Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls

To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 μg), or SRIF (100 μg) on different days. Late auditory evoked potentials (AEP) were computed...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1995, Vol.16 (4), p.657-663
Hauptverfasser: Hartmann, Andreas, Dietl, Thomas, Krumrey, Klaus, Vogl, Luise, Dirlich, Gerhard, Holsboer, Florian, Heuser-Link, Marcus
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container_issue 4
container_start_page 657
container_title Peptides (New York, N.Y. : 1980)
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creator Hartmann, Andreas
Dietl, Thomas
Krumrey, Klaus
Vogl, Luise
Dirlich, Gerhard
Holsboer, Florian
Heuser-Link, Marcus
description To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 μg), or SRIF (100 μg) on different days. Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action.
doi_str_mv 10.1016/0196-9781(95)00024-E
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Acoustic Stimulation
Adult
Analysis of Variance
Auditory evoked potentials (AEP)
Evoked Potentials, Auditory - drug effects
Growth hormone-releasing hormone (GHRH)
Growth Hormone-Releasing Hormone - pharmacology
Humans
Injections, Intravenous
Male
Placebos
Reaction Time - drug effects
Reference Values
Somatostatin (SRIF)
Somatostatin - pharmacology
Somatotrophic system
title Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls
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