Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP
Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent de...
Gespeichert in:
| Veröffentlicht in: | Bioscience reports 1987-01, Vol.7 (1), p.23-31 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 31 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | Bioscience reports |
| container_volume | 7 |
| creator | Estrela, J M Montoro, J B Viña, J R Viña, J |
| description | Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of other metabolic pathways by acini. |
| doi_str_mv | 10.1007/BF01122724 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77650151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77650151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-6b5151502bbf61d36aa7379990b9d1f141ba5102f327c784cefb7e7b7a8f1b993</originalsourceid><addsrcrecordid>eNpFkMtOwzAQRS0EglLYsEfyigVSwI8kbpaAWkCqBAtYR7YzboOcuPgh0a_gl0loBfJiJN8zd2YuQheU3FBCxO39glDKmGD5AZrQQvAsr3hxiCaE5nk2y0t-gk5D-CCEDEJ-jI55yUhJ6AR9P9oUZVy3rgfcQZTK2TZ0OPUNeBzXgNve2AS9BuwMXm8b7zbg3VfbQBi0X8RKPXi0_Qp3suuk3-KVlX0zNoyyl_EGz40BHcevlU3aBcAjAV_RSw3WJis9vnt7PUNHRtoA5_s6Re-L-dvDU7Z8eXx-uFtmms1YzEpV0OERppQpacNLKQUXVVURVTXU0JwqWVDCDGdCi1muwSgBQgk5M1RVFZ-iq53vxrvPBCHWXRvGRWQPLoVaiLIgw4gBvN6B2rsQPJh649vxxpqSeky__k9_gC_3rkl10Pyh-7j5DweCgNQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77650151</pqid></control><display><type>article</type><title>Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Estrela, J M ; Montoro, J B ; Viña, J R ; Viña, J</creator><creatorcontrib>Estrela, J M ; Montoro, J B ; Viña, J R ; Viña, J</creatorcontrib><description>Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of other metabolic pathways by acini.</description><identifier>ISSN: 0144-8463</identifier><identifier>EISSN: 1573-4935</identifier><identifier>DOI: 10.1007/BF01122724</identifier><identifier>PMID: 3620601</identifier><language>eng</language><publisher>England</publisher><subject>Adenosine Triphosphate - pharmacology ; Animals ; Female ; Glucose - metabolism ; Glucose - pharmacology ; Glutathione - metabolism ; In Vitro Techniques ; Lactation - metabolism ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - metabolism ; Peroxides - pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains ; tert-Butylhydroperoxide</subject><ispartof>Bioscience reports, 1987-01, Vol.7 (1), p.23-31</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-6b5151502bbf61d36aa7379990b9d1f141ba5102f327c784cefb7e7b7a8f1b993</citedby><cites>FETCH-LOGICAL-c282t-6b5151502bbf61d36aa7379990b9d1f141ba5102f327c784cefb7e7b7a8f1b993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3620601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Estrela, J M</creatorcontrib><creatorcontrib>Montoro, J B</creatorcontrib><creatorcontrib>Viña, J R</creatorcontrib><creatorcontrib>Viña, J</creatorcontrib><title>Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP</title><title>Bioscience reports</title><addtitle>Biosci Rep</addtitle><description>Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of other metabolic pathways by acini.</description><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glucose - pharmacology</subject><subject>Glutathione - metabolism</subject><subject>In Vitro Techniques</subject><subject>Lactation - metabolism</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Peroxides - pharmacology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>tert-Butylhydroperoxide</subject><issn>0144-8463</issn><issn>1573-4935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EglLYsEfyigVSwI8kbpaAWkCqBAtYR7YzboOcuPgh0a_gl0loBfJiJN8zd2YuQheU3FBCxO39glDKmGD5AZrQQvAsr3hxiCaE5nk2y0t-gk5D-CCEDEJ-jI55yUhJ6AR9P9oUZVy3rgfcQZTK2TZ0OPUNeBzXgNve2AS9BuwMXm8b7zbg3VfbQBi0X8RKPXi0_Qp3suuk3-KVlX0zNoyyl_EGz40BHcevlU3aBcAjAV_RSw3WJis9vnt7PUNHRtoA5_s6Re-L-dvDU7Z8eXx-uFtmms1YzEpV0OERppQpacNLKQUXVVURVTXU0JwqWVDCDGdCi1muwSgBQgk5M1RVFZ-iq53vxrvPBCHWXRvGRWQPLoVaiLIgw4gBvN6B2rsQPJh649vxxpqSeky__k9_gC_3rkl10Pyh-7j5DweCgNQ</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>Estrela, J M</creator><creator>Montoro, J B</creator><creator>Viña, J R</creator><creator>Viña, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198701</creationdate><title>Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP</title><author>Estrela, J M ; Montoro, J B ; Viña, J R ; Viña, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-6b5151502bbf61d36aa7379990b9d1f141ba5102f327c784cefb7e7b7a8f1b993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adenosine Triphosphate - pharmacology</topic><topic>Animals</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glucose - pharmacology</topic><topic>Glutathione - metabolism</topic><topic>In Vitro Techniques</topic><topic>Lactation - metabolism</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>Peroxides - pharmacology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>tert-Butylhydroperoxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Estrela, J M</creatorcontrib><creatorcontrib>Montoro, J B</creatorcontrib><creatorcontrib>Viña, J R</creatorcontrib><creatorcontrib>Viña, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Estrela, J M</au><au>Montoro, J B</au><au>Viña, J R</au><au>Viña, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP</atitle><jtitle>Bioscience reports</jtitle><addtitle>Biosci Rep</addtitle><date>1987-01</date><risdate>1987</risdate><volume>7</volume><issue>1</issue><spage>23</spage><epage>31</epage><pages>23-31</pages><issn>0144-8463</issn><eissn>1573-4935</eissn><abstract>Tert-butyl hydroperoxide decreases GSH and total free glutathione (GSH + 2GSSG) contents of acini from lactating mammary glands. The decrease in total free glutathione can be explained by an increase in mixed disulfide formation and by excretion of GSSG to the extracellular medium, and subsequent degradation catalyzed by gamma-glutamyl transpeptidase. Low concentrations of glucose prevented the changes in glutathione levels induced by the peroxide. In the presence of extracellular ATP, glucose did not prevent these changes. However, incubations with the peroxide, did not alter the rate of other metabolic pathways by acini.</abstract><cop>England</cop><pmid>3620601</pmid><doi>10.1007/BF01122724</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0144-8463 |
| ispartof | Bioscience reports, 1987-01, Vol.7 (1), p.23-31 |
| issn | 0144-8463 1573-4935 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77650151 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - pharmacology Animals Female Glucose - metabolism Glucose - pharmacology Glutathione - metabolism In Vitro Techniques Lactation - metabolism Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Peroxides - pharmacology Pregnancy Rats Rats, Inbred Strains tert-Butylhydroperoxide |
| title | Glutathione metabolism under the influence of hydroperoxides in the lactating mammary gland of the rat. Effect of glucose and extracellular ATP |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A37%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutathione%20metabolism%20under%20the%20influence%20of%20hydroperoxides%20in%20the%20lactating%20mammary%20gland%20of%20the%20rat.%20Effect%20of%20glucose%20and%20extracellular%20ATP&rft.jtitle=Bioscience%20reports&rft.au=Estrela,%20J%20M&rft.date=1987-01&rft.volume=7&rft.issue=1&rft.spage=23&rft.epage=31&rft.pages=23-31&rft.issn=0144-8463&rft.eissn=1573-4935&rft_id=info:doi/10.1007/BF01122724&rft_dat=%3Cproquest_cross%3E77650151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77650151&rft_id=info:pmid/3620601&rfr_iscdi=true |