Identification of Two Glucuronide Metabolites of Doxylamine via Thermospray/Mass Spectrometry and Thermospray/Mass Spectrometry/Mass Spectrometry

Analysis of a high-pressure liquid chromatography fraction containing two urinary glucuronlde metabolites of doxylamine by thermospray mass spectrometry (TSP/MS) provided [MH]+ ions for each metabollte. TSP/MS/MS of the [MH]+ ions provided a fragment Ion characteristic of these metsbolltes. The resu...

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Veröffentlicht in:	Journal of analytical toxicology 1987-07, Vol.11 (4), p.182-184
Hauptverfasser:	Korfmacher, W.A., Holder, C.L., Betowski, L.D., Mitchum, R.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid Doxylamine - metabolism General pharmacology Glucuronates - analysis Male Mass Spectrometry Medical sciences Methods Pharmacology. Drug treatments Pyridines - metabolism Rats Rats, Inbred F344
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Zusammenfassung:	Analysis of a high-pressure liquid chromatography fraction containing two urinary glucuronlde metabolites of doxylamine by thermospray mass spectrometry (TSP/MS) provided [MH]+ ions for each metabollte. TSP/MS/MS of the [MH]+ ions provided a fragment Ion characteristic of these metsbolltes. The results demonstrate the utility of TSP/MS analysis for biologically derived glucuronlde metabolites.
ISSN:	0146-4760 1945-2403
DOI:	10.1093/jat/11.4.182