Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity

Cyclic voltammetry data were obtained for 12 salts of quinolines, one pyridine, and one open-chain imine which possess varying degrees of anticancer activity. The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylviny...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1987-06, Vol.76 (6), p.481-484
Hauptverfasser:	Crawford, Philip W., Foye, William O., Ryan, Michael D., Kovacic, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Biological and medical sciences General pharmacology Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pyridines - pharmacology Quinolines - pharmacology Structure-Activity Relationship
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container_end_page	484
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container_title	Journal of pharmaceutical sciences
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creator	Crawford, Philip W. Foye, William O. Ryan, Michael D. Kovacic, Peter
description	Cyclic voltammetry data were obtained for 12 salts of quinolines, one pyridine, and one open-chain imine which possess varying degrees of anticancer activity. The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylvinyl, and guanidine sulfide functionalities. Reduction potentials ranged from −0.43 to −1.08V. The electrochemical results are correlated with structure. A possible mechanism of anticancer action is addressed.
doi_str_mv	10.1002/jps.2600760614
format	Article
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The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylvinyl, and guanidine sulfide functionalities. Reduction potentials ranged from −0.43 to −1.08V. The electrochemical results are correlated with structure. A possible mechanism of anticancer action is addressed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600760614</identifier><identifier>PMID: 3625495</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Antineoplastic Agents - pharmacology ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Physicochemical properties. 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Pharm. Sci</addtitle><description>Cyclic voltammetry data were obtained for 12 salts of quinolines, one pyridine, and one open-chain imine which possess varying degrees of anticancer activity. The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylvinyl, and guanidine sulfide functionalities. Reduction potentials ranged from −0.43 to −1.08V. The electrochemical results are correlated with structure. A possible mechanism of anticancer action is addressed.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. 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Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Pyridines - pharmacology</topic><topic>Quinolines - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crawford, Philip W.</creatorcontrib><creatorcontrib>Foye, William O.</creatorcontrib><creatorcontrib>Ryan, Michael D.</creatorcontrib><creatorcontrib>Kovacic, Peter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crawford, Philip W.</au><au>Foye, William O.</au><au>Ryan, Michael D.</au><au>Kovacic, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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source	Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection
subjects	Antineoplastic Agents - pharmacology Biological and medical sciences General pharmacology Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pyridines - pharmacology Quinolines - pharmacology Structure-Activity Relationship
title	Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity
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