Regional metabolism of Met-enkephalin and cholecystokinin on intact ratbrain slices: characterization of specific peptidases

The metabolism of Met-enkephalin and cholecystokinin (CCK) 8-(sulfated) by intact microslices was studied in rat brain regions. Incubation of brain slices with Met-enkephalin (400 microM) resulted in a linear rate of disappearance of parent peptide and appearance of metabolic fragments whose rate of...

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Veröffentlicht in:	Journal of neurochemistry 1995-12, Vol.65 (6), p.2773-2782
Hauptverfasser:	Konkoy, C S, Davis, T P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidases - antagonists & inhibitors Aminopeptidases - metabolism Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Brain - metabolism Cholecystokinin - metabolism Endopeptidases - metabolism Enkephalin, Methionine - metabolism In Vitro Techniques Male Neprilysin - antagonists & inhibitors Neprilysin - metabolism Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley Tissue Distribution
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