Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids
The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increas...
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| Veröffentlicht in: | Journal of neuroimmunology 1987-10, Vol.16 (2), p.253-259 |
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| container_title | Journal of neuroimmunology |
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| creator | Paciotti, Giulio F. Skwerer, Robert G. Tamarkin, Lawrence |
| description | The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone levels. However, chronic in vivo exposure to dexamethasone resulted in lymphocyte activity which was equivalent to controls, while chronic isoproterenol treatment enhanced the lymphocyte response to mitogen. These data suggest that chronic stress may result in a desensitization of the immune system to corticosteroids as well as a direct in vivo modulation by isoproterenol to enhance lymphocyte proliferation. |
| doi_str_mv | 10.1016/0165-5728(87)90079-8 |
| format | Article |
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Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone levels. However, chronic in vivo exposure to dexamethasone resulted in lymphocyte activity which was equivalent to controls, while chronic isoproterenol treatment enhanced the lymphocyte response to mitogen. These data suggest that chronic stress may result in a desensitization of the immune system to corticosteroids as well as a direct in vivo modulation by isoproterenol to enhance lymphocyte proliferation.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(87)90079-8</identifier><identifier>PMID: 3305570</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adrenalectomy ; Animals ; Biological and medical sciences ; Cells, Cultured ; Corticosteroid ; Desensitization ; Dexamethasone - pharmacology ; Immunity, Cellular - drug effects ; Immunomodulators ; Insulin - pharmacology ; Isoproterenol ; Isoproterenol - pharmacology ; Lymphocyte ; Lymphocyte Activation - drug effects ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Spleen - immunology</subject><ispartof>Journal of neuroimmunology, 1987-10, Vol.16 (2), p.253-259</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7f3f42abf31593ac7ff06593de5f5b11e25df2946967eb6a23dd70e33d989d733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0165572887900798$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7660065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3305570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paciotti, Giulio F.</creatorcontrib><creatorcontrib>Skwerer, Robert G.</creatorcontrib><creatorcontrib>Tamarkin, Lawrence</creatorcontrib><title>Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone levels. However, chronic in vivo exposure to dexamethasone resulted in lymphocyte activity which was equivalent to controls, while chronic isoproterenol treatment enhanced the lymphocyte response to mitogen. These data suggest that chronic stress may result in a desensitization of the immune system to corticosteroids as well as a direct in vivo modulation by isoproterenol to enhance lymphocyte proliferation.</description><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Corticosteroid</subject><subject>Desensitization</subject><subject>Dexamethasone - pharmacology</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunomodulators</subject><subject>Insulin - pharmacology</subject><subject>Isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>Lymphocyte</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spleen - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhStGM_aMvoEmLIzRRSkURVHlwsTM-JdM4kbXhIbLNIaCkkuZtK_lC0rbnV7qggDhu_cc7mmaJ4y-YpQNr-sSrZDd-GKULydK5dSO95oNG2XXjn3H7jebM_KwuUT8TikTvJ8umgvOqRCSbprfN945yBCL14FkwCVFBJIcyboQXAJEb0jYz8sumX0BJCUR3KVc2gJ5JjpaElK8O94irDlBtMlkH4GYnQ61wR3gG7IkRL8NQCwgRPTF_9LFp3iQKrvKQghr0Jn4eV5r7dlK1TNVzpuEVSN5i4-aB04HhMen_ar59uH91-tP7e2Xj5-v3922pmeytNJx13d66zgTE9dGOkeHerIgnNgyBp2wrpv6YRokbAfdcWslBc7tNE5Wcn7VPD_2XXL6sQIWNXs8-NQR0opKymHoO9H9F2T9yOu4RQX7I2hyHUcGp5bsZ533ilF1CFUdElOHxNQo1d9Q1VjLnp76r9sZ7LnolGJ9f3Z612h0cFlH4_GMVZu0_rxib48Y1KH99JAVGg_RgPUZTFE2-X_7-APfI8N4</recordid><startdate>19871001</startdate><enddate>19871001</enddate><creator>Paciotti, Giulio F.</creator><creator>Skwerer, Robert G.</creator><creator>Tamarkin, Lawrence</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19871001</creationdate><title>Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids</title><author>Paciotti, Giulio F. ; Skwerer, Robert G. ; Tamarkin, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7f3f42abf31593ac7ff06593de5f5b11e25df2946967eb6a23dd70e33d989d733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Corticosteroid</topic><topic>Desensitization</topic><topic>Dexamethasone - pharmacology</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunomodulators</topic><topic>Insulin - pharmacology</topic><topic>Isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>Lymphocyte</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spleen - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paciotti, Giulio F.</creatorcontrib><creatorcontrib>Skwerer, Robert G.</creatorcontrib><creatorcontrib>Tamarkin, Lawrence</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paciotti, Giulio F.</au><au>Skwerer, Robert G.</au><au>Tamarkin, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1987-10-01</date><risdate>1987</risdate><volume>16</volume><issue>2</issue><spage>253</spage><epage>259</epage><pages>253-259</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone levels. However, chronic in vivo exposure to dexamethasone resulted in lymphocyte activity which was equivalent to controls, while chronic isoproterenol treatment enhanced the lymphocyte response to mitogen. These data suggest that chronic stress may result in a desensitization of the immune system to corticosteroids as well as a direct in vivo modulation by isoproterenol to enhance lymphocyte proliferation.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3305570</pmid><doi>10.1016/0165-5728(87)90079-8</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1987-10, Vol.16 (2), p.253-259 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenalectomy Animals Biological and medical sciences Cells, Cultured Corticosteroid Desensitization Dexamethasone - pharmacology Immunity, Cellular - drug effects Immunomodulators Insulin - pharmacology Isoproterenol Isoproterenol - pharmacology Lymphocyte Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Spleen - immunology |
| title | Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids |
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