The role of infiltrating macrophages in islet destruction and regrowth in a transgenic model

The expression of interferon-gamma (IFN-γ) in pancreatic β cells leads to a complex pathology that represents the processes of both islet destruction and islet regeneration. Inflammatory cells and the factors elicited from them participate in the development of pathology in this transgenic model. To...

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Veröffentlicht in:	Journal of autoimmunity 1995-08, Vol.8 (4), p.483-492
Hauptverfasser:	Gu, Danling, O'Reilly, Lorraine, Molony, Leslie, Cooke, Anne, Sarvetnick, Nora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - immunology Cell Movement - immunology Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Islets of Langerhans - immunology Islets of Langerhans - pathology Islets of Langerhans - physiology Macrophages - immunology Macrophages - physiology Male Medical sciences Mice Mice, Inbred BALB C Mice, Transgenic Regeneration - immunology
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