Tunica media changes in the spontaneously hypertensive rat (SHR)
The histological, ultrastructural, morphometrical and histochemical aspects of the arterial media were studied in young and aged SHR, and compared to normotensive Wistar Kyoto rats. The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes:...
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| Veröffentlicht in: | Atherosclerosis 1987-05, Vol.65 (1), p.125-137 |
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| container_title | Atherosclerosis |
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| creator | Hadjiisky, P. Peyri, N. Grosgogeat, Y. |
| description | The histological, ultrastructural, morphometrical and histochemical aspects of the arterial media were studied in young and aged SHR, and compared to normotensive Wistar Kyoto rats. The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes: (1) Early generalized hypertrophy of smooth muscle cells (smc); (2) connective matrix neogenesis and (3) smc proliferation, more evident in peripheral vasculature. The present paper discusses the following hypertensive tunica media changes in relation to the atherosclerotic process: the decrease in lipolytic esterase and cholinesterase activities; the activation of some lysosomal enzymes; the increase in collagen, glycosaminoglycan and elastin content; the increased media thickness; the modified smc behavior (migration, secretion, proliferation). These alterations might positively influence arterial susceptibility to atherosclerosis through (a) reduced smc lipolytic activity; (b) slowed transmural diffusion; (c) perturbed efflux and (d) aggravated media hypoxia. |
| doi_str_mv | 10.1016/0021-9150(87)90014-1 |
| format | Article |
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The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes: (1) Early generalized hypertrophy of smooth muscle cells (smc); (2) connective matrix neogenesis and (3) smc proliferation, more evident in peripheral vasculature. The present paper discusses the following hypertensive tunica media changes in relation to the atherosclerotic process: the decrease in lipolytic esterase and cholinesterase activities; the activation of some lysosomal enzymes; the increase in collagen, glycosaminoglycan and elastin content; the increased media thickness; the modified smc behavior (migration, secretion, proliferation). These alterations might positively influence arterial susceptibility to atherosclerosis through (a) reduced smc lipolytic activity; (b) slowed transmural diffusion; (c) perturbed efflux and (d) aggravated media hypoxia.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/0021-9150(87)90014-1</identifier><identifier>PMID: 3606728</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Aging - pathology ; Alkaline Phosphatase - metabolism ; Animals ; Aorta, Thoracic - cytology ; Aorta, Thoracic - enzymology ; Aorta, Thoracic - pathology ; Arteriosclerosis - etiology ; Atherogenesis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. 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The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes: (1) Early generalized hypertrophy of smooth muscle cells (smc); (2) connective matrix neogenesis and (3) smc proliferation, more evident in peripheral vasculature. The present paper discusses the following hypertensive tunica media changes in relation to the atherosclerotic process: the decrease in lipolytic esterase and cholinesterase activities; the activation of some lysosomal enzymes; the increase in collagen, glycosaminoglycan and elastin content; the increased media thickness; the modified smc behavior (migration, secretion, proliferation). These alterations might positively influence arterial susceptibility to atherosclerosis through (a) reduced smc lipolytic activity; (b) slowed transmural diffusion; (c) perturbed efflux and (d) aggravated media hypoxia.</description><subject>Aging - pathology</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Aorta, Thoracic - cytology</subject><subject>Aorta, Thoracic - enzymology</subject><subject>Aorta, Thoracic - pathology</subject><subject>Arteriosclerosis - etiology</subject><subject>Atherogenesis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cholinesterases - metabolism</subject><subject>Endothelium - pathology</subject><subject>Endothelium - ultrastructure</subject><subject>Histochemistry</subject><subject>Histocytochemistry</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Hypertensive arteriopathy</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Rats</subject><subject>Rats, Inbred SHR - physiology</subject><subject>Rats, Inbred Strains - physiology</subject><subject>SHR</subject><subject>Ultrastructure</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFLwzAUhYMoc07_gUIfRLaHam6TJs2LKEOdMBB0Poc0vXWRrp1JN9i_t3Njjz7dh_Odw-Uj5BLoLVAQd5QmECtI6TCTI0Up8BiOSB8yqWLgGT8m_QNySs5C-KaUcglZj_SYoEImWZ88zFa1syZaYOFMZOem_sIQuTpq5xiFZVO3psZmFapNNN8s0bdYB7fGyJs2Gn5M3kfn5KQ0VcCL_R2Qz-en2XgST99eXseP09jyNGljxkspCsqYKEyOTHC0KjdWpZjlRa6SIgHBVUozUCglSyG3pcoTlirIC55aNiA3u92lb35WGFq9cMFiVe3-01IKniilOpDvQOubEDyWeundwviNBqq34vTWit5a0ZnUf-I0dLWr_f4q72QcSntTXX69z02wpiq9qa0LB0ymIJgSHXa_w7BzsXbodbAOa9vp9WhbXTTu_z9-ARfRiCA</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Hadjiisky, P.</creator><creator>Peyri, N.</creator><creator>Grosgogeat, Y.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870501</creationdate><title>Tunica media changes in the spontaneously hypertensive rat (SHR)</title><author>Hadjiisky, P. ; Peyri, N. ; Grosgogeat, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-34f76d0336dabe364ec9bac95e8bdb92d2164950819e77351bcf9b23591bd45c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aging - pathology</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Aorta, Thoracic - cytology</topic><topic>Aorta, Thoracic - enzymology</topic><topic>Aorta, Thoracic - pathology</topic><topic>Arteriosclerosis - etiology</topic><topic>Atherogenesis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cholinesterases - metabolism</topic><topic>Endothelium - pathology</topic><topic>Endothelium - ultrastructure</topic><topic>Histochemistry</topic><topic>Histocytochemistry</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Hypertensive arteriopathy</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Rats</topic><topic>Rats, Inbred SHR - physiology</topic><topic>Rats, Inbred Strains - physiology</topic><topic>SHR</topic><topic>Ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hadjiisky, P.</creatorcontrib><creatorcontrib>Peyri, N.</creatorcontrib><creatorcontrib>Grosgogeat, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hadjiisky, P.</au><au>Peyri, N.</au><au>Grosgogeat, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tunica media changes in the spontaneously hypertensive rat (SHR)</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>65</volume><issue>1</issue><spage>125</spage><epage>137</epage><pages>125-137</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>The histological, ultrastructural, morphometrical and histochemical aspects of the arterial media were studied in young and aged SHR, and compared to normotensive Wistar Kyoto rats. The diffuse thickening was the most characteristic feature of the hypertensive media. It seems due to three processes: (1) Early generalized hypertrophy of smooth muscle cells (smc); (2) connective matrix neogenesis and (3) smc proliferation, more evident in peripheral vasculature. The present paper discusses the following hypertensive tunica media changes in relation to the atherosclerotic process: the decrease in lipolytic esterase and cholinesterase activities; the activation of some lysosomal enzymes; the increase in collagen, glycosaminoglycan and elastin content; the increased media thickness; the modified smc behavior (migration, secretion, proliferation). These alterations might positively influence arterial susceptibility to atherosclerosis through (a) reduced smc lipolytic activity; (b) slowed transmural diffusion; (c) perturbed efflux and (d) aggravated media hypoxia.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>3606728</pmid><doi>10.1016/0021-9150(87)90014-1</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging - pathology Alkaline Phosphatase - metabolism Animals Aorta, Thoracic - cytology Aorta, Thoracic - enzymology Aorta, Thoracic - pathology Arteriosclerosis - etiology Atherogenesis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholinesterases - metabolism Endothelium - pathology Endothelium - ultrastructure Histochemistry Histocytochemistry Hypertension - pathology Hypertension - physiopathology Hypertensive arteriopathy Medical sciences Microscopy, Electron Rats Rats, Inbred SHR - physiology Rats, Inbred Strains - physiology SHR Ultrastructure |
| title | Tunica media changes in the spontaneously hypertensive rat (SHR) |
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