Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls
To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 μg), or SRIF (100 μg) on different days. Late auditory evoked potentials (AEP) were computed...
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Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1995, Vol.16 (4), p.657-663 |
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creator | Hartmann, Andreas Dietl, Thomas Krumrey, Klaus Vogl, Luise Dirlich, Gerhard Holsboer, Florian Heuser-Link, Marcus |
description | To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 μg), or SRIF (100 μg) on different days. Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action. |
doi_str_mv | 10.1016/0196-9781(95)00024-E |
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Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. 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Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action.</description><subject>Acoustic Stimulation</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Auditory evoked potentials (AEP)</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Growth hormone-releasing hormone (GHRH)</subject><subject>Growth Hormone-Releasing Hormone - pharmacology</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Placebos</subject><subject>Reaction Time - drug effects</subject><subject>Reference Values</subject><subject>Somatostatin (SRIF)</subject><subject>Somatostatin - pharmacology</subject><subject>Somatotrophic system</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEQgC0EKmnhDUDyCSWHBTter9cXJBSlTaVKSAXOlu2dJIZdO9jeorwST4m3CT3CaaSZb340H0JvKHlPCW0-ECqbSoqWziVfEEKWdbV-hma0FazitJHP0ewJeYkuU_peoLqW7QW6ELWQjJAZ-r3aa7-DhJ3Hvc6A9di5HOIRw0P4AR0-hAw-O91PSDfakjJHvIvhV97jfYhD8FBF6EEn53d_M3h-s7nfLLAZM_Yh4xQGnUPKOpc98y_3t9cLrLcZIj5AdIc9RN1j3Q3Ou5RjoYKfLhp0D9gGn2Po0yv0YlvOgNfneIW-Xa-_rjbV3eeb29Wnu8qyts2V1l0jTMe1oYIK2bBlZ1nXEi0so8QsqeFN-ZXkpCa6FkxaLgG20JrWcMOBXaF3p7mHGH6OkLIaXLLQ99pDGJMSomlJw-R_Qcq5ZJSLAtYn0MaQUoStOkQ36HhUlKjJpZpEqUmUklw9ulTr0vb2PH80A3RPTWd5pf7xVIfyjQcHUSXrwBdFLoLNqgvu3wv-AJoTsRM</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Hartmann, Andreas</creator><creator>Dietl, Thomas</creator><creator>Krumrey, Klaus</creator><creator>Vogl, Luise</creator><creator>Dirlich, Gerhard</creator><creator>Holsboer, Florian</creator><creator>Heuser-Link, Marcus</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls</title><author>Hartmann, Andreas ; 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Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7479300</pmid><doi>10.1016/0196-9781(95)00024-E</doi><tpages>7</tpages></addata></record> |
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subjects | Acoustic Stimulation Adult Analysis of Variance Auditory evoked potentials (AEP) Evoked Potentials, Auditory - drug effects Growth hormone-releasing hormone (GHRH) Growth Hormone-Releasing Hormone - pharmacology Humans Injections, Intravenous Male Placebos Reaction Time - drug effects Reference Values Somatostatin (SRIF) Somatostatin - pharmacology Somatotrophic system |
title | Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls |
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