Orphanin FQ: A Neuropeptide that Activates an Opioidlike G Protein-Coupled Receptor

A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP- binding protein (G protein)- coupled receptor (LC 132) that is similar in sequence to opioid receptors. This peptide, orphanin FQ, has a primary structure reminiscent of that of opi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-11, Vol.270 (5237), p.792-794
Hauptverfasser:	Reinscheid, Rainer K., Nothacker, Hans-Peter, Bourson, Anne, Ardati, Ali, Henningsen, Robert A., Bunzow, James R., Grandy, David K., Langen, Hanno, Monsma, Frederick J., Civelli, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclase Inhibitors Amino Acid Sequence Analgesics - pharmacology Animals Biochemistry and metabolism Biological and medical sciences Central nervous system CHO Cells Colforsin - pharmacology Cricetinae Dosage Fundamental and applied biological sciences. Psychology G proteins GTP-Binding Proteins - metabolism Hypothalamus - chemistry Injections, Intraventricular Injections, Spinal Ligands Mice Molecular Sequence Data Motor Activity - drug effects Neuropeptides Nociceptin Opioid peptides Opioid Peptides - chemistry Opioid Peptides - isolation & purification Opioid Peptides - metabolism Opioid Peptides - pharmacology Opioid receptors Opioids Orphans Pain Measurement Receptors Receptors, Neuropeptide - metabolism Receptors, Opioid - metabolism String theory Swine Transfection Vertebrates: nervous system and sense organs
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