The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase

Addition of cAMP to cells has been shown to inhibit phosphatidylinositol (PI) metabolism. cAMP has been reported to inhibit an enzyme in this pathway, PI kinase and it has been suggested that this inhibition is due to phosphorylation of PI kinase by the cAMP dependent protein kinase (PKA). In the pr...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-07, Vol.146 (2), p.561-567
Hauptverfasser:	O'Shea, John J., Suárez-Quian, Carlos A., Swank, Richard A., Klausner, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 4-Kinase Adenosine - analogs & derivatives Adenosine - pharmacology Animals cyclic AMP Cyclic AMP - pharmacology Liver - enzymology Mice Phosphotransferases - antagonists & inhibitors Protein Kinases - metabolism
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