Prevention of tolerance to nitroglycerin patches by overnight removal
This investigation assesses the extent of tolerance development with nitroglycerin patches and whether tolerance might be prevented by overnight patch removal. On commencing therapy, active patches significantly prolonged exercise time (3.5 hours after patch application) in comparison with placebo,...
Gespeichert in:
| Veröffentlicht in: | The American journal of cardiology 1987-08, Vol.60 (4), p.271-275 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 275 |
|---|---|
| container_issue | 4 |
| container_start_page | 271 |
| container_title | The American journal of cardiology |
| container_volume | 60 |
| creator | Cowan, J.Campbell Bourke, John P. Reid, Douglas S. Julian, Desmond G. |
| description | This investigation assesses the extent of tolerance development with nitroglycerin patches and whether tolerance might be prevented by overnight patch removal. On commencing therapy, active patches significantly prolonged exercise time (3.5 hours after patch application) in comparison with placebo, with an accompanying reduction in ST-segment depression at maximal common workload. Patients then received continuous or 12-hour-daily intermittent patch therapy, in a double-blind fashion, for 7 days. Exercise testing was repeated before and after active patch application, on the eighth day of each treatment phase. During continuous therapy, beneficial effects on exercise time and ST depression were abolished. By contrast, during intermittent therapy, prolongation of exercise time and reduction in ST-segment depression still occurred, on testing 3.5 hours after active patch application. These results confirm previous studies showing a high degree of tolerance during continuous therapy with nitroglycerin patches and suggest that tolerance can be prevented by 12-hour-daily intermittent therapy. |
| doi_str_mv | 10.1016/0002-9149(87)90226-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77667439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002914987902268</els_id><sourcerecordid>77667439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-49b3f67e013fc4a7ad0862a71364bdc73e74fb2d19d6af4354d5b4327d590933</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoWqtvoDALEV2M5jbJZCNI8QYFXXQfMskZjUwnNZkW-vamtnTpKgn_dy75ELog-I5gIu4xxrRUhKubWt4qTKko6wM0IrVUJVGEHaLRHjlBpyl95ychlThGx4wQRikboaePCCvoBx_6IrTFEDqIpreQb0Xvhxg-u7WF6PtiYQb7Balo1kVYQez959dQRJiHlenO0FFrugTnu3OMZs9Ps8lrOX1_eZs8TkvLKzqUXDWsFRIwYa3lRhqHa0GNJEzwxlnJQPK2oY4oJ0zLWcVd1XBGpasUVoyN0fW27SKGnyWkQc99stB1poewTFpKISRnKoN8C9oYUorQ6kX0cxPXmmC9kac3ZvTGjK6l_pOn61x2ueu_bObg9kU7Wzm_2uUmWdO1G1M-7bE8Wsj8mTF62GKQVaw8RJ2shyzV-Qh20C74__f4BSrLiqc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77667439</pqid></control><display><type>article</type><title>Prevention of tolerance to nitroglycerin patches by overnight removal</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cowan, J.Campbell ; Bourke, John P. ; Reid, Douglas S. ; Julian, Desmond G.</creator><creatorcontrib>Cowan, J.Campbell ; Bourke, John P. ; Reid, Douglas S. ; Julian, Desmond G.</creatorcontrib><description>This investigation assesses the extent of tolerance development with nitroglycerin patches and whether tolerance might be prevented by overnight patch removal. On commencing therapy, active patches significantly prolonged exercise time (3.5 hours after patch application) in comparison with placebo, with an accompanying reduction in ST-segment depression at maximal common workload. Patients then received continuous or 12-hour-daily intermittent patch therapy, in a double-blind fashion, for 7 days. Exercise testing was repeated before and after active patch application, on the eighth day of each treatment phase. During continuous therapy, beneficial effects on exercise time and ST depression were abolished. By contrast, during intermittent therapy, prolongation of exercise time and reduction in ST-segment depression still occurred, on testing 3.5 hours after active patch application. These results confirm previous studies showing a high degree of tolerance during continuous therapy with nitroglycerin patches and suggest that tolerance can be prevented by 12-hour-daily intermittent therapy.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(87)90226-8</identifier><identifier>PMID: 3113223</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Cutaneous ; Adult ; Angina Pectoris - prevention & control ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Clinical Trials as Topic ; Double-Blind Method ; Drug Administration Schedule ; Drug Tolerance ; Exercise Test ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nitroglycerin - administration & dosage ; Nitroglycerin - therapeutic use ; Pharmacology. Drug treatments ; Random Allocation ; Time Factors</subject><ispartof>The American journal of cardiology, 1987-08, Vol.60 (4), p.271-275</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-49b3f67e013fc4a7ad0862a71364bdc73e74fb2d19d6af4354d5b4327d590933</citedby><cites>FETCH-LOGICAL-c452t-49b3f67e013fc4a7ad0862a71364bdc73e74fb2d19d6af4354d5b4327d590933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9149(87)90226-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7436771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3113223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cowan, J.Campbell</creatorcontrib><creatorcontrib>Bourke, John P.</creatorcontrib><creatorcontrib>Reid, Douglas S.</creatorcontrib><creatorcontrib>Julian, Desmond G.</creatorcontrib><title>Prevention of tolerance to nitroglycerin patches by overnight removal</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>This investigation assesses the extent of tolerance development with nitroglycerin patches and whether tolerance might be prevented by overnight patch removal. On commencing therapy, active patches significantly prolonged exercise time (3.5 hours after patch application) in comparison with placebo, with an accompanying reduction in ST-segment depression at maximal common workload. Patients then received continuous or 12-hour-daily intermittent patch therapy, in a double-blind fashion, for 7 days. Exercise testing was repeated before and after active patch application, on the eighth day of each treatment phase. During continuous therapy, beneficial effects on exercise time and ST depression were abolished. By contrast, during intermittent therapy, prolongation of exercise time and reduction in ST-segment depression still occurred, on testing 3.5 hours after active patch application. These results confirm previous studies showing a high degree of tolerance during continuous therapy with nitroglycerin patches and suggest that tolerance can be prevented by 12-hour-daily intermittent therapy.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Angina Pectoris - prevention & control</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Drug Tolerance</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Time Factors</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMoWqtvoDALEV2M5jbJZCNI8QYFXXQfMskZjUwnNZkW-vamtnTpKgn_dy75ELog-I5gIu4xxrRUhKubWt4qTKko6wM0IrVUJVGEHaLRHjlBpyl95ychlThGx4wQRikboaePCCvoBx_6IrTFEDqIpreQb0Xvhxg-u7WF6PtiYQb7Balo1kVYQez959dQRJiHlenO0FFrugTnu3OMZs9Ps8lrOX1_eZs8TkvLKzqUXDWsFRIwYa3lRhqHa0GNJEzwxlnJQPK2oY4oJ0zLWcVd1XBGpasUVoyN0fW27SKGnyWkQc99stB1poewTFpKISRnKoN8C9oYUorQ6kX0cxPXmmC9kac3ZvTGjK6l_pOn61x2ueu_bObg9kU7Wzm_2uUmWdO1G1M-7bE8Wsj8mTF62GKQVaw8RJ2shyzV-Qh20C74__f4BSrLiqc</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Cowan, J.Campbell</creator><creator>Bourke, John P.</creator><creator>Reid, Douglas S.</creator><creator>Julian, Desmond G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870801</creationdate><title>Prevention of tolerance to nitroglycerin patches by overnight removal</title><author>Cowan, J.Campbell ; Bourke, John P. ; Reid, Douglas S. ; Julian, Desmond G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-49b3f67e013fc4a7ad0862a71364bdc73e74fb2d19d6af4354d5b4327d590933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Angina Pectoris - prevention & control</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Drug Tolerance</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cowan, J.Campbell</creatorcontrib><creatorcontrib>Bourke, John P.</creatorcontrib><creatorcontrib>Reid, Douglas S.</creatorcontrib><creatorcontrib>Julian, Desmond G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cowan, J.Campbell</au><au>Bourke, John P.</au><au>Reid, Douglas S.</au><au>Julian, Desmond G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of tolerance to nitroglycerin patches by overnight removal</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>60</volume><issue>4</issue><spage>271</spage><epage>275</epage><pages>271-275</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>This investigation assesses the extent of tolerance development with nitroglycerin patches and whether tolerance might be prevented by overnight patch removal. On commencing therapy, active patches significantly prolonged exercise time (3.5 hours after patch application) in comparison with placebo, with an accompanying reduction in ST-segment depression at maximal common workload. Patients then received continuous or 12-hour-daily intermittent patch therapy, in a double-blind fashion, for 7 days. Exercise testing was repeated before and after active patch application, on the eighth day of each treatment phase. During continuous therapy, beneficial effects on exercise time and ST depression were abolished. By contrast, during intermittent therapy, prolongation of exercise time and reduction in ST-segment depression still occurred, on testing 3.5 hours after active patch application. These results confirm previous studies showing a high degree of tolerance during continuous therapy with nitroglycerin patches and suggest that tolerance can be prevented by 12-hour-daily intermittent therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3113223</pmid><doi>10.1016/0002-9149(87)90226-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 1987-08, Vol.60 (4), p.271-275 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77667439 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Cutaneous Adult Angina Pectoris - prevention & control Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Drug Tolerance Exercise Test Female Humans Male Medical sciences Middle Aged Nitroglycerin - administration & dosage Nitroglycerin - therapeutic use Pharmacology. Drug treatments Random Allocation Time Factors |
| title | Prevention of tolerance to nitroglycerin patches by overnight removal |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A09%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevention%20of%20tolerance%20to%20nitroglycerin%20patches%20by%20overnight%20removal&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Cowan,%20J.Campbell&rft.date=1987-08-01&rft.volume=60&rft.issue=4&rft.spage=271&rft.epage=275&rft.pages=271-275&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/0002-9149(87)90226-8&rft_dat=%3Cproquest_cross%3E77667439%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77667439&rft_id=info:pmid/3113223&rft_els_id=0002914987902268&rfr_iscdi=true |