Calcifying disorders of the skin

Calcium is vital to many biologic processes. In skin, it has a profound effect on keratinocyte proliferation, differentiation, and cell-cell adhesion. Serum calcium is tightly regulated by parathyroid hormone and 1,25(OH) 2D 3. Despite this careful regulation, calcification and ossification of cutan...

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Veröffentlicht in:Journal of the American Academy of Dermatology 1995-11, Vol.33 (5), p.693-706
Hauptverfasser: Walsh, John S, Fairley, Janet A
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container_title Journal of the American Academy of Dermatology
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creator Walsh, John S
Fairley, Janet A
description Calcium is vital to many biologic processes. In skin, it has a profound effect on keratinocyte proliferation, differentiation, and cell-cell adhesion. Serum calcium is tightly regulated by parathyroid hormone and 1,25(OH) 2D 3. Despite this careful regulation, calcification and ossification of cutaneous and subcutaneous tissues may occur. Cutaneous calcification may be divided into four major categories: dystrophic, metastatic, idiopathic, and iatrogenic. Dystrophic calcification occurs as a results of local tissue injury or abnormalities. Metastatic calcification results from abnormal calcium and/or phosphate metabolism. Virtually any process that calcifies may secondarily ossify. Primary ossification may rarely occur.
doi_str_mv 10.1016/0190-9622(95)91803-5
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Biological and medical sciences
Calcinosis - etiology
Calcinosis - pathology
Calcinosis - physiopathology
Calcium - physiology
Dermatology
Humans
Medical sciences
Skin Diseases - etiology
Skin Diseases - pathology
Skin Diseases - physiopathology
Skin involvement in other diseases. Miscellaneous. General aspects
title Calcifying disorders of the skin
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