Interferon-γ: pleiotropic effects on a rat pancreatic beta cell line

We have recently shown that interferon-y (IFN-y) markedly upregulates the expression of the class I major histocompatibility proteins on pancreatic beta cells and have therefore postulated that interferon-y may enhance cytotoxic lymphocyte-mediated beta cell damage in insulin-dependent diabetes mell...

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Veröffentlicht in:	Molecular and cellular endocrinology 1987-07, Vol.52 (1), p.161-167
Hauptverfasser:	Campbell, Iain L., Oxbrow, Leonie, Harrison, Leonard C.
Format:	Artikel
Sprache:	eng
Schlagworte:	(Pro)insulin Adenoma, Islet Cell - immunology Animals Biological and medical sciences Cell growth Cell Line Gynecology. Andrology. Obstetrics Histocompatibility Antigens - analysis Histocompatibility Antigens - genetics Insulinoma - immunology Interferon-gamma - pharmacology Interferon-γ Kinetics Major Histocompatibility Complex - drug effects Mammary gland diseases Medical sciences MHC expression Non tumoral diseases Pancreatic Neoplasms - immunology Protein synthesis Rats RIN-m5F cell line
Online-Zugang:	Volltext
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