Decreased contractile responses to isoproterenol in isolated cardiac myocytes from ageing guinea-pigs

We have characterized the age-related changes of contractility and β-adrenoceptor function in isolated cardiac myocytes from guinea-pigs. We used either adult animals from 2 to 14 weeks of age, where body weight increases linearly with age, or senescent ones aged between 53–65 weeks. There was some...

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