Prevention and Treatment of Low-grade B-cell Primary Gastric Lymphoma by Anti-H. Pylori Therapy
Mucosa-associated lymphoid tissue (MALT) showing a follicular structure can develop in the gastric mucosa as a response to Helicobacter pylori infection. We emphasize the importance of anti-H. pylori antibiotic therapy in the elimination of acquired MALT. Of the 200 patients studied, acquired MALT w...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1995-09, Vol.21 (2), p.118-122 |
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| creator | Cammarota, Giovanni Tursi, Antonio Montalto, Massimo Papa, Alfredo Branca, Giovanna Vecchio, Fabio M Renzi, Cristina Verzí, Alfio Armuzzi, Alessandro Pretolani, Stefano Fedeli, Giuseppe Gasbarrini, Giovanni |
| description | Mucosa-associated lymphoid tissue (MALT) showing a follicular structure can develop in the gastric mucosa as a response to Helicobacter pylori infection. We emphasize the importance of anti-H. pylori antibiotic therapy in the elimination of acquired MALT. Of the 200 patients studied, acquired MALT was found in 70 of the 151 H. pylori-positive patients, whereas it was present in only five of the 49 H. pylori-negative patients. Thirty-eight H. pylori-positive and MALT-positive patients were treated with antibiotic therapy and reevaluated after 6 months21 patients were H. pylori negative/MALT negative, 12 were H. pylori positive/MALT positive, four were H. pylori negative/MALT positive, one was H. pylori positive/MALT negative. In the control group (n = 20), H. pylori and acquired MALT were still present at follow-up. One patient with histological and immunohisto-chemical evidence of low-grade B-cell gastric MALT lymphoma underwent antibiotic treatment and was reexamined after 8, 12, and 24 weekshistological examination of biopsy samples showed regression of the MALT lymphoma in tandem with the disappearance of H. pylori colonization. Our data confirm the correlation between H. pylori infection and acquired MALT, as documented by the ability of antibiotic therapy to induce the disappearance of acquired MALT and regression of MALT lymphoma. Considering the potential evolution of MALT into low-grade B-cell MALT lymphoma, H. pylori eradication should play a role in the prevention of this tumor. |
| doi_str_mv | 10.1097/00004836-199509000-00011 |
| format | Article |
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Pylori Therapy</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Cammarota, Giovanni ; Tursi, Antonio ; Montalto, Massimo ; Papa, Alfredo ; Branca, Giovanna ; Vecchio, Fabio M ; Renzi, Cristina ; Verzí, Alfio ; Armuzzi, Alessandro ; Pretolani, Stefano ; Fedeli, Giuseppe ; Gasbarrini, Giovanni</creator><creatorcontrib>Cammarota, Giovanni ; Tursi, Antonio ; Montalto, Massimo ; Papa, Alfredo ; Branca, Giovanna ; Vecchio, Fabio M ; Renzi, Cristina ; Verzí, Alfio ; Armuzzi, Alessandro ; Pretolani, Stefano ; Fedeli, Giuseppe ; Gasbarrini, Giovanni</creatorcontrib><description>Mucosa-associated lymphoid tissue (MALT) showing a follicular structure can develop in the gastric mucosa as a response to Helicobacter pylori infection. We emphasize the importance of anti-H. pylori antibiotic therapy in the elimination of acquired MALT. Of the 200 patients studied, acquired MALT was found in 70 of the 151 H. pylori-positive patients, whereas it was present in only five of the 49 H. pylori-negative patients. Thirty-eight H. pylori-positive and MALT-positive patients were treated with antibiotic therapy and reevaluated after 6 months21 patients were H. pylori negative/MALT negative, 12 were H. pylori positive/MALT positive, four were H. pylori negative/MALT positive, one was H. pylori positive/MALT negative. In the control group (n = 20), H. pylori and acquired MALT were still present at follow-up. One patient with histological and immunohisto-chemical evidence of low-grade B-cell gastric MALT lymphoma underwent antibiotic treatment and was reexamined after 8, 12, and 24 weekshistological examination of biopsy samples showed regression of the MALT lymphoma in tandem with the disappearance of H. pylori colonization. Our data confirm the correlation between H. pylori infection and acquired MALT, as documented by the ability of antibiotic therapy to induce the disappearance of acquired MALT and regression of MALT lymphoma. Considering the potential evolution of MALT into low-grade B-cell MALT lymphoma, H. pylori eradication should play a role in the prevention of this tumor.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-199509000-00011</identifier><identifier>PMID: 8583076</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Adult ; Aged ; Amoxicillin - therapeutic use ; Antitrichomonal Agents - therapeutic use ; Biological and medical sciences ; Drug Therapy, Combination ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; Lymphoma, B-Cell, Marginal Zone - drug therapy ; Lymphoma, B-Cell, Marginal Zone - microbiology ; Lymphoma, B-Cell, Marginal Zone - pathology ; Lymphoma, B-Cell, Marginal Zone - prevention & control ; Male ; Medical sciences ; Middle Aged ; Omeprazole - therapeutic use ; Penicillins - therapeutic use ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology ; Stomach Neoplasms - prevention & control ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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Pylori Therapy</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>Mucosa-associated lymphoid tissue (MALT) showing a follicular structure can develop in the gastric mucosa as a response to Helicobacter pylori infection. We emphasize the importance of anti-H. pylori antibiotic therapy in the elimination of acquired MALT. Of the 200 patients studied, acquired MALT was found in 70 of the 151 H. pylori-positive patients, whereas it was present in only five of the 49 H. pylori-negative patients. Thirty-eight H. pylori-positive and MALT-positive patients were treated with antibiotic therapy and reevaluated after 6 months21 patients were H. pylori negative/MALT negative, 12 were H. pylori positive/MALT positive, four were H. pylori negative/MALT positive, one was H. pylori positive/MALT negative. In the control group (n = 20), H. pylori and acquired MALT were still present at follow-up. One patient with histological and immunohisto-chemical evidence of low-grade B-cell gastric MALT lymphoma underwent antibiotic treatment and was reexamined after 8, 12, and 24 weekshistological examination of biopsy samples showed regression of the MALT lymphoma in tandem with the disappearance of H. pylori colonization. Our data confirm the correlation between H. pylori infection and acquired MALT, as documented by the ability of antibiotic therapy to induce the disappearance of acquired MALT and regression of MALT lymphoma. Considering the potential evolution of MALT into low-grade B-cell MALT lymphoma, H. pylori eradication should play a role in the prevention of this tumor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amoxicillin - therapeutic use</subject><subject>Antitrichomonal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. 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Anus</topic><topic>Tinidazole - therapeutic use</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cammarota, Giovanni</creatorcontrib><creatorcontrib>Tursi, Antonio</creatorcontrib><creatorcontrib>Montalto, Massimo</creatorcontrib><creatorcontrib>Papa, Alfredo</creatorcontrib><creatorcontrib>Branca, Giovanna</creatorcontrib><creatorcontrib>Vecchio, Fabio M</creatorcontrib><creatorcontrib>Renzi, Cristina</creatorcontrib><creatorcontrib>Verzí, Alfio</creatorcontrib><creatorcontrib>Armuzzi, Alessandro</creatorcontrib><creatorcontrib>Pretolani, Stefano</creatorcontrib><creatorcontrib>Fedeli, Giuseppe</creatorcontrib><creatorcontrib>Gasbarrini, Giovanni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cammarota, Giovanni</au><au>Tursi, Antonio</au><au>Montalto, Massimo</au><au>Papa, Alfredo</au><au>Branca, Giovanna</au><au>Vecchio, Fabio M</au><au>Renzi, Cristina</au><au>Verzí, Alfio</au><au>Armuzzi, Alessandro</au><au>Pretolani, Stefano</au><au>Fedeli, Giuseppe</au><au>Gasbarrini, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention and Treatment of Low-grade B-cell Primary Gastric Lymphoma by Anti-H. Pylori Therapy</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1995-09</date><risdate>1995</risdate><volume>21</volume><issue>2</issue><spage>118</spage><epage>122</epage><pages>118-122</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>Mucosa-associated lymphoid tissue (MALT) showing a follicular structure can develop in the gastric mucosa as a response to Helicobacter pylori infection. We emphasize the importance of anti-H. pylori antibiotic therapy in the elimination of acquired MALT. Of the 200 patients studied, acquired MALT was found in 70 of the 151 H. pylori-positive patients, whereas it was present in only five of the 49 H. pylori-negative patients. Thirty-eight H. pylori-positive and MALT-positive patients were treated with antibiotic therapy and reevaluated after 6 months21 patients were H. pylori negative/MALT negative, 12 were H. pylori positive/MALT positive, four were H. pylori negative/MALT positive, one was H. pylori positive/MALT negative. In the control group (n = 20), H. pylori and acquired MALT were still present at follow-up. One patient with histological and immunohisto-chemical evidence of low-grade B-cell gastric MALT lymphoma underwent antibiotic treatment and was reexamined after 8, 12, and 24 weekshistological examination of biopsy samples showed regression of the MALT lymphoma in tandem with the disappearance of H. pylori colonization. Our data confirm the correlation between H. pylori infection and acquired MALT, as documented by the ability of antibiotic therapy to induce the disappearance of acquired MALT and regression of MALT lymphoma. Considering the potential evolution of MALT into low-grade B-cell MALT lymphoma, H. pylori eradication should play a role in the prevention of this tumor.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8583076</pmid><doi>10.1097/00004836-199509000-00011</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of clinical gastroenterology, 1995-09, Vol.21 (2), p.118-122 |
| issn | 0192-0790 1539-2031 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Amoxicillin - therapeutic use Antitrichomonal Agents - therapeutic use Biological and medical sciences Drug Therapy, Combination Female Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter pylori Humans Lymphoma, B-Cell, Marginal Zone - drug therapy Lymphoma, B-Cell, Marginal Zone - microbiology Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, B-Cell, Marginal Zone - prevention & control Male Medical sciences Middle Aged Omeprazole - therapeutic use Penicillins - therapeutic use Stomach Neoplasms - drug therapy Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Stomach Neoplasms - prevention & control Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tinidazole - therapeutic use Tumors |
| title | Prevention and Treatment of Low-grade B-cell Primary Gastric Lymphoma by Anti-H. Pylori Therapy |
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