Improved recovery from a traumatic-hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor
Cats, injured by a mechanical plus hypoxic model of traumatic brain injury, were treated by intracisternal injection of a modified loop diuretic (L-644,711). This drug inhibits the chloride/bicarbonate anion exchange transport system. The treatment resulted in a significant decrease in mortality fro...
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| Veröffentlicht in: | Central nervous system trauma 1987, Vol.4 (1), p.3-14 |
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| container_title | Central nervous system trauma |
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| creator | KIMELBERG, H. K CRAGOE, E. J. JR NELSON, L. R POPP, A. J SZAROWSKI, D ROSE, J. W WOLTERSDORF, O. W. JR PIETRUSZKIEWICZ, A. M |
| description | Cats, injured by a mechanical plus hypoxic model of traumatic brain injury, were treated by intracisternal injection of a modified loop diuretic (L-644,711). This drug inhibits the chloride/bicarbonate anion exchange transport system. The treatment resulted in a significant decrease in mortality from 61 to 21%, and an improvement in both neurological status and EEG activity of the surviving animals. The dose of drug given intracisternally was at least 175 times less than the dosage we previously found was needed to achieve a comparable effect when the drug was given intravenously. The present results suggest that certain types of head injury can be treated by drugs which affect cellular anion transport processes in the brain. |
| doi_str_mv | 10.1089/cns.1987.4.3 |
| format | Article |
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K ; CRAGOE, E. J. JR ; NELSON, L. R ; POPP, A. J ; SZAROWSKI, D ; ROSE, J. W ; WOLTERSDORF, O. W. JR ; PIETRUSZKIEWICZ, A. M</creator><creatorcontrib>KIMELBERG, H. K ; CRAGOE, E. J. JR ; NELSON, L. R ; POPP, A. J ; SZAROWSKI, D ; ROSE, J. W ; WOLTERSDORF, O. W. JR ; PIETRUSZKIEWICZ, A. M</creatorcontrib><description>Cats, injured by a mechanical plus hypoxic model of traumatic brain injury, were treated by intracisternal injection of a modified loop diuretic (L-644,711). This drug inhibits the chloride/bicarbonate anion exchange transport system. The treatment resulted in a significant decrease in mortality from 61 to 21%, and an improvement in both neurological status and EEG activity of the surviving animals. The dose of drug given intracisternally was at least 175 times less than the dosage we previously found was needed to achieve a comparable effect when the drug was given intravenously. The present results suggest that certain types of head injury can be treated by drugs which affect cellular anion transport processes in the brain.</description><identifier>ISSN: 0737-5999</identifier><identifier>EISSN: 0737-5999</identifier><identifier>DOI: 10.1089/cns.1987.4.3</identifier><identifier>PMID: 3607899</identifier><language>eng</language><publisher>New York, NY: Liebert</publisher><subject>Animals ; Biological and medical sciences ; Brain Diseases - drug therapy ; Brain Diseases - mortality ; Brain Diseases - physiopathology ; Brain Injuries - drug therapy ; Brain Injuries - mortality ; Brain Injuries - physiopathology ; Cats ; Cisterna Magna ; Electroencephalography ; Fluorenes - administration & dosage ; Fluorenes - therapeutic use ; Hypoxia - drug therapy ; Hypoxia - mortality ; Hypoxia - physiopathology ; Injections ; Medical sciences ; Miscellaneous ; Nervous System - physiopathology ; Neuropharmacology ; Pharmacology. Drug treatments</subject><ispartof>Central nervous system trauma, 1987, Vol.4 (1), p.3-14</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c230t-7588de0c12157cef42388510a3fa9939fe7c3705123b9b1ad79537bb0b858aab3</citedby><cites>FETCH-LOGICAL-c230t-7588de0c12157cef42388510a3fa9939fe7c3705123b9b1ad79537bb0b858aab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7521997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3607899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMELBERG, H. K</creatorcontrib><creatorcontrib>CRAGOE, E. J. JR</creatorcontrib><creatorcontrib>NELSON, L. R</creatorcontrib><creatorcontrib>POPP, A. J</creatorcontrib><creatorcontrib>SZAROWSKI, D</creatorcontrib><creatorcontrib>ROSE, J. W</creatorcontrib><creatorcontrib>WOLTERSDORF, O. W. JR</creatorcontrib><creatorcontrib>PIETRUSZKIEWICZ, A. M</creatorcontrib><title>Improved recovery from a traumatic-hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor</title><title>Central nervous system trauma</title><addtitle>Cent Nerv Syst Trauma</addtitle><description>Cats, injured by a mechanical plus hypoxic model of traumatic brain injury, were treated by intracisternal injection of a modified loop diuretic (L-644,711). This drug inhibits the chloride/bicarbonate anion exchange transport system. The treatment resulted in a significant decrease in mortality from 61 to 21%, and an improvement in both neurological status and EEG activity of the surviving animals. The dose of drug given intracisternally was at least 175 times less than the dosage we previously found was needed to achieve a comparable effect when the drug was given intravenously. The present results suggest that certain types of head injury can be treated by drugs which affect cellular anion transport processes in the brain.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - drug therapy</subject><subject>Brain Diseases - mortality</subject><subject>Brain Diseases - physiopathology</subject><subject>Brain Injuries - drug therapy</subject><subject>Brain Injuries - mortality</subject><subject>Brain Injuries - physiopathology</subject><subject>Cats</subject><subject>Cisterna Magna</subject><subject>Electroencephalography</subject><subject>Fluorenes - administration & dosage</subject><subject>Fluorenes - therapeutic use</subject><subject>Hypoxia - drug therapy</subject><subject>Hypoxia - mortality</subject><subject>Hypoxia - physiopathology</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Nervous System - physiopathology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMELBERG, H. K</creatorcontrib><creatorcontrib>CRAGOE, E. J. JR</creatorcontrib><creatorcontrib>NELSON, L. R</creatorcontrib><creatorcontrib>POPP, A. J</creatorcontrib><creatorcontrib>SZAROWSKI, D</creatorcontrib><creatorcontrib>ROSE, J. W</creatorcontrib><creatorcontrib>WOLTERSDORF, O. W. JR</creatorcontrib><creatorcontrib>PIETRUSZKIEWICZ, A. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Central nervous system trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMELBERG, H. K</au><au>CRAGOE, E. J. 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The treatment resulted in a significant decrease in mortality from 61 to 21%, and an improvement in both neurological status and EEG activity of the surviving animals. The dose of drug given intracisternally was at least 175 times less than the dosage we previously found was needed to achieve a comparable effect when the drug was given intravenously. The present results suggest that certain types of head injury can be treated by drugs which affect cellular anion transport processes in the brain.</abstract><cop>New York, NY</cop><pub>Liebert</pub><pmid>3607899</pmid><doi>10.1089/cns.1987.4.3</doi><tpages>12</tpages></addata></record> |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Animals Biological and medical sciences Brain Diseases - drug therapy Brain Diseases - mortality Brain Diseases - physiopathology Brain Injuries - drug therapy Brain Injuries - mortality Brain Injuries - physiopathology Cats Cisterna Magna Electroencephalography Fluorenes - administration & dosage Fluorenes - therapeutic use Hypoxia - drug therapy Hypoxia - mortality Hypoxia - physiopathology Injections Medical sciences Miscellaneous Nervous System - physiopathology Neuropharmacology Pharmacology. Drug treatments |
| title | Improved recovery from a traumatic-hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor |
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