Intracellular stability of the interfering activity of a defective interfering influenza virus in the absence of virus multiplication
Half-lives of the interfering activity of a human defective interfering (DI) influenza virus and of viral RNA in MDCK cells inoculated with noninfectious DI virus were 25 and 17 days, respectively, and of viral RNA in cells inoculated with noninfectious uv-irradiated standard virus was 21 days. In n...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1987-08, Vol.159 (2), p.259-264 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Cane, Christopher McLain, Lesley Dimmock, Nigel J. |
| description | Half-lives of the interfering activity of a human defective interfering (DI) influenza virus and of viral RNA in MDCK cells inoculated with noninfectious DI virus were 25 and 17 days, respectively, and of viral RNA in cells inoculated with noninfectious uv-irradiated standard virus was 21 days. In neither case was there evidence of virus replication (
de novo synthesis of viral proteins, haemagglutinin, or infectivity). The half-life in BHK cells was shorter, although still considerable, showing evidence of a host contribution to stability. Implications of the putative persistence of influenza virus genes
in vivo to the natural history of the virus are discussed. |
| doi_str_mv | 10.1016/0042-6822(87)90463-6 |
| format | Article |
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de novo synthesis of viral proteins, haemagglutinin, or infectivity). The half-life in BHK cells was shorter, although still considerable, showing evidence of a host contribution to stability. Implications of the putative persistence of influenza virus genes
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de novo synthesis of viral proteins, haemagglutinin, or infectivity). The half-life in BHK cells was shorter, although still considerable, showing evidence of a host contribution to stability. Implications of the putative persistence of influenza virus genes
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| fulltext | fulltext |
| identifier | ISSN: 0042-6822 |
| ispartof | Virology (New York, N.Y.), 1987-08, Vol.159 (2), p.259-264 |
| issn | 0042-6822 1096-0341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77647258 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Cell Line Cricetinae Defective Viruses - physiology Dogs Fibroblasts - analysis Fibroblasts - microbiology Fundamental and applied biological sciences. Psychology Half-Life Influenza A virus - physiology influenza virus Kidney Mesocricetus Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA, Viral - isolation & purification RNA, Viral - physiology Virology Virus Replication |
| title | Intracellular stability of the interfering activity of a defective interfering influenza virus in the absence of virus multiplication |
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