GABA-dependent modulation of the Cl − ionophore by steroids in rat brain

Steroids inhibit the binding of [ 35S]t-butylbicyclophosphorothionate ([ 35S]TBPS) to the GABA A-benzodiazepine receptor (GBR) linked Cl − ionophore in a GABA dependent manner but not through the GABA A receptor. The most potent steroid evaluated is a naturally occuring metabolite of progesterone, 3...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1987-04, Vol.136 (3), p.419-423
Hauptverfasser:	Gee, Kelvin W., Chang, Wen-Chung, Brinton, Roberta E., McEwen, Bruce S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics Animals Anticonvulsants Biochemistry and metabolism Biological and medical sciences Brain Chemistry - drug effects Bridged Bicyclo Compounds - metabolism Bridged Bicyclo Compounds, Heterocyclic Central nervous system Chloride channels Chlorides - metabolism Cholesterol - pharmacology Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - physiology In Vitro Techniques Ionophores - metabolism Male Progesterone Rats Rats, Inbred Strains Steroids Steroids - pharmacology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!