Demonstration of specific E-type prostaglandin receptors using enriched preparations of canine parietal cells and [ 3H] misoprostol free acid

High-affinity, E-type prostaglandin binding sites in enriched canine parietal cell preparations were identified with [ 3H] misoprostol free acid, a prostaglandin E 1 analogue. Saturable, reversible, and highly stereospecific binding was identified, with approximately 8,000 binding sites per cell. Pr...

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Veröffentlicht in:	The American journal of medicine 1987-07, Vol.83 (1), p.9-14
Hauptverfasser:	Tsai, Bie S., Kessler, Linda K., Schoenhard, Grant, Collins, Paul W., Bauer, Raymond F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - analogs & derivatives Alprostadil - metabolism Alprostadil - pharmacology Animals Anti-Ulcer Agents - metabolism Dogs Misoprostol Parietal Cells, Gastric - analysis Prostaglandins E - pharmacology Receptors, Prostaglandin - analysis Receptors, Prostaglandin - drug effects Receptors, Prostaglandin E Tritium
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