A possible role of catecholamines in atherogenesis and subsequent complications of atherosclerosis
Cultured smooth muscle cells (SMC) from rat aorta and endothelial cells (EC) from pig aorta were used to study the effect of the catecholamines epinephrine and norepinephrine on cell proliferation. Both stimulated growth of SMC and EC when added to the culture medium. Besides epinephrine and norepin...
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| Veröffentlicht in: | Experimental pathology (1981) 1987, Vol.31 (4), p.193-204 |
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| container_title | Experimental pathology (1981) |
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| creator | Bauch, H.-J. Grünwald, J. Vischer, P. Gerlach, U. Hauss, W.H. |
| description | Cultured smooth muscle cells (SMC) from rat aorta and endothelial cells (EC) from pig aorta were used to study the effect of the catecholamines epinephrine and norepinephrine on cell proliferation. Both stimulated growth of SMC and EC when added to the culture medium. Besides epinephrine and norepinephrine, dopamine and some of their metabolites also stimulated proliferation of cultured endothelial cells. Smooth muscle cells originating from rats being exposed to atherosclerotic risk factors, like diabetes, hypertension and balloon-injury, exhibited an increased susceptibility to these catecholamines compared to SMC from control animals. In comparison to normotensive control animals a 10-fold elevated plasma concentration of epinephrine was found in hypertensive rats.
In man plasma epinephrine and norepinephrine concentration was determined in a healthy control group and in patients suffering from diabetes mellitus and coronary artery disease. Plasma epinephrine and norepinephrine levels were similar in patients suffering from diabetes mellitus compared to the control group. But in patients with coronary artery disease significantly higher plasma concentrations for epinephrine (p < 0.001) and norepinephrine (p < 0.01) were observed. These data support the hypothesis that catecholamines may play a role in the development and subsequent complications of atherosclerosis. |
| doi_str_mv | 10.1016/S0232-1513(87)80001-4 |
| format | Article |
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In man plasma epinephrine and norepinephrine concentration was determined in a healthy control group and in patients suffering from diabetes mellitus and coronary artery disease. Plasma epinephrine and norepinephrine levels were similar in patients suffering from diabetes mellitus compared to the control group. But in patients with coronary artery disease significantly higher plasma concentrations for epinephrine (p < 0.001) and norepinephrine (p < 0.01) were observed. These data support the hypothesis that catecholamines may play a role in the development and subsequent complications of atherosclerosis.</description><identifier>ISSN: 0232-1513</identifier><identifier>DOI: 10.1016/S0232-1513(87)80001-4</identifier><identifier>PMID: 3622722</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; aorta, endothelium ; arteriosclerosis ; Arteriosclerosis - blood ; Arteriosclerosis - complications ; atherogenesis ; atherosclerosis ; catecholamines ; cell culture ; Cell Division - drug effects ; Cells, Cultured ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Diabetes Mellitus, Experimental - blood ; Dopamine - pharmacology ; Dose-Response Relationship, Drug ; epinephrine ; Epinephrine - blood ; Epinephrine - pharmacology ; Humans ; Hypertension - blood ; Male ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - drug effects ; norepinephrine ; Norepinephrine - blood ; Norepinephrine - pharmacology ; plasma ; Rats ; Rats, Inbred Strains ; smooth muscle cells ; Swine</subject><ispartof>Experimental pathology (1981), 1987, Vol.31 (4), p.193-204</ispartof><rights>1987 VEB Gustav Fischer Verlag Jena</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-6caa2aec9d0d33b334efc6af4f8c8cc579510c561e02546aff3c8ec3a4662e8e3</citedby><cites>FETCH-LOGICAL-c360t-6caa2aec9d0d33b334efc6af4f8c8cc579510c561e02546aff3c8ec3a4662e8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3622722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bauch, H.-J.</creatorcontrib><creatorcontrib>Grünwald, J.</creatorcontrib><creatorcontrib>Vischer, P.</creatorcontrib><creatorcontrib>Gerlach, U.</creatorcontrib><creatorcontrib>Hauss, W.H.</creatorcontrib><title>A possible role of catecholamines in atherogenesis and subsequent complications of atherosclerosis</title><title>Experimental pathology (1981)</title><addtitle>Exp Pathol</addtitle><description>Cultured smooth muscle cells (SMC) from rat aorta and endothelial cells (EC) from pig aorta were used to study the effect of the catecholamines epinephrine and norepinephrine on cell proliferation. Both stimulated growth of SMC and EC when added to the culture medium. Besides epinephrine and norepinephrine, dopamine and some of their metabolites also stimulated proliferation of cultured endothelial cells. Smooth muscle cells originating from rats being exposed to atherosclerotic risk factors, like diabetes, hypertension and balloon-injury, exhibited an increased susceptibility to these catecholamines compared to SMC from control animals. In comparison to normotensive control animals a 10-fold elevated plasma concentration of epinephrine was found in hypertensive rats.
In man plasma epinephrine and norepinephrine concentration was determined in a healthy control group and in patients suffering from diabetes mellitus and coronary artery disease. Plasma epinephrine and norepinephrine levels were similar in patients suffering from diabetes mellitus compared to the control group. But in patients with coronary artery disease significantly higher plasma concentrations for epinephrine (p < 0.001) and norepinephrine (p < 0.01) were observed. These data support the hypothesis that catecholamines may play a role in the development and subsequent complications of atherosclerosis.</description><subject>Animals</subject><subject>aorta, endothelium</subject><subject>arteriosclerosis</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - complications</subject><subject>atherogenesis</subject><subject>atherosclerosis</subject><subject>catecholamines</subject><subject>cell culture</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Dopamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>epinephrine</subject><subject>Epinephrine - blood</subject><subject>Epinephrine - pharmacology</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>norepinephrine</subject><subject>Norepinephrine - blood</subject><subject>Norepinephrine - pharmacology</subject><subject>plasma</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>smooth muscle cells</subject><subject>Swine</subject><issn>0232-1513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhnNQVNb9CUJPoodqPtoknkQWv2DBg3oO6XSqkbZZO13Bf29qF69eJmTe981MHsZOBL8QXOjLZy6VzEUp1Jk155ZzLvJijx39tQ_Zkugj9bmW2gp7wA6UltJIecSqm2wTiULVYjbEVGKTgR8R3mPru9AjZaHP_PiOQ3zDdA2U-b7OaFsRfm6xHzOI3aYNKRRiT1N-dhO0Uw10zPYb3xIud-eCvd7dvqwe8vXT_ePqZp2D0nzMNXgvPcJVzWulKqUKbED7pmgsWIDSXJWCQ6kFclkWSWgUWATlC60lWlQLdjq_uxli2oxG1wUCbFvfY9ySM0YbZbhJxnI2QtqPBmzcZgidH76d4G5C6n6Ruomds8b9InVFyp3sBmyrDuu_1A5m0q9nHdMvvwIOjiBgD1iHAWF0dQz_TPgBlKiKPw</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Bauch, H.-J.</creator><creator>Grünwald, J.</creator><creator>Vischer, P.</creator><creator>Gerlach, U.</creator><creator>Hauss, W.H.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>A possible role of catecholamines in atherogenesis and subsequent complications of atherosclerosis</title><author>Bauch, H.-J. ; Grünwald, J. ; Vischer, P. ; Gerlach, U. ; Hauss, W.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-6caa2aec9d0d33b334efc6af4f8c8cc579510c561e02546aff3c8ec3a4662e8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>aorta, endothelium</topic><topic>arteriosclerosis</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - complications</topic><topic>atherogenesis</topic><topic>atherosclerosis</topic><topic>catecholamines</topic><topic>cell culture</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Dopamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>epinephrine</topic><topic>Epinephrine - blood</topic><topic>Epinephrine - pharmacology</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>norepinephrine</topic><topic>Norepinephrine - blood</topic><topic>Norepinephrine - pharmacology</topic><topic>plasma</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>smooth muscle cells</topic><topic>Swine</topic><toplevel>online_resources</toplevel><creatorcontrib>Bauch, H.-J.</creatorcontrib><creatorcontrib>Grünwald, J.</creatorcontrib><creatorcontrib>Vischer, P.</creatorcontrib><creatorcontrib>Gerlach, U.</creatorcontrib><creatorcontrib>Hauss, W.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental pathology (1981)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bauch, H.-J.</au><au>Grünwald, J.</au><au>Vischer, P.</au><au>Gerlach, U.</au><au>Hauss, W.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A possible role of catecholamines in atherogenesis and subsequent complications of atherosclerosis</atitle><jtitle>Experimental pathology (1981)</jtitle><addtitle>Exp Pathol</addtitle><date>1987</date><risdate>1987</risdate><volume>31</volume><issue>4</issue><spage>193</spage><epage>204</epage><pages>193-204</pages><issn>0232-1513</issn><abstract>Cultured smooth muscle cells (SMC) from rat aorta and endothelial cells (EC) from pig aorta were used to study the effect of the catecholamines epinephrine and norepinephrine on cell proliferation. Both stimulated growth of SMC and EC when added to the culture medium. Besides epinephrine and norepinephrine, dopamine and some of their metabolites also stimulated proliferation of cultured endothelial cells. Smooth muscle cells originating from rats being exposed to atherosclerotic risk factors, like diabetes, hypertension and balloon-injury, exhibited an increased susceptibility to these catecholamines compared to SMC from control animals. In comparison to normotensive control animals a 10-fold elevated plasma concentration of epinephrine was found in hypertensive rats.
In man plasma epinephrine and norepinephrine concentration was determined in a healthy control group and in patients suffering from diabetes mellitus and coronary artery disease. Plasma epinephrine and norepinephrine levels were similar in patients suffering from diabetes mellitus compared to the control group. But in patients with coronary artery disease significantly higher plasma concentrations for epinephrine (p < 0.001) and norepinephrine (p < 0.01) were observed. These data support the hypothesis that catecholamines may play a role in the development and subsequent complications of atherosclerosis.</abstract><cop>Germany</cop><pmid>3622722</pmid><doi>10.1016/S0232-1513(87)80001-4</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals aorta, endothelium arteriosclerosis Arteriosclerosis - blood Arteriosclerosis - complications atherogenesis atherosclerosis catecholamines cell culture Cell Division - drug effects Cells, Cultured Coronary Artery Disease - blood Coronary Artery Disease - complications Diabetes Mellitus, Experimental - blood Dopamine - pharmacology Dose-Response Relationship, Drug epinephrine Epinephrine - blood Epinephrine - pharmacology Humans Hypertension - blood Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects norepinephrine Norepinephrine - blood Norepinephrine - pharmacology plasma Rats Rats, Inbred Strains smooth muscle cells Swine |
| title | A possible role of catecholamines in atherogenesis and subsequent complications of atherosclerosis |
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