The effect of LHRH analogs on pregnancy in the baboon
Thirty-three baboons were maintained throughout their peri-ovulatory period in group enclosures with fertile males. They received treatment on days 14–19 of presumed pregnancy with either twice daily injection of 50ug of an LHRH agonist or of 2 mg of an LHRH antagonist. Three pregnancies from 14 cyc...
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| Veröffentlicht in: | Contraception (Stoneham) 1987-04, Vol.35 (4), p.389-393 |
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| container_title | Contraception (Stoneham) |
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| creator | Eley, Robert M. |
| description | Thirty-three baboons were maintained throughout their peri-ovulatory period in group enclosures with fertile males. They received treatment on days 14–19 of presumed pregnancy with either twice daily injection of 50ug of an LHRH agonist or of 2 mg of an LHRH antagonist. Three pregnancies from 14 cycles were maintained in each of the treatment groups as compared to 5 of 14 in controls. Four abortions were noted but as 1 occurred in a control group the response could not be attributed to treatment. The agonist had no apparent effect on urinary progestins in non-pregnant animals but both analogs did cause a transient decline in pregnant animals. Results indicated that LHRH analogs are not suitable agents for early pregnancy termination under the present treatment regimen. |
| doi_str_mv | 10.1016/0010-7824(87)90075-8 |
| format | Article |
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Obstetrics</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>Medical sciences</subject><subject>Nafarelin</subject><subject>Papio</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>Pregnanediol - analogs & derivatives</subject><subject>Pregnanediol - urine</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKAzEQhoMotVbfQCEHET2sJs0mmb0IUtQKBUHqOWQ3s7qy3dRkK_TtTW3p0dN_-L8ZZj5Czjm75YyrO8Y4yzSM82vQNwVjWmZwQIYcdJExyeGQDPfIMTmJ8YslqJB6QAbjFFypIZHzT6RY11j11Nd0Nn2bUtvZ1n9E6ju6DPjR2a5a06ajfUJLW3rfnZKj2rYRz3Y5Iu9Pj_PJNJu9Pr9MHmZZJUD1WelUrbm1WhWyQgcKXOGEcwUKLax1gFaJXGgAJhGQS4Bc5Q5Rlk4qVYgRudruXQb_vcLYm0UTK2xb26FfRaO1knwsRQLzLVgFH2PA2ixDs7BhbTgzG1tmo8JsVBjQ5s-WgTR2sdu_Khfo9kM7Pam_3PU2VratQ1LRxD2mc1BcsITdbzFMLn4aDCZWDXbp5SYkscb55v87fgGIL4PA</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Eley, Robert M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870401</creationdate><title>The effect of LHRH analogs on pregnancy in the baboon</title><author>Eley, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-bd6f71aa7695ced868d9d3dd9e373aad8ea634378805e8e1588464dee5bd56693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>Medical sciences</topic><topic>Nafarelin</topic><topic>Papio</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>Pregnanediol - analogs & derivatives</topic><topic>Pregnanediol - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eley, Robert M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eley, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of LHRH analogs on pregnancy in the baboon</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>35</volume><issue>4</issue><spage>389</spage><epage>393</epage><pages>389-393</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>Thirty-three baboons were maintained throughout their peri-ovulatory period in group enclosures with fertile males. 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| fulltext | fulltext |
| identifier | ISSN: 0010-7824 |
| ispartof | Contraception (Stoneham), 1987-04, Vol.35 (4), p.389-393 |
| issn | 0010-7824 1879-0518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Birth control Female Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Gynecology. Andrology. Obstetrics Induced abortion. Therapeutic abortion Medical sciences Nafarelin Papio Pregnancy Pregnancy, Animal - drug effects Pregnanediol - analogs & derivatives Pregnanediol - urine |
| title | The effect of LHRH analogs on pregnancy in the baboon |
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