The effects of polyoxyethylated cholesterol feeding on hepatic cholesterol synthesis and intestinal cholesterol absorption in rats

Adduction of ethylene glycol moieties to the 3-hydroxy position of cholesterol produces polyoxyethylated cholesterol (POEC), a water-soluble compound that suppresses cholesterol synthesis and esterification in cultured human fibroblasts. Feeding Sprague-Dawley rats a diet containing 2% (wt/wt) POEC...

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Veröffentlicht in:	Atherosclerosis 1987-04, Vol.64 (2), p.117-123
Hauptverfasser:	Amorosa, L.F., Stevenson, N.R., Wilson, A.C., Schwartz, M., Vitug, A., Khachadurian, A.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol - biosynthesis Cholesterol - metabolism Cholesterol absorption Hepatic cholesterol synthesis Intestinal Absorption - drug effects Liver - drug effects Liver - metabolism Male Medical sciences Polyethylene Glycols - pharmacology Polyoxyethylated cholesterol Rats Rats, Inbred Strains
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