Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases

Signal transduction by T and B cell Ag receptors and certain receptors for Ig Fc regions (Fc gamma RI, hFc gamma RIIA, Fc gamma RIII, Fc alpha R, and Fc epsilon RI) involves a conserved sequence motif, termed an immunoreceptor tyrosine-based activation motif (ITAM) and found in multiple receptor cha...

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Veröffentlicht in:	The Journal of immunology (1950) 1995-11, Vol.155 (10), p.4596-4603
Hauptverfasser:	Johnson, SA, Pleiman, CM, Pao, L, Schneringer, J, Hippen, K, Cambier, JC
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Cells, Cultured Enzyme Activation Humans Lymphocytes - metabolism Molecular Sequence Data Peptides - chemical synthesis Peptides - chemistry Phosphorylation Protein-Tyrosine Kinases - metabolism Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - metabolism Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism Sequence Analysis Signal Transduction
Online-Zugang:	Volltext
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