Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C-Independent Mechanism

Many obese hypertensive individuals have a cluster of cardiovascular risk factors. This cluster includes plasma nonesterified fatty acid concentrations and turnover rates that are higher and more resistant to suppression by insulin than in lean and obese normotensive individuals. The higher fatty ac...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1995-11, Vol.26 (5), p.764-770
Hauptverfasser:	Davda, Rajesh K, Stepniakowski, Konrad T, Lu, Gang, Ullian, Michael E, Goodfriend, Theodore L, Egan, Brent M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cattle Cells, Cultured Endothelium, Vascular - metabolism Enzyme Activation - drug effects Experimental diseases Femoral Artery - drug effects Femoral Artery - physiology Humans Hypertension - metabolism Medical sciences Nitric Oxide Synthase - antagonists & inhibitors Oleic Acid Oleic Acids - blood Oleic Acids - pharmacology Protein Kinase C - metabolism Rabbits Vasodilation - drug effects
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