Metabolism of [5‐3H]Kynurenine in the Rat Brain In Vivo: Evidence for the Existence of a Functional Kynurenine Pathway

: The incorporation of tritium label into quinolinic acid (QUIN), kynurenic acid (KYNA), and other kynurenine (KYN) pathway metabolites was studied in normal and QUIN‐lesioned rat striata after a focal injection of [5‐3H]KYN in vivo. The time course of metabolite accumulation was examined 15 min to...

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Veröffentlicht in:	Journal of neurochemistry 1995-12, Vol.65 (6), p.2621-2632
Hauptverfasser:	Guidetti, Paolo, Eastman, Clifford L., Schwarcz, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Central nervous system Excitotoxicity Fundamental and applied biological sciences. Psychology Hydrolases - metabolism Kynurenic acid Kynurenine - metabolism Kynurenine 3-Monooxygenase Kynurenines Male Mixed Function Oxygenases - metabolism Neuroprotection Osmolar Concentration Quinolinic acid Quinolinic Acid - pharmacology Rats Rats, Sprague-Dawley Time Factors Tritium Vertebrates: nervous system and sense organs
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