Endothelial cells in culture produce a vasoconstrictor substance

We report that cultured vascular endothelial cells release into the culture medium a vasoconstrictor peptide, a substance we call an endotheliumderived constricting factor (EDCF). Conditioned medium from cultured bovine aortic and pulmonary artery endothelial cells caused sustained, dose‐dependent i...

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Veröffentlicht in:	Journal of cellular physiology 1987-08, Vol.132 (2), p.263-270
Hauptverfasser:	O'Brien, Richard F., Robbins, Richard J., McMurtry, Ivan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta, Thoracic - metabolism Biological and medical sciences Calcimycin - pharmacology Cattle Cell physiology Cells, Cultured Culture Media endothelial-derived constricting factor Endothelins Endothelium - metabolism Fundamental and applied biological sciences. Psychology Molecular and cellular biology Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Peptide Biosynthesis Pulmonary Artery - metabolism Rabbits Rats Secretion. Exocytosis Thrombin - pharmacology Vasoconstriction - drug effects Vasoconstrictor Agents - metabolism Vasoconstrictor Agents - pharmacology vasoconstrictors Vasodilator Agents - pharmacology
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