Freeze Fracture Analysis of Muscle Plasma Membrane in Bupivacaine HCl-induced Degeneration and Regeneration
We did freeze fracture analysis of bupivacaine HCl-induced muscle fiber damage. The muscle plasma membrane in rat extensor digitorum longus and soleus muscle was analyzed for the density of orthogonal arrays and caveolae at periods of five minutes to 60 days after application of the myotoxin. In deg...
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| Veröffentlicht in: | Journal of neuropathology and experimental neurology 1987-09, Vol.46 (5), p.522-532 |
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| container_title | Journal of neuropathology and experimental neurology |
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| creator | YOSHIMURA, TOSHIRO SCHOTLAND, DONALD L |
| description | We did freeze fracture analysis of bupivacaine HCl-induced muscle fiber damage. The muscle plasma membrane in rat extensor digitorum longus and soleus muscle was analyzed for the density of orthogonal arrays and caveolae at periods of five minutes to 60 days after application of the myotoxin. In degenerating muscle a decrease in the density of caveolae was observed. In regenerating extensor digitorum longus muscle, a decrease in the density of orthogonal arrays and an increase in the density of caveolae was present. The results shows that freeze fracture alterations in fast twitch regenerating muscle are similar to those seen in the muscles of patients with Duchenne muscular dystrophy. |
| doi_str_mv | 10.1097/00005072-198709000-00002 |
| format | Article |
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The muscle plasma membrane in rat extensor digitorum longus and soleus muscle was analyzed for the density of orthogonal arrays and caveolae at periods of five minutes to 60 days after application of the myotoxin. In degenerating muscle a decrease in the density of caveolae was observed. In regenerating extensor digitorum longus muscle, a decrease in the density of orthogonal arrays and an increase in the density of caveolae was present. The results shows that freeze fracture alterations in fast twitch regenerating muscle are similar to those seen in the muscles of patients with Duchenne muscular dystrophy.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1097/00005072-198709000-00002</identifier><identifier>PMID: 3625233</identifier><identifier>CODEN: JNENAD</identifier><language>eng</language><publisher>Hagerstown, MD: American Association of Neuropathologists, Inc</publisher><subject>Animals ; Biological and medical sciences ; Bupivacaine ; Cell Membrane - ultrastructure ; Cell Survival ; degeneration ; Freeze Fracturing ; Male ; Medical sciences ; Muscles - drug effects ; Muscles - physiology ; Muscles - ultrastructure ; Muscular Dystrophy, Animal - pathology ; Muscular Dystrophy, Animal - physiopathology ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Rats ; Rats, Inbred Strains ; regeneration ; Regeneration - drug effects ; skeletal muscle</subject><ispartof>Journal of neuropathology and experimental neurology, 1987-09, Vol.46 (5), p.522-532</ispartof><rights>1987 American Association of Neuropathologists, Inc</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4152-7b100a1a9068bbe6b3564568fed09fd6f92b3ba165adff5076e90fcc7fc602ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7696236$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3625233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIMURA, TOSHIRO</creatorcontrib><creatorcontrib>SCHOTLAND, DONALD L</creatorcontrib><title>Freeze Fracture Analysis of Muscle Plasma Membrane in Bupivacaine HCl-induced Degeneration and Regeneration</title><title>Journal of neuropathology and experimental neurology</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>We did freeze fracture analysis of bupivacaine HCl-induced muscle fiber damage. The muscle plasma membrane in rat extensor digitorum longus and soleus muscle was analyzed for the density of orthogonal arrays and caveolae at periods of five minutes to 60 days after application of the myotoxin. In degenerating muscle a decrease in the density of caveolae was observed. In regenerating extensor digitorum longus muscle, a decrease in the density of orthogonal arrays and an increase in the density of caveolae was present. The results shows that freeze fracture alterations in fast twitch regenerating muscle are similar to those seen in the muscles of patients with Duchenne muscular dystrophy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cell Survival</subject><subject>degeneration</subject><subject>Freeze Fracturing</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - drug effects</subject><subject>Muscles - physiology</subject><subject>Muscles - ultrastructure</subject><subject>Muscular Dystrophy, Animal - pathology</subject><subject>Muscular Dystrophy, Animal - physiopathology</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>regeneration</subject><subject>Regeneration - drug effects</subject><subject>skeletal muscle</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EKkvhJyD5gLgF_BHb8bFsWYrUqhWCczRxxtTUSRY7oWp_PS67rHpB-DKad56xR_OaEMrZO86sec_KUcyIitvGMFuy6kEST8iKK1VXWpnmKVkVRVSSafucvMj5RyEss_UROZJaKCHlitxsEuI90k0CNy8J6ckI8S6HTCdPL5bsItKrCHkAeoFDl2BEGkb6YdmGX-AglPRsHasw9ovDnp7idxwxwRymkcLY0y-PhJfkmYeY8dU-HpNvm49f12fV-eWnz-uT88rVXInKdJwx4GCZbroOdSeVrpVuPPbM-l57KzrZAdcKeu_LFjRa5p0z3mkm0Mlj8nZ37zZNPxfMczuE7DDGMvy05NYYbTir5X9BXptGqIYVsNmBLk05J_TtNoUB0l3LWftgSPvXkPZgyB9JlNbX-zeWbsD-0Lh3oNTf7OuQHURfNuxCPmBGWy2kLli9w26nOGPKN3G5xdReI8T5uv3Xd5C_AVtsoss</recordid><startdate>198709</startdate><enddate>198709</enddate><creator>YOSHIMURA, TOSHIRO</creator><creator>SCHOTLAND, DONALD L</creator><general>American Association of Neuropathologists, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198709</creationdate><title>Freeze Fracture Analysis of Muscle Plasma Membrane in Bupivacaine HCl-induced Degeneration and Regeneration</title><author>YOSHIMURA, TOSHIRO ; SCHOTLAND, DONALD L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-7b100a1a9068bbe6b3564568fed09fd6f92b3ba165adff5076e90fcc7fc602ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine</topic><topic>Cell Membrane - ultrastructure</topic><topic>Cell Survival</topic><topic>degeneration</topic><topic>Freeze Fracturing</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - drug effects</topic><topic>Muscles - physiology</topic><topic>Muscles - ultrastructure</topic><topic>Muscular Dystrophy, Animal - pathology</topic><topic>Muscular Dystrophy, Animal - physiopathology</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>regeneration</topic><topic>Regeneration - drug effects</topic><topic>skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOSHIMURA, TOSHIRO</creatorcontrib><creatorcontrib>SCHOTLAND, DONALD L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuropathology and experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIMURA, TOSHIRO</au><au>SCHOTLAND, DONALD L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Freeze Fracture Analysis of Muscle Plasma Membrane in Bupivacaine HCl-induced Degeneration and Regeneration</atitle><jtitle>Journal of neuropathology and experimental neurology</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>1987-09</date><risdate>1987</risdate><volume>46</volume><issue>5</issue><spage>522</spage><epage>532</epage><pages>522-532</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><coden>JNENAD</coden><abstract>We did freeze fracture analysis of bupivacaine HCl-induced muscle fiber damage. The muscle plasma membrane in rat extensor digitorum longus and soleus muscle was analyzed for the density of orthogonal arrays and caveolae at periods of five minutes to 60 days after application of the myotoxin. In degenerating muscle a decrease in the density of caveolae was observed. In regenerating extensor digitorum longus muscle, a decrease in the density of orthogonal arrays and an increase in the density of caveolae was present. The results shows that freeze fracture alterations in fast twitch regenerating muscle are similar to those seen in the muscles of patients with Duchenne muscular dystrophy.</abstract><cop>Hagerstown, MD</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>3625233</pmid><doi>10.1097/00005072-198709000-00002</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0022-3069 |
| ispartof | Journal of neuropathology and experimental neurology, 1987-09, Vol.46 (5), p.522-532 |
| issn | 0022-3069 1554-6578 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Bupivacaine Cell Membrane - ultrastructure Cell Survival degeneration Freeze Fracturing Male Medical sciences Muscles - drug effects Muscles - physiology Muscles - ultrastructure Muscular Dystrophy, Animal - pathology Muscular Dystrophy, Animal - physiopathology Nervous system involvement in other diseases. Miscellaneous Neurology Rats Rats, Inbred Strains regeneration Regeneration - drug effects skeletal muscle |
| title | Freeze Fracture Analysis of Muscle Plasma Membrane in Bupivacaine HCl-induced Degeneration and Regeneration |
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