Outcome of children with primary intramedullary spinal cord tumors
The influence of clinical and treatment factors on the outcome of children with primary intramedullary spinal cord tumors (PST) was evaluated by reviewing the records of 26 children diagnosed during the 15-year period 1970-1984. Five-year survival was 39%, but 5-year event-free survival (EFS) was on...
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| Veröffentlicht in: | Child's nervous system 1987-01, Vol.3 (2), p.89-92 |
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| container_title | Child's nervous system |
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| creator | HUNTLEY HARDISON, H PACKER, R. J RORKE, L. B SCHUT, L SUTTON, L. N BRUCE, D. A |
| description | The influence of clinical and treatment factors on the outcome of children with primary intramedullary spinal cord tumors (PST) was evaluated by reviewing the records of 26 children diagnosed during the 15-year period 1970-1984. Five-year survival was 39%, but 5-year event-free survival (EFS) was only 14%. Eighteen-month EFS was 53% (9/17) among children with low-grade astrocytoma. 100% (2/2) with ependymoma, and 0 of 7 with anaplastic astrocytoma or ganglioglioma. There was no significant difference in the 18-month EFS by location of tumor, duration of symptoms, or extent of surgical removal. Five of 9 children with locally recurrent PST had a second operation, and 4 were alive a median of 56 months later. PST disseminated to the leptomeninges or the III ventricle in 5 children: 2 at diagnosis, 2 as the first sign of disease relapse, and 1 after local recurrence. Given the poor outcome of our children, different methods of treatment for children with tumors in this location should be evaluated. |
| doi_str_mv | 10.1007/BF00271131 |
| format | Article |
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J ; RORKE, L. B ; SCHUT, L ; SUTTON, L. N ; BRUCE, D. A</creator><creatorcontrib>HUNTLEY HARDISON, H ; PACKER, R. J ; RORKE, L. B ; SCHUT, L ; SUTTON, L. N ; BRUCE, D. A</creatorcontrib><description>The influence of clinical and treatment factors on the outcome of children with primary intramedullary spinal cord tumors (PST) was evaluated by reviewing the records of 26 children diagnosed during the 15-year period 1970-1984. Five-year survival was 39%, but 5-year event-free survival (EFS) was only 14%. Eighteen-month EFS was 53% (9/17) among children with low-grade astrocytoma. 100% (2/2) with ependymoma, and 0 of 7 with anaplastic astrocytoma or ganglioglioma. There was no significant difference in the 18-month EFS by location of tumor, duration of symptoms, or extent of surgical removal. Five of 9 children with locally recurrent PST had a second operation, and 4 were alive a median of 56 months later. PST disseminated to the leptomeninges or the III ventricle in 5 children: 2 at diagnosis, 2 as the first sign of disease relapse, and 1 after local recurrence. Given the poor outcome of our children, different methods of treatment for children with tumors in this location should be evaluated.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/BF00271131</identifier><identifier>PMID: 3040249</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Astrocytoma - diagnosis ; Astrocytoma - mortality ; Astrocytoma - surgery ; Biological and medical sciences ; Child ; Child, Preschool ; Combined Modality Therapy ; Ependymoma - diagnosis ; Ependymoma - mortality ; Ependymoma - surgery ; Female ; Follow-Up Studies ; Glioblastoma - diagnosis ; Glioblastoma - mortality ; Glioblastoma - surgery ; Humans ; Infant ; Male ; Medical sciences ; Neoplasm Recurrence, Local ; Neuroblastoma - diagnosis ; Neuroblastoma - mortality ; Neuroblastoma - surgery ; Neurology ; Spinal Cord Neoplasms - diagnosis ; Spinal Cord Neoplasms - mortality ; Spinal Cord Neoplasms - surgery ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Child's nervous system, 1987-01, Vol.3 (2), p.89-92</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-9be3adbf675ac78b167b1c216942428b871b9fafa72657e36d00d1d786cf3ef43</citedby><cites>FETCH-LOGICAL-c311t-9be3adbf675ac78b167b1c216942428b871b9fafa72657e36d00d1d786cf3ef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8362428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3040249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUNTLEY HARDISON, H</creatorcontrib><creatorcontrib>PACKER, R. J</creatorcontrib><creatorcontrib>RORKE, L. B</creatorcontrib><creatorcontrib>SCHUT, L</creatorcontrib><creatorcontrib>SUTTON, L. N</creatorcontrib><creatorcontrib>BRUCE, D. A</creatorcontrib><title>Outcome of children with primary intramedullary spinal cord tumors</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>The influence of clinical and treatment factors on the outcome of children with primary intramedullary spinal cord tumors (PST) was evaluated by reviewing the records of 26 children diagnosed during the 15-year period 1970-1984. Five-year survival was 39%, but 5-year event-free survival (EFS) was only 14%. Eighteen-month EFS was 53% (9/17) among children with low-grade astrocytoma. 100% (2/2) with ependymoma, and 0 of 7 with anaplastic astrocytoma or ganglioglioma. There was no significant difference in the 18-month EFS by location of tumor, duration of symptoms, or extent of surgical removal. Five of 9 children with locally recurrent PST had a second operation, and 4 were alive a median of 56 months later. PST disseminated to the leptomeninges or the III ventricle in 5 children: 2 at diagnosis, 2 as the first sign of disease relapse, and 1 after local recurrence. Given the poor outcome of our children, different methods of treatment for children with tumors in this location should be evaluated.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Astrocytoma - diagnosis</subject><subject>Astrocytoma - mortality</subject><subject>Astrocytoma - surgery</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Ependymoma - diagnosis</subject><subject>Ependymoma - mortality</subject><subject>Ependymoma - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glioblastoma - diagnosis</subject><subject>Glioblastoma - mortality</subject><subject>Glioblastoma - surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neuroblastoma - diagnosis</subject><subject>Neuroblastoma - mortality</subject><subject>Neuroblastoma - surgery</subject><subject>Neurology</subject><subject>Spinal Cord Neoplasms - diagnosis</subject><subject>Spinal Cord Neoplasms - mortality</subject><subject>Spinal Cord Neoplasms - surgery</subject><subject>Tumors of the nervous system. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-9be3adbf675ac78b167b1c216942428b871b9fafa72657e36d00d1d786cf3ef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Astrocytoma - diagnosis</topic><topic>Astrocytoma - mortality</topic><topic>Astrocytoma - surgery</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Ependymoma - diagnosis</topic><topic>Ependymoma - mortality</topic><topic>Ependymoma - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glioblastoma - diagnosis</topic><topic>Glioblastoma - mortality</topic><topic>Glioblastoma - surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neuroblastoma - diagnosis</topic><topic>Neuroblastoma - mortality</topic><topic>Neuroblastoma - surgery</topic><topic>Neurology</topic><topic>Spinal Cord Neoplasms - diagnosis</topic><topic>Spinal Cord Neoplasms - mortality</topic><topic>Spinal Cord Neoplasms - surgery</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUNTLEY HARDISON, H</creatorcontrib><creatorcontrib>PACKER, R. J</creatorcontrib><creatorcontrib>RORKE, L. B</creatorcontrib><creatorcontrib>SCHUT, L</creatorcontrib><creatorcontrib>SUTTON, L. N</creatorcontrib><creatorcontrib>BRUCE, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUNTLEY HARDISON, H</au><au>PACKER, R. J</au><au>RORKE, L. B</au><au>SCHUT, L</au><au>SUTTON, L. N</au><au>BRUCE, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome of children with primary intramedullary spinal cord tumors</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>3</volume><issue>2</issue><spage>89</spage><epage>92</epage><pages>89-92</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>The influence of clinical and treatment factors on the outcome of children with primary intramedullary spinal cord tumors (PST) was evaluated by reviewing the records of 26 children diagnosed during the 15-year period 1970-1984. Five-year survival was 39%, but 5-year event-free survival (EFS) was only 14%. Eighteen-month EFS was 53% (9/17) among children with low-grade astrocytoma. 100% (2/2) with ependymoma, and 0 of 7 with anaplastic astrocytoma or ganglioglioma. There was no significant difference in the 18-month EFS by location of tumor, duration of symptoms, or extent of surgical removal. Five of 9 children with locally recurrent PST had a second operation, and 4 were alive a median of 56 months later. PST disseminated to the leptomeninges or the III ventricle in 5 children: 2 at diagnosis, 2 as the first sign of disease relapse, and 1 after local recurrence. Given the poor outcome of our children, different methods of treatment for children with tumors in this location should be evaluated.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3040249</pmid><doi>10.1007/BF00271131</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Astrocytoma - diagnosis Astrocytoma - mortality Astrocytoma - surgery Biological and medical sciences Child Child, Preschool Combined Modality Therapy Ependymoma - diagnosis Ependymoma - mortality Ependymoma - surgery Female Follow-Up Studies Glioblastoma - diagnosis Glioblastoma - mortality Glioblastoma - surgery Humans Infant Male Medical sciences Neoplasm Recurrence, Local Neuroblastoma - diagnosis Neuroblastoma - mortality Neuroblastoma - surgery Neurology Spinal Cord Neoplasms - diagnosis Spinal Cord Neoplasms - mortality Spinal Cord Neoplasms - surgery Tumors of the nervous system. Phacomatoses |
| title | Outcome of children with primary intramedullary spinal cord tumors |
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