Poly(I) • poly(C), a potential drug carrier for the antitumor agent mitoxantrone: in vitro drug binding study

Coupling of mitoxantrone, a new antitumor agent, to a macromolecular carrier system may improve the drug's selectivity of action and pharmacokinetic properties. We have studied in vitro binding of mitoxantrone to poly(I).poly(C), a macromolecular, double-stranded homoribopolymer, by equilibrium...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1987-08, Vol.20 (1), p.81-82
Hauptverfasser:	EICHLER, H.-G, MADER, R, BLÖCHL-DAUM, B, STEGER, G, RAINER, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Binding Sites Biological and medical sciences Chromatography, High Pressure Liquid General aspects In Vitro Techniques Medical sciences Mitoxantrone - analysis Mitoxantrone - metabolism Pharmacology. Drug treatments Poly I-C - analysis Poly I-C - metabolism Polylysine - analysis Polylysine - metabolism
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