r1DAYB_Aiyjynr32jUMbQF1u3_Gib5OV5uNvB4YFOfaOENH1ae7TJTFp0_705rmxzHOzIi0CeTxKSfBNFrzE6w5jk5143YDSckTQlHNMn0QQjkSWCIPo0miBE84Qjlj2PXni_RijUBD2IDkY-iX5OtYYWnOqhjC9BtY2pY1vFC6Mb31ij2vi7HUzp48bEn1XvQ6UcdMDFTXzllPGVdd1m0tzZP_2v-ELp3rrk-EcBvXoZPatU6-HV2B9GXy8-Xs0uk-VqvphNl4nOheiTTLNSZJyXuMqFggKLiqMSAYIcKCBCGIdgUJYylWYFV4pgUIyG06WM64IeRu-26147-3sA38uu8eFcrTJgBy8ZyznhFD8KaYZEijh9FOKUpTQXLMCjB3BtBxfuzUuCaUYYSzfoZItq1YJsTGV7p3QNJlx8aw1UTRieZgTnFKOgT3fo0EroGr2Dv_-PB9HD375Wg_dy8eXTvnL1bV_5Yb6n5PPlfXmyS2rbtlCDDIGYre7r863WznrvoJLXrumUu5EYyU305Rh9OWY5zHg7vsRQdFDe-rv68VhXXqu2CuENGb9ljHGKUBrYmy1b-xDku11Z-D2I0X-GDhAo</recordid><startdate>19870911</startdate><enddate>19870911</enddate><creator>Mustoe, Thomas A.</creator><creator>Pierce, Glenn F.</creator><creator>Thomason, Arlen</creator><creator>Gramates, Peggy</creator><creator>Sporn, Michael B.</creator><creator>Deuel, Thomas F.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19870911</creationdate><title>Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta</title><author>Mustoe, Thomas A. ; Pierce, Glenn F. ; Thomason, Arlen ; Gramates, Peggy ; Sporn, Michael B. ; Deuel, Thomas F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c699t-5c7d9588d1f69aeb19f80d0e0e6e3e02278e5c70547a45b8aa21ea73036478cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Collagens</topic><topic>Fibroblasts</topic><topic>Flux density</topic><topic>Growth factors</topic><topic>Growth Substances - pharmacology</topic><topic>Healing</topic><topic>Histology</topic><topic>Hormones</topic><topic>Inflammation</topic><topic>Infrared observatories</topic><topic>Injuries</topic><topic>Laboratory rats</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Peptides - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical growth</topic><topic>Physiological aspects</topic><topic>Platelet-derived growth factor</topic><topic>Platelets</topic><topic>Pluto</topic><topic>Rats</topic><topic>Rats as laboratory animals</topic><topic>Rats, Inbred Strains</topic><topic>Regeneration (Biology)</topic><topic>Rodents</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Staining and Labeling</topic><topic>Transforming Growth Factors</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and injuries</topic><topic>Wounds, Penetrating - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mustoe, Thomas A.</creatorcontrib><creatorcontrib>Pierce, Glenn F.</creatorcontrib><creatorcontrib>Thomason, Arlen</creatorcontrib><creatorcontrib>Gramates, Peggy</creatorcontrib><creatorcontrib>Sporn, Michael B.</creatorcontrib><creatorcontrib>Deuel, Thomas F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mustoe, Thomas A.</au><au>Pierce, Glenn F.</au><au>Thomason, Arlen</au><au>Gramates, Peggy</au><au>Sporn, Michael B.</au><au>Deuel, Thomas F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1987-09-11</date><risdate>1987</risdate><volume>237</volume><issue>4820</issue><spage>1333</spage><epage>1336</epage><pages>1333-1336</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth Factor-$\beta $ (TGF-$\beta $), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-$\beta $ on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-$\beta $ These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-$\beta $. TGF-$\beta $ is thus a potent pharmacologic agent that can accelerate wound healing in rats.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2442813</pmid><doi>10.1126/science.2442813</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1987-09, Vol.237 (4820), p.1333-1336 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77682831 |
| source | MEDLINE; Jstor Complete Legacy; Science journals (American Association for the Advancement of Science = AAAS) |
| subjects | Animals Biochemistry Biological and medical sciences Collagens Fibroblasts Flux density Growth factors Growth Substances - pharmacology Healing Histology Hormones Inflammation Infrared observatories Injuries Laboratory rats Male Medical research Medical sciences Peptides - pharmacology Pharmacology. Drug treatments Physical growth Physiological aspects Platelet-derived growth factor Platelets Pluto Rats Rats as laboratory animals Rats, Inbred Strains Regeneration (Biology) Rodents Skin, nail, hair, dermoskeleton Staining and Labeling Transforming Growth Factors Wound healing Wound Healing - drug effects Wounds and injuries Wounds, Penetrating - pathology |
| title | Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta |
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