Clonal deletion of major histocompatibility complex class I‐restricted CD4+CD8+ thymocytes in vitro is independent of the CD95 (APO‐1/Fas) ligand

The CD95 (APO‐1/Fas) ligand (CD95L) mediates apoptosis in sensitive target cells, Ca2+‐independent cytotoxicity of cells from perforin knock‐out mice, and peripheral deletion of activated T cells through engagement of its cognate receptor CD95. Double‐positive thymocytes show a high constitutive exp...

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Veröffentlicht in:	European journal of immunology 1995-10, Vol.25 (10), p.2996-2999
Hauptverfasser:	Müller, Klaus‐Peter, Mariani, Sara M., Matiba, Bernd, Kyewski, Bruno, Krammer, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Viral - immunology Apoptosis CD4 Antigens CD8 Antigens CD95 (APO‐1/Fas) ligand Cells, Cultured Clonal Deletion Fas Ligand Protein fas Receptor - physiology H-2 Antigens - immunology Humans L Cells (Cell Line) Leukemia-Lymphoma, Adult T-Cell - pathology lpr Lymphocytic choriomeningitis virus - immunology Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Mice, Transgenic Peptide Fragments - immunology Receptors, Antigen, T-Cell - immunology Receptors, Fc - immunology Self Tolerance T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology Thymocytes Thymus Gland - cytology Tumor Cells, Cultured
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