Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects
Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion in two consecutive collection periods (5:00 PM-11:00 PM and 11:00 PM-8:00 AM) and whole blood serotonin (5-HT) and tryptophan (TRP) were measured in groups of unmedicated autistics (n = 16), medicated autistics (n = 20), and normal controls (n =...
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| Veröffentlicht in: | Biological psychiatry (1969) 1987-08, Vol.22 (8), p.933-940 |
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| container_title | Biological psychiatry (1969) |
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| creator | Minderaa, Ruud B. Anderson, George M. Volkmar, Fred R. Akkerhuis, Grard W. Cohen, Donald J. |
| description | Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion in two consecutive collection periods (5:00 PM-11:00 PM and 11:00 PM-8:00 AM) and whole blood serotonin (5-HT) and tryptophan (TRP) were measured in groups of unmedicated autistics (n = 16), medicated autistics (n = 20), and normal controls (n = 27). Whole blood 5-HT values were significantly higher in unmedicated autistics compared to normal controls. No significant differences were found in 5-HIAA excretion (microgram/mg creatinine, mean +/- SD) between unmedicated autistics (4.07 +/- 1.52) and normal controls (3.50 +/- 1.07), or between medicated (5.35 +/- 2.93) and drug-free autistic individuals. No correlations were found between 5-HT values and urinary 5-HIAA excretion. Urinary 5-HIAA (microgram/mg creatinine, mean +/- SD) was significantly greater in hyperserotonemic autistic subjects (4.88 +/- 0.87) compared to normal controls (3.50 +/- 1.07, total collection period; p = 0.002). The relevance of these findings to the possibility that increased gut production of 5-HT might cause the elevated whole blood 5-HT levels seen in autism is discussed. |
| doi_str_mv | 10.1016/0006-3223(87)90002-3 |
| format | Article |
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Whole blood 5-HT values were significantly higher in unmedicated autistics compared to normal controls. No significant differences were found in 5-HIAA excretion (microgram/mg creatinine, mean +/- SD) between unmedicated autistics (4.07 +/- 1.52) and normal controls (3.50 +/- 1.07), or between medicated (5.35 +/- 2.93) and drug-free autistic individuals. No correlations were found between 5-HT values and urinary 5-HIAA excretion. Urinary 5-HIAA (microgram/mg creatinine, mean +/- SD) was significantly greater in hyperserotonemic autistic subjects (4.88 +/- 0.87) compared to normal controls (3.50 +/- 1.07, total collection period; p = 0.002). The relevance of these findings to the possibility that increased gut production of 5-HT might cause the elevated whole blood 5-HT levels seen in autism is discussed.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(87)90002-3</identifier><identifier>PMID: 2440483</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Autistic Disorder - diagnosis ; Autistic Disorder - metabolism ; Biological and medical sciences ; Female ; Humans ; Hydroxyindoleacetic Acid - urine ; Male ; Medical sciences ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Whole blood 5-HT values were significantly higher in unmedicated autistics compared to normal controls. No significant differences were found in 5-HIAA excretion (microgram/mg creatinine, mean +/- SD) between unmedicated autistics (4.07 +/- 1.52) and normal controls (3.50 +/- 1.07), or between medicated (5.35 +/- 2.93) and drug-free autistic individuals. No correlations were found between 5-HT values and urinary 5-HIAA excretion. Urinary 5-HIAA (microgram/mg creatinine, mean +/- SD) was significantly greater in hyperserotonemic autistic subjects (4.88 +/- 0.87) compared to normal controls (3.50 +/- 1.07, total collection period; p = 0.002). The relevance of these findings to the possibility that increased gut production of 5-HT might cause the elevated whole blood 5-HT levels seen in autism is discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autistic Disorder - diagnosis</subject><subject>Autistic Disorder - metabolism</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Serotonin - blood</subject><subject>Techniques and methods</subject><subject>Tryptophan - blood</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVoSN20_yCFPZTSHLbR50p7CZSQtIFAL8lZyKMxVrqWXGk3jf995A987EnMvM8Mo4eQC0a_M8q6K0pp1wrOxTejL_ta8VackBkzWrRcUv6OzI7Ie_KhlOdaas7ZGTnjUlJpxIz8ecohurxpVLvc-JxeNyH6NKADHAM0DoJvXPTNv2VtNvMhJd8UzGlMMcRdMubNekzrpYvNtjONoewmaxRTXrmhKdP8GWEsH8npwg0FPx3ec_J0d_t486t9-P3z_ubHQwvSsLEF2gsqOwRNjegVBQUa5p3qUXVCi54Zzj3IzjPqkHrvhESDC6WEr__TXpyTr_u965z-TlhGuwoFcBhcxDQVq3UnmRJ9BeUehJxKybiw6xxW1YZl1G4d261AuxVojbY7x1bUsc-H_dN8hf44dJBa8y-H3BVwwyK7CKEcMS2VEZxV7HqPYXXxEjDbAgEjoA-56rI-hf_f8QZ-YZhv</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Minderaa, Ruud B.</creator><creator>Anderson, George M.</creator><creator>Volkmar, Fred R.</creator><creator>Akkerhuis, Grard W.</creator><creator>Cohen, Donald J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870801</creationdate><title>Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects</title><author>Minderaa, Ruud B. ; Anderson, George M. ; Volkmar, Fred R. ; Akkerhuis, Grard W. ; Cohen, Donald J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-c093046ec7083950c5c7cb659e5637391822dc46d10ae0dda34e8ef553d0077d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autistic Disorder - diagnosis</topic><topic>Autistic Disorder - metabolism</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Serotonin - blood</topic><topic>Techniques and methods</topic><topic>Tryptophan - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minderaa, Ruud B.</creatorcontrib><creatorcontrib>Anderson, George M.</creatorcontrib><creatorcontrib>Volkmar, Fred R.</creatorcontrib><creatorcontrib>Akkerhuis, Grard W.</creatorcontrib><creatorcontrib>Cohen, Donald J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minderaa, Ruud B.</au><au>Anderson, George M.</au><au>Volkmar, Fred R.</au><au>Akkerhuis, Grard W.</au><au>Cohen, Donald J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>22</volume><issue>8</issue><spage>933</spage><epage>940</epage><pages>933-940</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion in two consecutive collection periods (5:00 PM-11:00 PM and 11:00 PM-8:00 AM) and whole blood serotonin (5-HT) and tryptophan (TRP) were measured in groups of unmedicated autistics (n = 16), medicated autistics (n = 20), and normal controls (n = 27). Whole blood 5-HT values were significantly higher in unmedicated autistics compared to normal controls. No significant differences were found in 5-HIAA excretion (microgram/mg creatinine, mean +/- SD) between unmedicated autistics (4.07 +/- 1.52) and normal controls (3.50 +/- 1.07), or between medicated (5.35 +/- 2.93) and drug-free autistic individuals. No correlations were found between 5-HT values and urinary 5-HIAA excretion. Urinary 5-HIAA (microgram/mg creatinine, mean +/- SD) was significantly greater in hyperserotonemic autistic subjects (4.88 +/- 0.87) compared to normal controls (3.50 +/- 1.07, total collection period; p = 0.002). The relevance of these findings to the possibility that increased gut production of 5-HT might cause the elevated whole blood 5-HT levels seen in autism is discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2440483</pmid><doi>10.1016/0006-3223(87)90002-3</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Autistic Disorder - diagnosis Autistic Disorder - metabolism Biological and medical sciences Female Humans Hydroxyindoleacetic Acid - urine Male Medical sciences Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin - blood Techniques and methods Tryptophan - blood |
| title | Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects |
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