Biological properties of chimeric domain-deleted anticarcinoma immunoglobulins

CC49 is a second-generation monoclonal antibody (MAb) that has high affinity for the tumor-associated pancarcinoma antigen tumor-associated glycoprotein-72. In clinical trials using gamma scanning, radiolabeled CC49 has facilitated the detection of more than 90% of carcinomas. We report here the dev...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-12, Vol.55 (23 Suppl), p.5957s-5967s
Hauptverfasser:	Slavin-Chiorini, D C, Kashmiri, S V, Schlom, J, Calvo, B, Shu, L M, Schott, M E, Milenic, D E, Snoy, P, Carrasquillo, J, Anderson, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - genetics Antibodies, Neoplasm - immunology Antibodies, Neoplasm - metabolism Carcinoma - diagnostic imaging Colonic Neoplasms - diagnostic imaging DNA, Complementary - genetics DNA, Complementary - isolation & purification Escherichia coli - genetics Gene Deletion Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Iodine Radioisotopes Macaca mulatta Mice Mice, Nude Radioimmunodetection Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - pharmacokinetics Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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