Circulating Erythroid Progenitors in the Anemia of Prematurity

We studied erythropoiesis in infants with the anemia of prematurity by counting the number of colonies derived from erythroid burst-forming units (BFU-E) in the blood of 11 premature infants before they received transfusions. Colony growth in blood from the infants was compared with growth in blood...

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Veröffentlicht in:	The New England journal of medicine 1987-09, Vol.317 (12), p.728-733
Hauptverfasser:	Shannon, Kevin M, Naylor, Gordon S, Torkildson, Joseph C, Clemons, Gisela K, Schaffner, Vann, Goldman, Steven L, Lewis, Kathleen, Bryant, Paulette, Phibbs, Roderic
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Anemia Anemia - blood Anemia - physiopathology Anemia - therapy Anemias. Hemoglobinopathies Biological and medical sciences Blood Transfusion Diseases of red blood cells Erythrocyte Count Erythropoiesis Erythropoietin - analysis Erythropoietin - therapeutic use Globins - biosynthesis Hematologic and hematopoietic diseases Hematopoietic Stem Cells - cytology Humans Infant, Newborn Infant, Premature, Diseases - blood Infant, Premature, Diseases - physiopathology Infant, Premature, Diseases - therapy Medical sciences
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Zusammenfassung:	We studied erythropoiesis in infants with the anemia of prematurity by counting the number of colonies derived from erythroid burst-forming units (BFU-E) in the blood of 11 premature infants before they received transfusions. Colony growth in blood from the infants was compared with growth in blood from adults and umbilical-cord blood from term infants, in the presence of erythropoietin, 0 to 2000 mU per milliliter. Addition of increasing concentrations of erythropoietin resulted in a stepwise increase in the number of colonies derived from BFU-E (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198709173171203