HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? a preliminary study
This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis. Pancreatic specimens from 12 chronic pancreatitis patients and nine controls were examined. Strong HLA-DR expression was observed in...
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| Veröffentlicht in: | Pancreas 1987-01, Vol.2 (3), p.350-356 |
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| container_title | Pancreas |
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| creator | BOVO, P MIRAKIAN, R MERIGO, F ANGELINI, G CAVALLINI, G RIZZINI, P BOTTAZZO, G. F SCURO, L. A |
| description | This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis. Pancreatic specimens from 12 chronic pancreatitis patients and nine controls were examined. Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls. Moreover, lymphocytic foci with large numbers of activated cells were found only in chronic pancreatitis. The four HLA-DR - patients had a marked increase of fibrous tissue with small portions of acinar tissue, whereas the six patients with strong positivity had the greatest dilatation and hyperplasia of the ducts. These findings are similar to those observed in immune diseases, such as thyroiditis and primary biliary cirrhosis (PBC), and suggest that autoimmune phenomena are involved in chronic pancreatitis. |
| doi_str_mv | 10.1097/00006676-198705000-00016 |
| format | Article |
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F ; SCURO, L. A</creator><creatorcontrib>BOVO, P ; MIRAKIAN, R ; MERIGO, F ; ANGELINI, G ; CAVALLINI, G ; RIZZINI, P ; BOTTAZZO, G. F ; SCURO, L. A</creatorcontrib><description>This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis. Pancreatic specimens from 12 chronic pancreatitis patients and nine controls were examined. Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls. Moreover, lymphocytic foci with large numbers of activated cells were found only in chronic pancreatitis. The four HLA-DR - patients had a marked increase of fibrous tissue with small portions of acinar tissue, whereas the six patients with strong positivity had the greatest dilatation and hyperplasia of the ducts. These findings are similar to those observed in immune diseases, such as thyroiditis and primary biliary cirrhosis (PBC), and suggest that autoimmune phenomena are involved in chronic pancreatitis.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-198705000-00016</identifier><identifier>PMID: 3498162</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Chronic Disease ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; HLA Antigens ; HLA-D Antigens ; HLA-DR Antigens ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphocyte Activation ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pancreatitis - immunology ; Pancreatitis - pathology ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology</subject><ispartof>Pancreas, 1987-01, Vol.2 (3), p.350-356</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8324069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3498162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOVO, P</creatorcontrib><creatorcontrib>MIRAKIAN, R</creatorcontrib><creatorcontrib>MERIGO, F</creatorcontrib><creatorcontrib>ANGELINI, G</creatorcontrib><creatorcontrib>CAVALLINI, G</creatorcontrib><creatorcontrib>RIZZINI, P</creatorcontrib><creatorcontrib>BOTTAZZO, G. F</creatorcontrib><creatorcontrib>SCURO, L. A</creatorcontrib><title>HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? a preliminary study</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis. Pancreatic specimens from 12 chronic pancreatitis patients and nine controls were examined. Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls. Moreover, lymphocytic foci with large numbers of activated cells were found only in chronic pancreatitis. The four HLA-DR - patients had a marked increase of fibrous tissue with small portions of acinar tissue, whereas the six patients with strong positivity had the greatest dilatation and hyperplasia of the ducts. These findings are similar to those observed in immune diseases, such as thyroiditis and primary biliary cirrhosis (PBC), and suggest that autoimmune phenomena are involved in chronic pancreatitis.</description><subject>Adult</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>HLA Antigens</subject><subject>HLA-D Antigens</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis - immunology</subject><subject>Pancreatitis - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLAzEQhYMotVZ_gpAH8W11s7muL1KKWqHgiz4vaXZCI3szyYL990a7NiQMwzlzMnwIYZLfkbyU93k6QkiRkVLJnKcuS4-IEzQnnIqMqUKdonmuFM8okfIcXYTwmRyS8nKGZpSViohijob1ZonbvgEzNoDhe_AQgus7nK7Z-b5zBg-6Mx50dNEFHAYwroUuPODUxR14wBr7lIBt77EeY-_aduxc3D8mIeU1rnWd9nsc4ljvL9GZ1U2Aq6ku0Mfz0_tqnW3eXl5Xy01mCsViJtOmTEANpNgyXaiyBiOBc1pLZUttGTHcKlvresuFKCxhmpecWitFoa2idIFuD7mD779GCLFqXTDQNLqDfgyVlCIRYHkyqoPR-D4ED7YavGvTvhXJq1_Y1T_s6gi7-oOdRq-nP8ZtC_VxcKKb9JtJ18HoxvoE0oWjTdGC5aKkP3skiQc</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>BOVO, P</creator><creator>MIRAKIAN, R</creator><creator>MERIGO, F</creator><creator>ANGELINI, G</creator><creator>CAVALLINI, G</creator><creator>RIZZINI, P</creator><creator>BOTTAZZO, G. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-717346ede12b4a289dec7e553d78f9af41c5f8fdadb5662f14a5953ff762af833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>HLA Antigens</topic><topic>HLA-D Antigens</topic><topic>HLA-DR Antigens</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - immunology</topic><topic>Pancreatitis - pathology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOVO, P</creatorcontrib><creatorcontrib>MIRAKIAN, R</creatorcontrib><creatorcontrib>MERIGO, F</creatorcontrib><creatorcontrib>ANGELINI, G</creatorcontrib><creatorcontrib>CAVALLINI, G</creatorcontrib><creatorcontrib>RIZZINI, P</creatorcontrib><creatorcontrib>BOTTAZZO, G. F</creatorcontrib><creatorcontrib>SCURO, L. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? a preliminary study</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>2</volume><issue>3</issue><spage>350</spage><epage>356</epage><pages>350-356</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis. Pancreatic specimens from 12 chronic pancreatitis patients and nine controls were examined. Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls. Moreover, lymphocytic foci with large numbers of activated cells were found only in chronic pancreatitis. The four HLA-DR - patients had a marked increase of fibrous tissue with small portions of acinar tissue, whereas the six patients with strong positivity had the greatest dilatation and hyperplasia of the ducts. These findings are similar to those observed in immune diseases, such as thyroiditis and primary biliary cirrhosis (PBC), and suggest that autoimmune phenomena are involved in chronic pancreatitis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3498162</pmid><doi>10.1097/00006676-198705000-00016</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pancreas, 1987-01, Vol.2 (3), p.350-356 |
| issn | 0885-3177 1536-4828 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Autoimmune Diseases - immunology Biological and medical sciences Chronic Disease Female Gastroenterology. Liver. Pancreas. Abdomen HLA Antigens HLA-D Antigens HLA-DR Antigens Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocyte Activation Male Medical sciences Middle Aged Other diseases. Semiology Pancreatitis - immunology Pancreatitis - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology |
| title | HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? a preliminary study |
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