Melanoma Growth Stimulatory Activity Signaling through the Class II Interleukin-8 Receptor Enhances the Tyrosine Phosphorylation of Crk-Associated Substrate, p130, and a 70-Kilodalton Protein

Binding of the CXC chemokine, melanoma growth stimulatory activity (MGSA), to the class II IL-8 receptor on cells which overexpress this G-protein coupled receptor results in enhanced phosphorylation on serine residues. In experiments described herein, it is demonstrated that MGSA also enhances the...

Ausführliche Beschreibung