Stability measurements of antisense oligonucleotides by capillary gel electrophoresis

The approach of using antisense oligonucleotides as potential drugs is based on hybridization of a short chemically-modified oligonucleotide with complementary cellular DNA or RNA sequences. A critical question is the stability of chemically modified antisense oligonucleotides in cellular environmen...

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Veröffentlicht in:	Journal of Chromatography A 1995-08, Vol.709 (1), p.181-195
Hauptverfasser:	Bruin, Gerard J.M., Olaf Börnsen, K., Hüsken, Dieter, Gassmann, Ernst, Michael Widmer, H., Paulus, Aran
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Electrophoresis - methods Endonucleases - chemistry Mass Spectrometry - methods Molecular Sequence Data Oligonucleotides, Antisense - chemistry Poly T - chemistry Snake Venoms - enzymology
Online-Zugang:	Volltext
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